Showing metabocard for Thyroxine (HMDB0000248)

General function:

Involved in calcium ion binding

Specific function:

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Gene Name:

TPO

Uniprot ID:

P07202

Molecular weight:

102961.63

Reactions

General function:

Involved in thyroxine 5'-deiodinase activity

Specific function:

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.

Gene Name:

DIO1

Uniprot ID:

P49895

Molecular weight:

28924.21

Reactions

General function:

Involved in thyroxine 5'-deiodinase activity

Specific function:

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Gene Name:

DIO2

Uniprot ID:

Q92813

Molecular weight:

30551.48

Reactions

General function:

Involved in hormone activity

Specific function:

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain

Gene Name:

TTR

Uniprot ID:

P02766

Molecular weight:

15886.9

General function:

Involved in serine-type endopeptidase inhibitor activity

Specific function:

Major thyroid hormone transport protein in serum

Gene Name:

SERPINA7

Uniprot ID:

P05543

Molecular weight:

46324.1

General function:

Involved in catalytic activity

Specific function:

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier

Gene Name:

SLC3A2

Uniprot ID:

P08195

Molecular weight:

67993.3

General function:

Involved in thyroxine 5'-deiodinase activity

Specific function:

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

Gene Name:

DIO3

Uniprot ID:

P55073

Molecular weight:

33947.175

Reactions

General function:

Not Available

Specific function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).

Gene Name:

SULT6B1

Uniprot ID:

Q6IMI4

Molecular weight:

Not Available

Reactions