Showing metabocard for Thymidine 5'-triphosphate (HMDB0001342)

General function:

Involved in hydrolase activity

Specific function:

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Gene Name:

ENTPD1

Uniprot ID:

P49961

Molecular weight:

58706.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

Gene Name:

CANT1

Uniprot ID:

Q8WVQ1

Molecular weight:

44839.24

General function:

Involved in hydrolase activity

Specific function:

Has a threefold preference for the hydrolysis of ATP over ADP.

Gene Name:

ENTPD3

Uniprot ID:

O75355

Molecular weight:

59104.76

Reactions

General function:

Involved in ATP binding

Specific function:

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Gene Name:

UCK1

Uniprot ID:

Q9HA47

Molecular weight:

22760.43

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).

Gene Name:

NME4

Uniprot ID:

O00746

Molecular weight:

20658.45

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.

Gene Name:

NME1

Uniprot ID:

P15531

Molecular weight:

17148.635

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Gene Name:

NME7

Uniprot ID:

Q9Y5B8

Molecular weight:

42491.365

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Name:

NME2

Uniprot ID:

P22392

Molecular weight:

30136.92

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

Gene Name:

NME3

Uniprot ID:

Q13232

Molecular weight:

19014.85

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Gene Name:

NME6

Uniprot ID:

O75414

Molecular weight:

22002.965

Reactions