Showing metabocard for Guanine (HMDB0000132)

General function:

Involved in adenine phosphoribosyltransferase activity

Specific function:

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.

Gene Name:

APRT

Uniprot ID:

P07741

Molecular weight:

19607.535

Reactions

General function:

Involved in hypoxanthine phosphoribosyltransferase activity

Specific function:

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

Gene Name:

HPRT1

Uniprot ID:

P00492

Molecular weight:

24579.155

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity).

Gene Name:

GDA

Uniprot ID:

Q9Y2T3

Molecular weight:

52836.65

Reactions

General function:

Involved in queuine tRNA-ribosyltransferase activity

Specific function:

Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).

Gene Name:

QTRT1

Uniprot ID:

Q9BXR0

Molecular weight:

44047.3

Reactions

General function:

Involved in GTP cyclohydrolase I activity

Specific function:

Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.

Gene Name:

GCH1

Uniprot ID:

P30793

Molecular weight:

27902.855

References

1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

General function:

Involved in signal transducer activity

Specific function:

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase:it activates the cyclase in response to beta-adrenergic stimuli

Gene Name:

GNAS

Uniprot ID:

P63092

Molecular weight:

45664.2

General function:

Involved in signal transducer activity

Specific function:

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems

Gene Name:

GNAQ

Uniprot ID:

P50148

Molecular weight:

42141.7

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Gene Name:

PNP

Uniprot ID:

P00491

Molecular weight:

32117.69

Reactions

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]

General function:

Involved in queuine tRNA-ribosyltransferase activity

Specific function:

Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).

Gene Name:

QTRTD1

Uniprot ID:

Q9H974

Molecular weight:

48203.07

Reactions

General function:

Involved in signal transducer activity

Specific function:

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase:they inhibit the cyclase in response to beta-adrenergic stimuli

Gene Name:

GNAI1

Uniprot ID:

P63096

Molecular weight:

40360.7