it is extensively metabolized in the liver by the cytochrome p450 enzymes cyp2c8 and cyp2c9 to para-hydroxy rosiglitazon, ortho-hydroxy rosiglitazone and n-desmethyl rosiglitazone. n-desmethyl rosiglitazone is the major metabolite and is further metabolized to n-desmethyl-p-hydroxyrosiglitazone, n-desmethyl glucuronide rosiglitazone and n-desmethyl-o-hydroxy rosiglitazone.
Parent Term
Biochemical pathway
Parent Definition
A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Metabolites Mapped to 'Rosiglitazone Metabolism Pathway'