it is hydrolyzed by esterases in the liver, intestine, and cytoplasm into the active metabolite sn-38, which binds to and inhibits the function of topoisomerase i. topoisomerase i unwinds dna by making transient single strand breaks that relieves the torsion of supercoiled dna.
Parent Term
Biochemical pathway
Parent Definition
A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Metabolites Mapped to 'Irinotecan Metabolism Pathway'