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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2022-09-22 17:44:53 UTC
HMDB IDHMDB0000897
Secondary Accession Numbers
  • HMDB00897
Metabolite Identification
Common Name7-Methylguanine
Description7-Methylguanine, also known as N7-me-g, belongs to the class of organic compounds known as hypoxanthines. Hypoxanthines are compounds containing the purine derivative 1H-purin-6(9H)-one. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. 7-Methylguanine exists in all eukaryotes, ranging from yeast to plants to humans. 7-Methylguanine has been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make 7-methylguanine a potential biomarker for the consumption of these foods. Based on a literature review a significant number of articles have been published on 7-Methylguanine.
Structure
Data?1582752163
Synonyms
ValueSource
2-Amino-1,7-dihydro-7-methyl-6H-purin-6-oneChEBI
2-Amino-7-methylhypoxanthineChEBI
N(7)-MethylguanineChEBI
2-Amino-1,7-dihydroxy-7-methyl-6H-purine-6-oneHMDB
2-Amino-6-hydroxy-7-methylpurineHMDB
7-Methyl-guanineHMDB
7-Methyl-guanine (8ci)HMDB
N-MethylguanineHMDB
N7-MethylguanineHMDB
7-Methylguanine, 14C-labeledHMDB
N2-MethylguanineHMDB
N7-Me-gHMDB
N(2)-MethylguanineHMDB
7-MethylguanineChEBI
Chemical FormulaC6H7N5O
Average Molecular Weight165.1527
Monoisotopic Molecular Weight165.065059871
IUPAC Name2-amino-7-methyl-6,7-dihydro-3H-purin-6-one
Traditional Name2-amino-7-methylhypoxanthine
CAS Registry Number578-76-7
SMILES
CN1C=NC2=C1C(=O)N=C(N)N2
InChI Identifier
InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)
InChI KeyFZWGECJQACGGTI-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hypoxanthines. Hypoxanthines are compounds containing the purine derivative 1H-purin-6(9H)-one. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassImidazopyrimidines
Sub ClassPurines and purine derivatives
Direct ParentHypoxanthines
Alternative Parents
Substituents
  • 6-oxopurine
  • Hypoxanthine
  • Aminopyrimidine
  • Pyrimidone
  • N-substituted imidazole
  • Pyrimidine
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Vinylogous amide
  • Azacycle
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Amine
  • Organopnictogen compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point370 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Baker136.61730932474
[M+H]+Baker134.33330932474
[M-H]-Not Available136.617http://allccs.zhulab.cn/database/detail?ID=AllCCS00001790
Predicted Molecular Properties
PropertyValueSource
Water Solubility6.12 g/LALOGPS
logP-0.62ALOGPS
logP-0.37ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)9.35ChemAxon
pKa (Strongest Basic)2.07ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area85.3 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity43.8 m³·mol⁻¹ChemAxon
Polarizability15.41 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+134.38931661259
DarkChem[M-H]-135.37131661259
AllCCS[M+H]+135.55432859911
AllCCS[M-H]-132.4232859911
DeepCCS[M+H]+133.54730932474
DeepCCS[M-H]-131.15130932474
DeepCCS[M-2H]-166.90230932474
DeepCCS[M+Na]+141.36230932474
AllCCS[M+H]+135.632859911
AllCCS[M+H-H2O]+131.132859911
AllCCS[M+NH4]+139.732859911
AllCCS[M+Na]+140.932859911
AllCCS[M-H]-132.432859911
AllCCS[M+Na-2H]-133.232859911
AllCCS[M+HCOO]-134.032859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
7-MethylguanineCN1C=NC2=C1C(=O)N=C(N)N22769.2Standard polar33892256
7-MethylguanineCN1C=NC2=C1C(=O)N=C(N)N21933.9Standard non polar33892256
7-MethylguanineCN1C=NC2=C1C(=O)N=C(N)N22150.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
7-Methylguanine,1TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C)[NH]22064.5Semi standard non polar33892256
7-Methylguanine,1TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C)[NH]22187.2Standard non polar33892256
7-Methylguanine,1TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C)[NH]23085.8Standard polar33892256
7-Methylguanine,1TMS,isomer #2CN1C=NC2=C1C(=O)N=C(N)N2[Si](C)(C)C1983.8Semi standard non polar33892256
7-Methylguanine,1TMS,isomer #2CN1C=NC2=C1C(=O)N=C(N)N2[Si](C)(C)C2119.3Standard non polar33892256
7-Methylguanine,1TMS,isomer #2CN1C=NC2=C1C(=O)N=C(N)N2[Si](C)(C)C3029.7Standard polar33892256
7-Methylguanine,2TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C)N2[Si](C)(C)C1976.5Semi standard non polar33892256
7-Methylguanine,2TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C)N2[Si](C)(C)C2116.7Standard non polar33892256
7-Methylguanine,2TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C)N2[Si](C)(C)C2721.1Standard polar33892256
7-Methylguanine,2TMS,isomer #2CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]21991.7Semi standard non polar33892256
7-Methylguanine,2TMS,isomer #2CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]22149.5Standard non polar33892256
7-Methylguanine,2TMS,isomer #2CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C)[Si](C)(C)C)[NH]22726.4Standard polar33892256
7-Methylguanine,3TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C)[Si](C)(C)C)N2[Si](C)(C)C2020.0Semi standard non polar33892256
7-Methylguanine,3TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C)[Si](C)(C)C)N2[Si](C)(C)C2168.4Standard non polar33892256
7-Methylguanine,3TMS,isomer #1CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C)[Si](C)(C)C)N2[Si](C)(C)C2400.5Standard polar33892256
7-Methylguanine,1TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C(C)(C)C)[NH]22273.3Semi standard non polar33892256
7-Methylguanine,1TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C(C)(C)C)[NH]22322.4Standard non polar33892256
7-Methylguanine,1TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C(C)(C)C)[NH]23085.6Standard polar33892256
7-Methylguanine,1TBDMS,isomer #2CN1C=NC2=C1C(=O)N=C(N)N2[Si](C)(C)C(C)(C)C2227.8Semi standard non polar33892256
7-Methylguanine,1TBDMS,isomer #2CN1C=NC2=C1C(=O)N=C(N)N2[Si](C)(C)C(C)(C)C2288.5Standard non polar33892256
7-Methylguanine,1TBDMS,isomer #2CN1C=NC2=C1C(=O)N=C(N)N2[Si](C)(C)C(C)(C)C3011.9Standard polar33892256
7-Methylguanine,2TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C(C)(C)C)N2[Si](C)(C)C(C)(C)C2417.6Semi standard non polar33892256
7-Methylguanine,2TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C(C)(C)C)N2[Si](C)(C)C(C)(C)C2532.2Standard non polar33892256
7-Methylguanine,2TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N[Si](C)(C)C(C)(C)C)N2[Si](C)(C)C(C)(C)C2757.6Standard polar33892256
7-Methylguanine,2TBDMS,isomer #2CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]22380.9Semi standard non polar33892256
7-Methylguanine,2TBDMS,isomer #2CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]22561.1Standard non polar33892256
7-Methylguanine,2TBDMS,isomer #2CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[NH]22756.1Standard polar33892256
7-Methylguanine,3TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N2[Si](C)(C)C(C)(C)C2604.0Semi standard non polar33892256
7-Methylguanine,3TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N2[Si](C)(C)C(C)(C)C2804.9Standard non polar33892256
7-Methylguanine,3TBDMS,isomer #1CN1C=NC2=C1C(=O)N=C(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)N2[Si](C)(C)C(C)(C)C2631.4Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 7-Methylguanine GC-MS (Non-derivatized) - 70eV, Positivesplash10-01bi-2900000000-b0a95cd14f249c6674502016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 7-Methylguanine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 7-Methylguanine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative-QTOFsplash10-03di-0900000000-6d69b62500523e3dc3d02012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative-QTOFsplash10-03di-0900000000-37d2717efb3cfd99a3a52012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative-QTOFsplash10-0a4i-1900000000-9b6a6193e87ed7391bfd2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative-QTOFsplash10-0a4i-2900000000-8bc29ce14fc996e59b372012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative-QTOFsplash10-0a4i-6900000000-b9b860095178bfbd4cd42012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , negative-QTOFsplash10-03di-0900000000-6d69b62500523e3dc3d02017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , negative-QTOFsplash10-03di-0900000000-2105f1b548050728fb412017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , negative-QTOFsplash10-0a4i-1900000000-9b6a6193e87ed7391bfd2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , negative-QTOFsplash10-0a4i-2900000000-8bc29ce14fc996e59b372017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , negative-QTOFsplash10-0a4i-6900000000-b9b860095178bfbd4cd42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine 40V, Negative-QTOFsplash10-0a4l-9600000000-c64af20070e7df4770272021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine 30V, Negative-QTOFsplash10-0a4i-6900000000-23c5e399ce7807914ece2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine 10V, Negative-QTOFsplash10-03di-1900000000-2974101ec42c9398ae0e2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine 20V, Negative-QTOFsplash10-0a4i-3900000000-6f0fe1c22832890717122021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-014i-0900000000-9467edfe6e5fe41d80c72012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-0002-0900000000-248230263bb02a17634d2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-014i-9000000000-64ba12b6ac3ae920980e2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive-QTOFsplash10-00kb-1900000000-0d0f6cc2cd44562b23232012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive-QTOFsplash10-00di-9500000000-80f25018b3b2b6146ab02012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive-QTOFsplash10-00di-9600000000-ab600e6988ac4e56e3212012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive-QTOFsplash10-00dj-9400000000-e929965f6c63f59fcb152012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive-QTOFsplash10-014j-9000000000-fa82f4a1c9751a539c262012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , positive-QTOFsplash10-00kb-1900000000-61125a8802327f88d32a2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , positive-QTOFsplash10-00di-9500000000-80f25018b3b2b6146ab02017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 7-Methylguanine LC-ESI-QQ , positive-QTOFsplash10-00di-9600000000-8ea90be38587918e75522017-09-14HMDB team, MONAView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue Locations
  • Leukocyte
  • Placenta
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.129 +/- 0.024 uMAdult (>18 years old)BothNormal details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
UrineDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothColorectal Cancer details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal cancer
details
Associated Disorders and Diseases
Disease References
Colorectal cancer
  1. Sinha R, Ahn J, Sampson JN, Shi J, Yu G, Xiong X, Hayes RB, Goedert JJ: Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One. 2016 Mar 25;11(3):e0152126. doi: 10.1371/journal.pone.0152126. eCollection 2016. [PubMed:27015276 ]
  2. Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022305
KNApSAcK IDNot Available
Chemspider ID10883
KEGG Compound IDC02242
BioCyc IDCPD0-2377
BiGG IDNot Available
Wikipedia Link7-Methylguanine
METLIN IDNot Available
PubChem Compound11361
PDB IDNot Available
ChEBI ID28664
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceAdams, Benjamin L. De-D-ribosylation of 7-alkylpurine D-ribonucleosides by a reduction-displacement procedure. Conversion of 7-methylguanosine into 7-methylguanine. Nucleic Acid Chem. (1978), 2 615-17.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Mustonen R, Hemminki K: 7-Methylguanine levels in DNA of smokers' and non-smokers' total white blood cells, granulocytes and lymphocytes. Carcinogenesis. 1992 Nov;13(11):1951-5. [PubMed:1423861 ]
  2. Eder E: Intraindividual variations of DNA adduct levels in humans. Mutat Res. 1999 Mar 8;424(1-2):249-61. [PubMed:10064865 ]
  3. van Delft JH, van den Ende AM, Keizer HJ, Ouwerkerk J, Baan RA: Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine. Carcinogenesis. 1992 Jul;13(7):1257-9. [PubMed:1638694 ]
  4. Kumar R, Hemminki K: Separation of 7-methyl- and 7-(2-hydroxyethyl)-guanine adducts in human DNA samples using a combination of TLC and HPLC. Carcinogenesis. 1996 Mar;17(3):485-92. [PubMed:8631134 ]
  5. Chao MR, Wang CJ, Yang HH, Chang LW, Hu CW: Rapid and sensitive quantification of urinary N7-methylguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with on-line solid-phase extraction. Rapid Commun Mass Spectrom. 2005;19(17):2427-32. [PubMed:16059882 ]
  6. Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Enzymes

General function:
Involved in catalytic activity
Specific function:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions
Gene Name:
MPG
Uniprot ID:
P29372
Molecular weight:
32868.4