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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2006-08-12 20:46:08 UTC
Update Date2021-10-13 04:41:43 UTC
HMDB IDHMDB0003441
Secondary Accession Numbers
  • HMDB03441
Metabolite Identification
Common NameCinnamaldehyde
DescriptionCinnamaldehyde is the aldehyde that gives cinnamon its flavor and odor. Cinnamaldehyde occurs naturally in the bark of cinnamon trees and other species of the genus Cinnamomum like camphor and cassia. These trees are the natural source of cinnamon, and the essential oil of cinnamon bark is about 90% cinnamaldehyde. Cinnamaldehyde is also used as a fungicide. Proven effective on over 40 different crops, cinnamaldehyde is typically applied to the root systems of plants. Its low toxicity and well-known properties make it ideal for agriculture. To a lesser extent, cinnamaldehyde is an effective insecticide, and its scent is also known to repel animals like cats and dogs. Cinnamaldehyde is also known as a corrosion inhibitor for steel and other ferrous alloys in corrosive fluids. It can be used in combination with additional components such as dispersing agents, solvents and other surfactants. Concentrated cinnamaldehyde is a skin irritant, and the chemical is toxic in large doses, but no agencies suspect the compound is a carcinogen or poses a long-term health hazard. Most cinnamaldehyde is excreted in urine as cinnamic acid, an oxidized form of cinnamaldehyde.
Structure
Data?1582752277
Synonyms
ValueSource
(e)-3-Phenyl-2-propenalChEBI
(e)-3-Phenyl-propenalChEBI
(e)-3-PhenylpropenalChEBI
(e)-Cinnamic aldehydeChEBI
(e)-Phenylvinyl aldehydeChEBI
3-PhenylacrylaldehydeChEBI
trans-Cinnamic aldehydeChEBI
(e)-CinnamaldehydeHMDB
(2E)-3-Phenyl-2-propenalHMDB
(2E)-3-PhenylacrylaldehydeHMDB
3-FenylpropenalHMDB
3-Phenyl-2-propen-1-alHMDB
3-Phenyl-2-propenaldehydeHMDB
3-PhenylacroleinHMDB
3-Phenylprop-2-enalHMDB
3-PhenylpropenalHMDB
BenzylideneacetaldehydeHMDB
beta-PhenylcroleinHMDB
CinnamalHMDB
Cinnamic aldehydeHMDB
Cinnamyl aldehydeHMDB
CinnamylaldehydeHMDB
CinnemaldehydeHMDB
trans-3-Phenyl-2-propenalHMDB
trans-CinnamaldehydeHMDB
trans-CinnamylaldehydeHMDB
beta-PhenylacroleinHMDB
SupercinnamaldehydeHMDB
trans-3-Phenylprop-2-enaldehydeHMDB
3-Phenylprop-2-enaldehydeHMDB
Cinnamic aldehyde, (e)-isomerHMDB
2E)-3-Phenyl-2-propenalPhytoBank
(E)-3-PhenylacroleinPhytoBank
(E)-3-Phenylprop-2-en-1-alPhytoBank
(E)-3-Phenylprop-2-enalPhytoBank
(E)-3-Phenylprop-2-enonePhytoBank
E-Cinnamyl aldehydePhytoBank
trans-3-PhenylpropenalPhytoBank
trans-BenzenepropenalPhytoBank
3-Phenyl-2-propenalPhytoBank
3-Phenyl-2-propene-1-alPhytoBank
Chemical FormulaC9H8O
Average Molecular Weight132.1592
Monoisotopic Molecular Weight132.057514878
IUPAC Name(2E)-3-phenylprop-2-enal
Traditional Namecinnamal
CAS Registry Number104-55-2
SMILES
O=C\C=C\C1=CC=CC=C1
InChI Identifier
InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
InChI KeyKJPRLNWUNMBNBZ-QPJJXVBHSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as cinnamaldehydes. These are organic aromatic compounds containing a cinnamlaldehyde moiety, consisting of a benzene and an aldehyde group to form 3-phenylprop-2-enal.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCinnamaldehydes
Sub ClassNot Available
Direct ParentCinnamaldehydes
Alternative Parents
Substituents
  • Cinnamaldehyde
  • Styrene
  • Benzenoid
  • Monocyclic benzene moiety
  • Enal
  • Alpha,beta-unsaturated aldehyde
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aldehyde
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateLiquid
Experimental Molecular Properties
PropertyValueReference
Melting Point-7.5 °CNot Available
Boiling Point248.00 °C. @ 760.00 mm HgThe Good Scents Company Information System
Water Solubility1.42 mg/mL at 25 °CNot Available
LogP1.90HANSCH,C ET AL. (1995)
Experimental Spectral Properties

Experimental Collision Cross Sections

PredictorAdduct TypeData SourceCCS Value (Å2)Reference
DeepCCS[M+H]+Baker134.25130932474
AllCCS[M+H]+Not Available134.251http://allccs.zhulab.cn/database/detail?ID=AllCCS00002051
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.41 g/LALOGPS
logP10(2) g/LALOGPS
logP10(1.98) g/LChemAxon
logS10(-2.5) g/LALOGPS
pKa (Strongest Basic)-4.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area17.07 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity42.13 m³·mol⁻¹ChemAxon
Polarizability14.48 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+131.8331661259
DarkChem[M-H]-127.69831661259

Predicted Kovats Retention Indices

Not Available
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde GC-MS (Non-derivatized)splash10-0059-3900000000-52db83b595237437ab082014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde EI-B (Non-derivatized)splash10-0f89-5900000000-540c43f6893b35e8a1052017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde EI-B (Non-derivatized)splash10-0f89-5900000000-482f8b5c30c53689d8eb2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde EI-B (Non-derivatized)splash10-001i-3900000000-9d274f5e3981ab6626502017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde EI-B (Non-derivatized)splash10-001i-0900000000-4f0ad7748ac21b7320c92017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde EI-B (Non-derivatized)splash10-0f89-6900000000-ecaba4b9d657020c3f4c2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde CI-B (Non-derivatized)splash10-001i-0900000000-c02b7869dea8f1113cb42017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde EI-B (Non-derivatized)splash10-001i-2900000000-d89aa99ef7a6ae16b9422017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde EI-B (Non-derivatized)splash10-0ugi-8900000000-14f14e29c81360ebdd4b2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Cinnamaldehyde GC-MS (Non-derivatized)splash10-0059-3900000000-52db83b595237437ab082017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Cinnamaldehyde GC-MS (Non-derivatized) - 70eV, Positivesplash10-0f89-4900000000-e9eb0053986096f21c832016-09-22Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Cinnamaldehyde GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-0a59-5900000000-a125425df0f09bb011292012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-056r-9300000000-043ea317ed08a1cbacfb2012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-004i-9000000000-39ab07ef5d737e8516712012-07-25HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde EI-B (HITACHI RMU-7M) , Positive-QTOFsplash10-0f89-5900000000-f27dd11a8900d729bd192012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde EI-B (JEOL JMS-D-3000) , Positive-QTOFsplash10-0f89-5900000000-4e11cf955911f9ca7da22012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde EI-B (SHIMADZU QP-1000) , Positive-QTOFsplash10-001i-3900000000-9d274f5e3981ab6626502012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde EI-B (SHIMADZU QP-1000) , Positive-QTOFsplash10-001i-0900000000-4f0ad7748ac21b7320c92012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde EI-B (HITACHI RMU-6M) , Positive-QTOFsplash10-0f89-6900000000-e363e674a4ec6e092f262012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde CI-B (HITACHI M-80) , Positive-QTOFsplash10-001i-0900000000-c02b7869dea8f1113cb42012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde EI-B (HITACHI RMU-6M) , Positive-QTOFsplash10-001i-2900000000-7339e3ff66ab63ba34092012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde EI-B (HITACHI M-80B) , Positive-QTOFsplash10-0ugi-8900000000-1b72d0d216af153654442012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive-QTOFsplash10-067i-2900000000-76d2db81f3822a698f0a2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Cinnamaldehyde LC-ESI-QTOF , positive-QTOFsplash10-067i-2900000000-76d2db81f3822a698f0a2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 10V, Positive-QTOFsplash10-001i-1900000000-4b1b083c8fdb2a27206b2016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 20V, Positive-QTOFsplash10-00lr-2900000000-eee6045375789bd7b5112016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 40V, Positive-QTOFsplash10-0f6x-9400000000-ffef407879854d06bd7e2016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 10V, Negative-QTOFsplash10-001i-0900000000-074611feed644fd89c072016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 20V, Negative-QTOFsplash10-001i-0900000000-cbf5bec188b738c514af2016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 40V, Negative-QTOFsplash10-01p6-9600000000-5eb930cf87b199a5f4492016-09-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 10V, Negative-QTOFsplash10-0udi-0900000000-827b27666b5028c8cf772021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 20V, Negative-QTOFsplash10-0udi-0900000000-138b8c24fd394024a31a2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 40V, Negative-QTOFsplash10-004i-9200000000-93f143b30bbb2b4ff7782021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 10V, Positive-QTOFsplash10-00lu-2900000000-eda42d3592c23cd1e4bd2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 20V, Positive-QTOFsplash10-0udi-5900000000-5757a78bf103c73ab4342021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Cinnamaldehyde 40V, Positive-QTOFsplash10-0fvi-9300000000-8784eab3c86fc7a1a7212021-09-23Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, CD3OD, experimental)2012-12-05Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane (predicted from logP)
Biospecimen Locations
  • Feces
Tissue Locations
  • Epidermis
  • Neuron
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB030727
KNApSAcK IDC00002725
Chemspider ID553117
KEGG Compound IDC00903
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkCinnamaldehyde
METLIN ID6931
PubChem Compound637511
PDB IDNot Available
ChEBI ID16731
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1092691
References
Synthesis ReferenceLiu, Xue-mei. Synthesis of cinnamaldehyde. Qufu Shifan Daxue Xuebao, Ziran Kexueban (2005), 31(2), 96-98.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A: Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004 Mar 25;41(6):849-57. [PubMed:15046718 ]
  2. Muller G, Biering A, Graubaum K, Jeschkeit H, Neubert K, Kleine R, Klapperstuck M: [The PABA test]. Dtsch Z Verdau Stoffwechselkr. 1984;44(5):219-31. [PubMed:6334604 ]
  3. Smith CK, Moore CA, Elahi EN, Smart AT, Hotchkiss SA: Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol. Toxicol Appl Pharmacol. 2000 Nov 1;168(3):189-99. [PubMed:11042091 ]
  4. Smith CK, Cheung C, Elahi EN, Hotchkiss SA: High-performance liquid chromatography method for the quantification of non-radiolabelled cinnamic compounds in analytes derived from human skin absorption and metabolism experiments. J Chromatogr B Biomed Sci Appl. 2001 Jul 15;758(2):249-64. [PubMed:11486835 ]
  5. Bruze M, Johansen JD, Andersen KE, Frosch P, Lepoittevin JP, Rastogi S, Wakelin S, White I, Menne T: Deodorants: an experimental provocation study with cinnamic aldehyde. J Am Acad Dermatol. 2003 Feb;48(2):194-200. [PubMed:12582388 ]