You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Showing metabocard for Hydroxyisocaproic acid (HMDB0000746)
|Detected and Quantified
|2005-11-16 15:48:42 UTC
|2022-03-07 02:49:06 UTC
|Secondary Accession Numbers
|Hydroxyisocaproic acid is an end product of leucine metabolism in human tissues such as muscle and connective tissue. It belongs to 2-hydroxycarboxylic acid group of amino acid metabolites (PMID 6434570 ). Hydroxyisocaproic acid functions as an “anti-catabolite” and is widely used in the body building community. Chronic alpha-hydroxyisocaproic acid treatment of rats has been shown to improve muscle recovery after immobilization-induced atrophy (PMID: 23757407 ). Additionally, a 4-week hydroxyisocaproic acid supplementation of 1.5 g a day was shown to lead to increases in muscle mass during an intensive training period among soccer athletes (PMID: 20051111 ). Hydroxyisocaproic acid has also shown some potential as a topical antibiotic (PMID: 22483561 ). Elevated levels of 2-hydroxyisocaproic acid have been found in the urine of patients with dihydrolipoyl dehydrogenase (E3) deficiency (PMID: 6688766 ). Hydroxyisocaproic acid is also elevated in maple syrup urine disease, a genetic disorder, and has been shown to accelerate lipid peroxidation. It may also be an indicator of oxidative stress (PMID: 11894849 ). Hydroxyisocaproic acid has been found to be a metabolite of Lactobacillus and fungal species (http://jultika.oulu.fi/files/isbn9789526211046.pdf).
|Average Molecular Weight
|Monoisotopic Molecular Weight
|CAS Registry Number
|Belongs to the class of organic compounds known as hydroxy fatty acids. These are fatty acids in which the chain bears a hydroxyl group.
|Lipids and lipid-like molecules
|Fatty acids and conjugates
|Hydroxy fatty acids
|Aliphatic acyclic compounds
|Experimental Molecular Properties
|Experimental Chromatographic Properties
Experimental Collision Cross Sections
|Predicted Molecular Properties
|Predicted Chromatographic Properties
Predicted Collision Cross Sections
Predicted Kovats Retention Indices
|Associated Disorders and Diseases
|Associated OMIM IDs
|Phenol Explorer Compound ID
|KEGG Compound ID
|Food Biomarker Ontology
|Good Scents ID
|Schmidt, E. G.; Peterson, W. H.; Fred, E. B. The formation of l-leucic acid in the acetone-butyl alcohol fermentation. Journal of Biological Chemistry (1924), 61 163-75.
|Material Safety Data Sheet (MSDS)