Showing metabocard for Ibuprofen (HMDB0001925)

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Gene Name:

MAOB

Uniprot ID:

P27338

Molecular weight:

58762.475

General function:

Involved in oxidoreductase activity

Specific function:

Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.

Gene Name:

AKR1C1

Uniprot ID:

Q04828

Molecular weight:

36788.02

General function:

Involved in oxidoreductase activity

Specific function:

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.

Gene Name:

AKR1C2

Uniprot ID:

P52895

Molecular weight:

15747.91

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.

Gene Name:

UGT1A1

Uniprot ID:

P22309

Molecular weight:

59590.91

Reactions

General function:

Involved in peroxidase activity

Specific function:

Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

Gene Name:

PTGS2

Uniprot ID:

P35354

Molecular weight:

68995.625

General function:

Involved in peroxidase activity

Specific function:

May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Gene Name:

PTGS1

Uniprot ID:

P23219

Molecular weight:

68685.82

General function:

Involved in monooxygenase activity

Specific function:

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.

Gene Name:

CYP2C9

Uniprot ID:

P11712

Molecular weight:

55627.365

General function:

Involved in transport

Specific function:

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

Gene Name:

ALB

Uniprot ID:

P02768

Molecular weight:

69365.9