Showing metabocard for Cytidine monophosphate (HMDB0000095)

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

Gene Name:

NT5E

Uniprot ID:

P21589

Molecular weight:

57948.125

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.

Gene Name:

CMPK1

Uniprot ID:

P30085

Molecular weight:

20180.12

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Gene Name:

NT5C1B

Uniprot ID:

Q96P26

Molecular weight:

68803.055

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

Gene Name:

NT5C1A

Uniprot ID:

Q9BXI3

Molecular weight:

41020.145

Reactions

General function:

Involved in metal ion binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Gene Name:

NT5C

Uniprot ID:

Q8TCD5

Molecular weight:

Not Available

Reactions

General function:

Involved in phosphatase activity

Specific function:

Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.

Gene Name:

NT5M

Uniprot ID:

Q9NPB1

Molecular weight:

Not Available

Reactions

General function:

Involved in hydrolase activity

Specific function:

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Gene Name:

ENTPD1

Uniprot ID:

P49961

Molecular weight:

58706.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

Gene Name:

CANT1

Uniprot ID:

Q8WVQ1

Molecular weight:

44839.24

General function:

Involved in hydrolase activity

Specific function:

Has a threefold preference for the hydrolysis of ATP over ADP.

Gene Name:

ENTPD3

Uniprot ID:

O75355

Molecular weight:

59104.76

Reactions

General function:

Involved in ATP binding

Specific function:

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Gene Name:

UCK1

Uniprot ID:

Q9HA47

Molecular weight:

22760.43

Reactions