Metabolite: HMDB0000223 (Oxalacetic acid)
Term: The oncogenic action of 2-hydroxyglutarate
Definition: this compound is derived from the tca cycle. the compound 2-hydroxyglutarate is sufficiently similar in structure to 2-oxogluratate (2og) to inhibit a range of 2og-dependent dioxygenases,including histone lysine demethylases (kdms) and the ten-eleven translocation (tet) family of 5-methylcytosine (5mc) hydroxylases.
Parent Term: Biochemical pathway
Parent Definition: A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
Other Metabolites Mapped to 'The oncogenic action of 2-hydroxyglutarate'