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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (4) Show 4 proteins XML

enzymes (4) Show 4 proteins

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2005-11-16 15:48:42 UTC

Update Date

2023-02-21 17:14:40 UTC

HMDB ID

HMDB0000257

Secondary Accession Numbers

HMDB00257

Metabolite Identification

Common Name

Thiosulfate

Description

Thiosulfate occurs naturally in hot springs and geysers, and is produced by certain biochemical processes. In the body, thiosulfate converts small amounts of cyanide ion into harmless products and plays a role in the biosynthesis of cysteine, a sulfur-containing amino acid that locks proteins into their correct three-dimensional shapes. Thiosulfate is not found in large quantities in nature. Solutions of thiosulfate break down into sulfur, sulfites, and sulfates when exposed to acids, light, metal ions, and bacteria. Thiosulfate is sometimes used as an antidote for cyanide poisoning. It reacts with cyanide to produce sulfite and thiocyanate ions: CN- + S2O32- SCN- + SO32- This reaction is catalyzed by an enzyme produced by cell mitochondria to neutralize small quantities of ingested cyanide (which occurs naturally in cassava root, lima beans, and almonds!). Thiosulfate is an intermediate in several biochemical pathways, including the synthesis of L-cysteine. Thiosulfate is manufactured by some cells by oxidation of elemental sulfur and by degradation of L-cysteine. Use: Photography (fixing agent to dissolve unchanged silver salts from exposed negatives), chrome tanning, removing chlorine in bleaching and papermaking, extraction of silver from its ores, dechlorination of water, mordant, reagent, bleaching, reducing agent in chrome dyeing, sequestrant in salt (up to 0.1%), antidote for cyanide poisoning. (Hawley's Condensed Chemical Dictionary) Source/Synthesis: Synthesis by dehydration of the pentahydrate at 105 degree. Alternatively formed by reaction of S2Cl2 with Na2O2 or by reduction of Na2S2O4 with sodium amalgam Use/Importance: Commercially available Biological Use/Importance: Cyanide antidote often administered with other antidotes, antifungal agent (ChemNetBase) Sodium thiosulfate is a common analytical reagent used in iodometric titration to analyze chlorine, bromine, and sulfide. Other uses are in bleaching paper pulp, bleaching straw, ivory, and bones, for removing chlorine from solutions, silver extraction from its ores, a mordant in dyeing and printing textiles, and as an antidote to cyanide poisoning. Another major application is in photography, where it is used as a fixer to dissolve unchanged silver salts from exposed negatives. (Handbook of Inorganic Chemicals).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
[SO2(OH)(SH)]	ChEBI
H2S2O3	ChEBI
Thiosulfuric acid	ChEBI
Thiosulphate	Generator
Thiosulphuric acid	Generator
Hydroxidodioxidosulfidosulfuric acid	HMDB
Hydroxidodioxidosulphidosulphate	HMDB
Hydroxidodioxidosulphidosulphuric acid	HMDB
Thiosulfate	Generator

Chemical Formula

H₂O₃S₂

Average Molecular Weight

114.144

Monoisotopic Molecular Weight

113.94453531

IUPAC Name

sulfanesulfonic acid

Traditional Name

sulfurothioic S-acid

CAS Registry Number

14383-50-7

SMILES

OS(S)(=O)=O

InChI Identifier

InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)

InChI Key

DHCDFWKWKRSZHF-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as non-metal thiosulfates. These are inorganic non-metallic compounds containing a thiosulfate as its largest oxoanion.

Kingdom

Inorganic compounds

Super Class

Homogeneous non-metal compounds

Class

Non-metal oxoanionic compounds

Sub Class

Non-metal thiosulfates

Direct Parent

Non-metal thiosulfates

Alternative Parents

Substituents

Non-metal thiosulfate
Inorganic oxide
Inorganic sulfide

Molecular Framework

Not Available

External Descriptors

thiosulfuric acid (CHEBI:29279 )

Ontology

Physiological effect

Health effect

Poisoning

Hydrogen sulfide poisoning (HMDB: HMDB0060293)

Disposition

Biological location

Cellular substructure

Cytoplasm (HMDB: HMDB0060293)
Extracellular (HMDB: HMDB0060293)

Organelle

Mitochondrion (HMDB: HMDB0060293)

Non-excretory biofluid

Biofluid or Excreta

Blood (HMDB: HMDB0060293)
Bile (HMDB: HMDB0060293)

Excreta

Biofluid or Excreta

Urine (HMDB: HMDB0060293)

Tissue

Epithelium

Epidermis (HMDB: HMDB0060293)

Source

Endogenous

Endogenous (HMDB: HMDB0060293)

Wild boar (FooDB: FOOD00307)
Domestic pig (FooDB: FOOD00536)

Poultry

Chicken (FooDB: FOOD00329)
Mallard duck (FooDB: FOOD00353)
Emu (FooDB: FOOD00360)
Greylag goose (FooDB: FOOD00368)
Guinea hen (FooDB: FOOD00373)
Ostrich (FooDB: FOOD00422)
Velvet duck (FooDB: FOOD00427)
Pheasant (FooDB: FOOD00430)
Squab (FooDB: FOOD00481)
Turkey (FooDB: FOOD00494)
Quail (FooDB: FOOD00541)
Anatidae (FooDB: FOOD00576)
Rock ptarmigan (FooDB: FOOD00597)
Columbidae (Dove, Pigeon) (FooDB: FOOD00610)

Venison

Mule deer (FooDB: FOOD00348)
Elk (FooDB: FOOD00359)
Deer (FooDB: FOOD00524)

Equine

Horse (FooDB: FOOD00378)

Lagomorph

Ovis

Sheep (Mutton, Lamb) (FooDB: FOOD00473)

Caprae

Domestic goat (FooDB: FOOD00529)

Not Available

Signaling molecule (HMDB: HMDB0060293)

Osmolyte (HMDB: HMDB0060293)

Industrial application

Pharmaceutical industry

Pharmaceutical (HMDB: HMDB0060293)

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	48 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	861 mg/mL	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
logP	-0.096	ChemAxon
pKa (Strongest Acidic)	-2.3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	54.37 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	17.76 m³·mol⁻¹	ChemAxon
Polarizability	8.29 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	119.643	31661259
DarkChem	[M+H]+	119.643	31661259
DarkChem	[M-H]-	110.909	31661259
DarkChem	[M-H]-	110.909	31661259
AllCCS	[M+H]+	129.385	32859911
AllCCS	[M-H]-	138.824	32859911
DeepCCS	[M+H]+	129.121	30932474
DeepCCS	[M-H]-	126.324	30932474
DeepCCS	[M-2H]-	162.793	30932474
DeepCCS	[M+Na]+	137.259	30932474
AllCCS	[M+H]+	129.4	32859911
AllCCS	[M+H-H2O]+	125.3	32859911
AllCCS	[M+NH4]+	133.2	32859911
AllCCS	[M+Na]+	134.3	32859911
AllCCS	[M-H]-	138.8	32859911
AllCCS	[M+Na-2H]-	144.5	32859911
AllCCS	[M+HCOO]-	150.7	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Thiosulfate	OS(S)(=O)=O	1703.9	Standard polar	33892256
Thiosulfate	OS(S)(=O)=O	747.5	Standard non polar	33892256
Thiosulfate	OS(S)(=O)=O	1188.4	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
Thiosulfate,1TMS,isomer #1	C[Si](C)(C)OS(=O)(=O)S	1259.2	Semi standard non polar	33892256
Thiosulfate,1TMS,isomer #1	C[Si](C)(C)OS(=O)(=O)S	1037.4	Standard non polar	33892256
Thiosulfate,1TMS,isomer #1	C[Si](C)(C)OS(=O)(=O)S	1891.1	Standard polar	33892256
Thiosulfate,1TMS,isomer #2	C[Si](C)(C)SS(=O)(=O)O	1290.3	Semi standard non polar	33892256
Thiosulfate,1TMS,isomer #2	C[Si](C)(C)SS(=O)(=O)O	1062.8	Standard non polar	33892256
Thiosulfate,1TMS,isomer #2	C[Si](C)(C)SS(=O)(=O)O	1934.9	Standard polar	33892256
Thiosulfate,2TMS,isomer #1	C[Si](C)(C)OS(=O)(=O)S[Si](C)(C)C	1334.9	Semi standard non polar	33892256
Thiosulfate,2TMS,isomer #1	C[Si](C)(C)OS(=O)(=O)S[Si](C)(C)C	1252.1	Standard non polar	33892256
Thiosulfate,2TMS,isomer #1	C[Si](C)(C)OS(=O)(=O)S[Si](C)(C)C	1674.5	Standard polar	33892256
Thiosulfate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OS(=O)(=O)S	1516.5	Semi standard non polar	33892256
Thiosulfate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OS(=O)(=O)S	1349.6	Standard non polar	33892256
Thiosulfate,1TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OS(=O)(=O)S	2070.6	Standard polar	33892256
Thiosulfate,1TBDMS,isomer #2	CC(C)(C)[Si](C)(C)SS(=O)(=O)O	1552.3	Semi standard non polar	33892256
Thiosulfate,1TBDMS,isomer #2	CC(C)(C)[Si](C)(C)SS(=O)(=O)O	1360.5	Standard non polar	33892256
Thiosulfate,1TBDMS,isomer #2	CC(C)(C)[Si](C)(C)SS(=O)(=O)O	2049.1	Standard polar	33892256
Thiosulfate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OS(=O)(=O)S[Si](C)(C)C(C)(C)C	1856.5	Semi standard non polar	33892256
Thiosulfate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OS(=O)(=O)S[Si](C)(C)C(C)(C)C	1770.5	Standard non polar	33892256
Thiosulfate,2TBDMS,isomer #1	CC(C)(C)[Si](C)(C)OS(=O)(=O)S[Si](C)(C)C(C)(C)C	1852.3	Standard polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - Thiosulfate GC-MS (Non-derivatized) - 70eV, Positive	splash10-03di-2900000000-0340aa179a944cddc03f	2017-09-20	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Thiosulfate GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - Thiosulfate GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Experimental LC-MS/MS	LC-MS/MS Spectrum - Thiosulfate Quattro_QQQ 10V, Positive-QTOF (Annotated)	splash10-00di-9200000000-8d6f9db7b85e719b5336	2018-05-17	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Thiosulfate Quattro_QQQ 25V, Positive-QTOF (Annotated)	splash10-05fr-9000000000-5140dc89fca222f5cb69	2018-05-17	HMDB team, MONA	View Spectrum
Experimental LC-MS/MS	LC-MS/MS Spectrum - Thiosulfate Quattro_QQQ 40V, Positive-QTOF (Annotated)	splash10-0ab9-9000000000-2876b0d2bddab26086e9	2018-05-17	HMDB team, MONA	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 10V, Positive-QTOF	splash10-03di-2900000000-cfd5e2fee5605aa6f365	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 20V, Positive-QTOF	splash10-03di-1900000000-14f35b6955762fa5ef9c	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 40V, Positive-QTOF	splash10-01pk-9300000000-6d71fc2acfdc5c953636	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 10V, Negative-QTOF	splash10-03di-0900000000-4fefeb50f8b5131bb095	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 20V, Negative-QTOF	splash10-03di-1900000000-25562aa85ac0e34c2f5b	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 40V, Negative-QTOF	splash10-03di-1900000000-c55a98b5b4d32b24a3cd	2015-09-15	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 10V, Positive-QTOF	splash10-01ot-9600000000-91b94305c2dea2ac1a55	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 20V, Positive-QTOF	splash10-01ot-9700000000-2a1ba4afd4c6e16c135f	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 40V, Positive-QTOF	splash10-0002-9000000000-788341845848b1bd60e2	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 10V, Negative-QTOF	splash10-03di-0900000000-8713d6562312e043b633	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 20V, Negative-QTOF	splash10-03di-0900000000-8713d6562312e043b633	2021-09-23	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Thiosulfate 40V, Negative-QTOF	splash10-03di-0900000000-8713d6562312e043b633	2021-09-23	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-16	Wishart Lab	View Spectrum

IR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)	2023-02-03	FELIX lab	View Spectrum
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)	2023-02-03	FELIX lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Mitochondria

Biospecimen Locations

Bile
Blood
Urine

Tissue Locations

Epidermis

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Bile	Detected and Quantified	1215 +/- 261 uM	Adult (>18 years old)	Not Specified	Normal	6600205	details
Blood	Detected and Quantified	100.8 +/- 9.811 uM	Adult (>18 years old)	Both	Normal	6600205	details
Blood	Detected and Quantified	1.5 (0.0-3.0) uM	Adult (>18 years old)	Both	Normal	15231289	details
Urine	Detected and Quantified	0.470-3.820 umol/mmol creatinine	Not Specified	Both	Normal	6945862	details
Urine	Detected and Quantified	2.09 +/- 0.84 umol/mmol creatinine	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Urine	Detected and Quantified	1.646 +/- 0.118 umol/mmol creatinine	Adult (>18 years old)	Both	Normal	6600205	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	150.0 (110.0-230.0) uM	Adult (>18 years old)	Both	Hydrogen sulfide fatal poisoning	15231289	details
Urine	Detected and Quantified	2.6 umol/mmol creatinine	Adult (>18 years old)	Female	Beta-mercaptolactate-cysteine Disulfiduria	6945862	details
Urine	Detected and Quantified	53 umol/mmol creatinine	Newborn (0-30 days old)	Not Specified	Molybdenum cofactor deficiency	8051926	details
Urine	Detected and Quantified	263 umol/mmol creatinine	Children (1-13 years old)	Not Specified	Molybdenum cofactor deficiency	8051926	details

Associated Disorders and Diseases

Disease References

Hydrogen sulfide poisoning
Kage S, Ikeda H, Ikeda N, Tsujita A, Kudo K: Fatal hydrogen sulfide poisoning at a dye works. Leg Med (Tokyo). 2004 Jul;6(3):182-6. [PubMed:15231289 ]
Molybdenum cofactor deficiency
van Gennip AH, Abeling NG, Stroomer AE, Overmars H, Bakker HD: The detection of molybdenum cofactor deficiency: clinical symptomatology and urinary metabolite profile. J Inherit Metab Dis. 1994;17(1):142-5. [PubMed:8051926 ]
Beta-mercaptolactate-cysteine Disulfiduria
Hannestad U, Martensson J, Sjodahl R, Sorbo B: 3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family. Biochem Med. 1981 Aug;26(1):106-14. [PubMed:6945862 ]

Associated OMIM IDs

249650 (Beta-mercaptolactate-cysteine Disulfiduria)

External Links

DrugBank ID

DB09499

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB034578

KNApSAcK ID

Not Available

Chemspider ID

22886

KEGG Compound ID

C05529

BioCyc ID

S2O3

BiGG ID

Not Available

Wikipedia Link

Thiosulfate

METLIN ID

Not Available

PubChem Compound

1085

PDB ID

Not Available

ChEBI ID

5587

Food Biomarker Ontology

Not Available

VMH ID

HC01501

MarkerDB ID

MDB00000125

Good Scents ID

Not Available

References

Synthesis Reference

Serikova, E. A.; Racheva, I. V. Method for producing sodium thiosulfate. U.S.S.R. (1986), CODEN: URXXAF SU 1279954 A1 19861230 Patent written in Russian.

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Willis CL, Cummings JH, Neale G, Gibson GR: Nutritional aspects of dissimilatory sulfate reduction in the human large intestine. Curr Microbiol. 1997 Nov;35(5):294-8. [PubMed:9462959 ]
Chatterjee BD, De PK, Sen T: Sucrose teepol tellurite agar: a new selective indicator medium for isolation of Vibrio species. J Infect Dis. 1977 Apr;135(4):654-8. [PubMed:856920 ]
Rikimaru T, Kondo M, Kajimura K, Hashimoto K, Oyamada K, Sagawa K, Tanoue S, Oizumi K: Bactericidal activities of commonly used antiseptics against multidrug-resistant mycobacterium tuberculosis. Dermatology. 2002;204 Suppl 1:15-20. [PubMed:12011515 ]
Maddocks JL, MacLachlan J: Application of new fluorescent thiol reagent to diagnosis of homocystinuria. Lancet. 1991 Oct 26;338(8774):1043-4. [PubMed:1681358 ]
Ivankovich AD, Braverman B, Stephens TS, Shulman M, Heyman HJ: Sodium thiosulfate disposition in humans: relation to sodium nitroprusside toxicity. Anesthesiology. 1983 Jan;58(1):11-7. [PubMed:6600205 ]
Kage S, Nagata T, Kudo K: Determination of thiosulfate in body fluids by GC and GC/MS. J Anal Toxicol. 1991 May-Jun;15(3):148-50. [PubMed:1943059 ]
Rikimaru T, Kondo M, Kondo S, Oizumi K: Bactericidal activities of povidone-iodine against Mycobacterium. Dermatology. 1997;195 Suppl 2:104-6. [PubMed:9403266 ]
Zewert TE, Pliquett UF, Vanbever R, Langer R, Weaver JC: Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule. Bioelectrochem Bioenerg. 1999 Oct;49(1):11-20. [PubMed:10619443 ]
Freyberg RH, Block WD, Levey S: METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS. I. HUMAN PLASMA AND SYNOVIAL FLUID CONCENTRATION AND URINARY EXCRETION OF GOLD DURING AND FOLLOWING TREATMENT WITH GOLD SODIUM THIOMALATE, GOLD SODIUM THIOSULFATE, AND COLLOIDAL GOLD SULFIDE. J Clin Invest. 1941 Jul;20(4):401-12. [PubMed:16694848 ]
Westerlund J, Pudek M, Schreiber WE: A rapid and accurate spectrofluorometric method for quantification and screening of urinary porphyrins. Clin Chem. 1988 Feb;34(2):345-51. [PubMed:3342508 ]
Yatzidis H: Gestational urinary hyperthiosulfaturia protects hypercalciuric normal pregnant women from nephrolithiasis. Int Urol Nephrol. 2004;36(3):445-9. [PubMed:15783122 ]
Rennels MB, Levine MM, Daya V, Angle P, Young C: Selective vs. nonselective media and direct plating vs. enrichment technique in isolation of Vibrio cholerae: recommendations for clinical laboratories. J Infect Dis. 1980 Sep;142(3):328-31. [PubMed:7003031 ]

Enzymes

Enzyme Details

1. 3-mercaptopyruvate sulfurtransferase

General function:: Involved in thiosulfate sulfurtransferase activity
Specific function:: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis.
Gene Name:: MPST
Uniprot ID:: P25325
Molecular weight:: 33178.15

Reactions

Thiosulfate + Hydrogen cyanide → Sulfite + Thiocyanate	details
3-Mercaptopyruvic acid + Sulfite → Thiosulfate + Pyruvic acid	details

Enzyme Details

2. Uridine 5'-monophosphate synthase

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: UMPS
Uniprot ID:: P11172
Molecular weight:: 52221.075

Enzyme Details

3. Thiosulfate sulfurtransferase

General function:: Involved in thiosulfate sulfurtransferase activity
Specific function:: Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.
Gene Name:: TST
Uniprot ID:: Q16762
Molecular weight:: 33428.69

Reactions

Thiosulfate + Hydrogen cyanide → Sulfite + Thiocyanate	details
3-Mercaptopyruvic acid + Sulfite → Thiosulfate + Pyruvic acid	details

Enzyme Details

4. Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1

General function:: Inorganic ion transport and metabolism
Specific function:: Possible role in tumorgenesis
Gene Name:: TSTD1
Uniprot ID:: Q8NFU3
Molecular weight:: 12530.1

Showing metabocard for Thiosulfate (HMDB0000257)

MOL for HMDB0000257 (Thiosulfate)

3D MOL for HMDB0000257 (Thiosulfate)

3D SDF for HMDB0000257 (Thiosulfate)

3D-SDF for HMDB0000257 (Thiosulfate)

PDB for HMDB0000257 (Thiosulfate)

3D PDB for HMDB0000257 (Thiosulfate)

SMILES for HMDB0000257 (Thiosulfate)

INCHI for HMDB0000257 (Thiosulfate)

Structure for HMDB0000257 (Thiosulfate)

3D Structure for HMDB0000257 (Thiosulfate)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra

IR Spectra

Enzymes

Reactions

Reactions