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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-13 10:28:32 UTC
Update Date2020-02-26 21:24:57 UTC
HMDB IDHMDB0004081
Secondary Accession Numbers
  • HMDB04081
Metabolite Identification
Common Name6-Hydroxymelatonin
Description6-Hydroxymelatonin, also known as lopac-H-0627, belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group. 6-Hydroxymelatonin is considered to be a practically insoluble (in water) and relatively neutral molecule. 6-Hydroxymelatonin has been found in human liver and kidney tissues, and has also been detected in multiple biofluids, such as urine and blood. Within the cell, 6-hydroxymelatonin is primarily located in the cytoplasm. 6-Hydroxymelatonin is the main primary metabolite that can be biosynthesized from melatonin through its interaction with the enzyme cytochrome P450 (CYP) 1A2 (PMID: 11452239 ). In humans, 6-hydroxymelatonin is involved in the tryptophan metabolism pathway.
Structure
Data?1582752297
Synonyms
ValueSource
Lopac-H-0627ChEBI
6-OxymelatoninHMDB
6-Hydroxy-N-acetyl-5-methoxytryptamineHMDB
6-Hydroxy-N-acetyl-5-methoxytryptamine HMDB
Chemical FormulaC13H16N2O3
Average Molecular Weight248.2777
Monoisotopic Molecular Weight248.116092388
IUPAC NameN-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
Traditional NameN-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
CAS Registry Number2208-41-5
SMILES
COC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C1
InChI Identifier
InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
InChI KeyOMYMRCXOJJZYKE-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassIndoles and derivatives
Sub ClassHydroxyindoles
Direct ParentHydroxyindoles
Alternative Parents
Substituents
  • Hydroxyindole
  • 3-alkylindole
  • Indole
  • Anisole
  • Alkyl aryl ether
  • 1-hydroxy-2-unsubstituted benzenoid
  • Substituted pyrrole
  • Benzenoid
  • Pyrrole
  • Heteroaromatic compound
  • Azacycle
  • Ether
  • Carboximidic acid derivative
  • Carboximidic acid
  • Propargyl-type 1,3-dipolar organic compound
  • Organic 1,3-dipolar compound
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organic nitrogen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organopnictogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Process

Naturally occurring process

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.47 g/LALOGPS
logP0.8ALOGPS
logP0.84ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)9.29ChemAxon
pKa (Strongest Basic)-0.94ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area74.35 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity68.26 m³·mol⁻¹ChemAxon
Polarizability26.65 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+155.9131661259
DarkChem[M-H]-158.63431661259
DeepCCS[M+H]+158.10530932474
DeepCCS[M-H]-155.74730932474
DeepCCS[M-2H]-188.63330932474
DeepCCS[M+Na]+164.19830932474
AllCCS[M+H]+156.832859911
AllCCS[M+H-H2O]+153.132859911
AllCCS[M+NH4]+160.232859911
AllCCS[M+Na]+161.232859911
AllCCS[M-H]-160.432859911
AllCCS[M+Na-2H]-160.532859911
AllCCS[M+HCOO]-160.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
6-HydroxymelatoninCOC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C13864.9Standard polar33892256
6-HydroxymelatoninCOC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C12537.2Standard non polar33892256
6-HydroxymelatoninCOC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C12596.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
6-Hydroxymelatonin,1TMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C)[NH]C=C2CCNC(C)=O2618.3Semi standard non polar33892256
6-Hydroxymelatonin,1TMS,isomer #2COC1=CC2=C(C=C1O)N([Si](C)(C)C)C=C2CCNC(C)=O2667.8Semi standard non polar33892256
6-Hydroxymelatonin,1TMS,isomer #3COC1=CC2=C(C=C1O)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C2542.7Semi standard non polar33892256
6-Hydroxymelatonin,2TMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C2542.1Semi standard non polar33892256
6-Hydroxymelatonin,2TMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C2696.7Standard non polar33892256
6-Hydroxymelatonin,2TMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C2934.4Standard polar33892256
6-Hydroxymelatonin,2TMS,isomer #2COC1=CC2=C(C=C1O[Si](C)(C)C)N([Si](C)(C)C)C=C2CCNC(C)=O2647.4Semi standard non polar33892256
6-Hydroxymelatonin,2TMS,isomer #2COC1=CC2=C(C=C1O[Si](C)(C)C)N([Si](C)(C)C)C=C2CCNC(C)=O2566.2Standard non polar33892256
6-Hydroxymelatonin,2TMS,isomer #2COC1=CC2=C(C=C1O[Si](C)(C)C)N([Si](C)(C)C)C=C2CCNC(C)=O2948.3Standard polar33892256
6-Hydroxymelatonin,2TMS,isomer #3COC1=CC2=C(C=C1O)N([Si](C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C2558.6Semi standard non polar33892256
6-Hydroxymelatonin,2TMS,isomer #3COC1=CC2=C(C=C1O)N([Si](C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C2783.4Standard non polar33892256
6-Hydroxymelatonin,2TMS,isomer #3COC1=CC2=C(C=C1O)N([Si](C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C2986.3Standard polar33892256
6-Hydroxymelatonin,3TMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C)N([Si](C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C2593.0Semi standard non polar33892256
6-Hydroxymelatonin,3TMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C)N([Si](C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C2690.1Standard non polar33892256
6-Hydroxymelatonin,3TMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C)N([Si](C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C2753.6Standard polar33892256
6-Hydroxymelatonin,1TBDMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)[NH]C=C2CCNC(C)=O2877.6Semi standard non polar33892256
6-Hydroxymelatonin,1TBDMS,isomer #2COC1=CC2=C(C=C1O)N([Si](C)(C)C(C)(C)C)C=C2CCNC(C)=O2903.1Semi standard non polar33892256
6-Hydroxymelatonin,1TBDMS,isomer #3COC1=CC2=C(C=C1O)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C2786.9Semi standard non polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3009.7Semi standard non polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3118.4Standard non polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)[NH]C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3087.6Standard polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #2COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C=C2CCNC(C)=O3127.7Semi standard non polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #2COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C=C2CCNC(C)=O2997.5Standard non polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #2COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C=C2CCNC(C)=O3072.9Standard polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #3COC1=CC2=C(C=C1O)N([Si](C)(C)C(C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3011.4Semi standard non polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #3COC1=CC2=C(C=C1O)N([Si](C)(C)C(C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3153.0Standard non polar33892256
6-Hydroxymelatonin,2TBDMS,isomer #3COC1=CC2=C(C=C1O)N([Si](C)(C)C(C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3088.6Standard polar33892256
6-Hydroxymelatonin,3TBDMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3225.4Semi standard non polar33892256
6-Hydroxymelatonin,3TBDMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3276.9Standard non polar33892256
6-Hydroxymelatonin,3TBDMS,isomer #1COC1=CC2=C(C=C1O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)C=C2CCN(C(C)=O)[Si](C)(C)C(C)(C)C3030.3Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - 6-Hydroxymelatonin GC-MS (3 TMS)splash10-00di-1659000000-71cdfc5bdcf432c9a84a2014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 6-Hydroxymelatonin GC-MS (Non-derivatized)splash10-00di-1659000000-71cdfc5bdcf432c9a84a2017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 6-Hydroxymelatonin GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9670000000-71b021cf86103b186db22017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 6-Hydroxymelatonin GC-MS (1 TMS) - 70eV, Positivesplash10-05fv-7093000000-311814a60377cf77abd42017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 6-Hydroxymelatonin GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 6-Hydroxymelatonin LC-ESI-qTof , Positive-QTOFsplash10-0a4i-3900000000-533a23d884233d4fd9052017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 6-Hydroxymelatonin , positive-QTOFsplash10-0a4i-3900000000-533a23d884233d4fd9052017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 10V, Positive-QTOFsplash10-0a4j-0190000000-fc098aa93958c18074a62016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 20V, Positive-QTOFsplash10-0a4i-0970000000-669a6bd5f7e0091b9ca42016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 40V, Positive-QTOFsplash10-03fu-1900000000-ffc8f8f8477bce0884932016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 10V, Negative-QTOFsplash10-0002-1090000000-b17e668c7f1e41db8d302016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 20V, Negative-QTOFsplash10-0a4i-3490000000-92983db3c1d0bece458c2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 40V, Negative-QTOFsplash10-052f-9200000000-3ac4e7417916c5b2e2f52016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 10V, Positive-QTOFsplash10-0006-0920000000-7ed799d3e8693bde62e72021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 20V, Positive-QTOFsplash10-0006-0910000000-eb01005068ed6043a4542021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 40V, Positive-QTOFsplash10-08fu-0900000000-2d6ad727babdb3e4bb6e2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 10V, Negative-QTOFsplash10-0002-0090000000-dff205e638af0877604b2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 20V, Negative-QTOFsplash10-0a4l-9200000000-d8c0a556f4b94d8320172021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 6-Hydroxymelatonin 40V, Negative-QTOFsplash10-06r5-4940000000-23e212544ac34c9c55d62021-09-24Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen Locations
  • Blood
  • Urine
Tissue Locations
  • Adrenal Medulla
  • Kidney
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.00024 (0.00008-0.0004) uMAdult (>18 years old)BothNormal details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableNormal
      Not Available
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023304
KNApSAcK IDNot Available
Chemspider ID1794
KEGG Compound IDC05643
BioCyc IDNot Available
BiGG ID46185
Wikipedia Link6-Hydroxymelatonin
METLIN ID7013
PubChem Compound1864
PDB IDNot Available
ChEBI ID2198
Food Biomarker OntologyNot Available
VMH ID6HOXMELATN
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceKaram, Omar; Zunino, Fabien; Chagnaut, Vincent; Jouannetaud, Marie Paule; Jacquesy, Jean Claude. An efficient synthesis of 6-hydroxymelatonin, a human metabolite of melatonin. Tetrahedron Letters (2003), 44(7), 1511-1513.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Higa S, Suzuki T, Sakoda S, Kishimoto S, Takaba Y, Nakajima A, Markey SP: Disturbed function of the pineal gland in familial amyloid polyneuropathy. J Neural Transm. 1987;69(1-2):97-103. [PubMed:3035087 ]
  2. Bojkowski CJ, Arendt J, Shih MC, Markey SP: Melatonin secretion in humans assessed by measuring its metabolite, 6-sulfatoxymelatonin. Clin Chem. 1987 Aug;33(8):1343-8. [PubMed:3608151 ]
  3. Whitson PA, Putcha L, Chen YM, Baker E: Melatonin and cortisol assessment of circadian shifts in astronauts before flight. J Pineal Res. 1995 Apr;18(3):141-7. [PubMed:7562371 ]
  4. Nowak R, McMillen IC, Redman J, Short RV: The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity. Clin Endocrinol (Oxf). 1987 Oct;27(4):445-52. [PubMed:3436070 ]
  5. Bruce J, Tamarkin L, Riedel C, Markey S, Oldfield E: Sequential cerebrospinal fluid and plasma sampling in humans: 24-hour melatonin measurements in normal subjects and after peripheral sympathectomy. J Clin Endocrinol Metab. 1991 Apr;72(4):819-23. [PubMed:2005207 ]
  6. Francis PL, Leone AM, Young IM, Stovell P, Silman RE: Gas chromatographic-mass spectrometric assay for 6-hydroxymelatonin sulfate and 6-hydroxymelatonin glucuronide in urine. Clin Chem. 1987 Apr;33(4):453-7. [PubMed:3829375 ]
  7. Hartter S, Ursing C, Morita S, Tybring G, von Bahr C, Christensen M, Rojdmark S, Bertilsson L: Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clin Pharmacol Ther. 2001 Jul;70(1):10-6. [PubMed:11452239 ]

Only showing the first 10 proteins. There are 24 proteins in total.

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
General function:
Involved in monooxygenase activity
Specific function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular weight:
57756.285
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
Gene Name:
CYP1B1
Uniprot ID:
Q16678
Molecular weight:
60845.33
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular weight:
55710.075
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Gene Name:
CYP2F1
Uniprot ID:
P24903
Molecular weight:
55500.64
General function:
Involved in monooxygenase activity
Specific function:
Not Available
Gene Name:
CYP4X1
Uniprot ID:
Q8N118
Molecular weight:
58874.62
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular weight:
56277.81

Only showing the first 10 proteins. There are 24 proteins in total.