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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2006-08-14 00:33:07 UTC
Update Date2022-03-07 02:49:21 UTC
HMDB IDHMDB0004690
Secondary Accession Numbers
  • HMDB04690
Metabolite Identification
Common NameHepoxilin B3
DescriptionHepoxilin B3 is a normal human epidermis eicosanoid. Hepoxilin B3 is dramatically elevated in psoriatic lesions. The primary biological action of the hepoxilins appears to relate to their ability to release calcium from intracellular stores through a receptor-mediated action. The receptor is intracellular, and appears to be G-protein coupled. The conversion of hepoxilin into its omega-hydroxy catabolite has recently been demonstrated through the action of an omega-hydroxylase. This enzyme is different from that which oxidizes leukotriene B4, as the former activity is lost when the cell is disrupted, while leukotriene B4-catabolic activity is recovered in both the intact and disrupted cell. Additionally, hepoxilin catabolism is inhibited by CCCP, a mitochondrial uncoupler, while leukotriene catabolism is unaffected. As hepoxilins cause the translocation of calcium from intracellular stores in the endoplasmic reticulum to the mitochondria, it is speculated that hepoxilin omega-oxidation takes place in the mitochondria, and the omega-oxidation product facilitates accumulation of the elevated cytosolic calcium by the mitochondria. (PMID 10692117 , 11851887 , 10086189 ).
Structure
Data?1582752312
Synonyms
ValueSource
(5Z,8Z,14Z)-(11S,12S)-11,12-Epoxy-10-hydroxyeicosa-5,8,14-trienoic acidKegg
(5Z,8Z,14Z)-(11S,12S)-11,12-Epoxy-10-hydroxyicosa-5,8,14-trienoic acidKegg
(5Z,8Z,14Z)-(11S,12S)-11,12-Epoxy-10-hydroxyeicosa-5,8,14-trienoateGenerator
(5Z,8Z,14Z)-(11S,12S)-11,12-Epoxy-10-hydroxyicosa-5,8,14-trienoateGenerator
10-Hydroxy-11,12-epoxyeicosa-5,8,14-trienoic acidHMDB
EPHETAHMDB
Hepoxilin bHMDB
Threo-hepoxilin b3HMDB
Erythro-hepoxilin b3HMDB
(5Z,8Z)-10-Hydroxy-10-{(2R,3S)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl}deca-5,8-dienoateHMDB
(5Z,8Z)-10-Hydroxy-10-{(2R,3S)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl}deca-5,8-dienoic acidHMDB
(5Z,8Z,14Z)-(11R,12S)-11,12-Epoxy-10-hydroxyeicosa-5,8,14-trienoateHMDB
(5Z,8Z,14Z)-(11R,12S)-11,12-Epoxy-10-hydroxyeicosa-5,8,14-trienoic acidHMDB
(5Z,8Z,14Z)-(11R,12S)-11,12-Epoxy-10-hydroxyeicosa-5,8,14-trienoicacidHMDB
(5Z,8Z,14Z)-(11R,12S)-11,12-Epoxy-10-hydroxyicosa-5,8,14-trienoateHMDB
(5Z,8Z,14Z)-(11R,12S)-11,12-Epoxy-10-hydroxyicosa-5,8,14-trienoic acidHMDB
(5Z,8Z,14Z)-(11R,12S)-11,12-Epoxy-10-hydroxyicosa-5,8,14-trienoicacidHMDB
10-Hydroxy-11R,12S-epoxy-5Z,8Z,14Z-eicosatrienoateHMDB
10-Hydroxy-11R,12S-epoxy-5Z,8Z,14Z-eicosatrienoic acidHMDB
Chemical FormulaC20H32O4
Average Molecular Weight336.4657
Monoisotopic Molecular Weight336.230059512
IUPAC Name(5Z,8Z)-10-hydroxy-10-[(2R,3S)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl]deca-5,8-dienoic acid
Traditional Nameepheta
CAS Registry NumberNot Available
SMILES
CCCCC\C=C/C[C@@H]1O[C@@H]1C(O)\C=C/C\C=C/CCCC(O)=O
InChI Identifier
InChI=1S/C20H32O4/c1-2-3-4-5-9-12-15-18-20(24-18)17(21)14-11-8-6-7-10-13-16-19(22)23/h6-7,9,11-12,14,17-18,20-21H,2-5,8,10,13,15-16H2,1H3,(H,22,23)/b7-6-,12-9-,14-11-/t17?,18-,20+/m0/s1
InChI KeyDWNBPRRXEVJMPO-YZTVQBIISA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hepoxilins. These are eicosanoids containing an oxirane group attached to the fatty acyl chain.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassEicosanoids
Direct ParentHepoxilins
Alternative Parents
Substituents
  • Hepoxilin
  • Medium-chain hydroxy acid
  • Medium-chain fatty acid
  • Epoxy fatty acid
  • Heterocyclic fatty acid
  • Hydroxy fatty acid
  • Fatty acid
  • Unsaturated fatty acid
  • Secondary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Dialkyl ether
  • Oxirane
  • Ether
  • Oxacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Hydrocarbon derivative
  • Carbonyl group
  • Alcohol
  • Organic oxygen compound
  • Organooxygen compound
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.0092 g/LALOGPS
logP5.11ALOGPS
logP4.73ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)4.82ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area70.06 ŲChemAxon
Rotatable Bond Count14ChemAxon
Refractivity99.57 m³·mol⁻¹ChemAxon
Polarizability39.72 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+189.70131661259
DarkChem[M-H]-188.19731661259
DeepCCS[M+H]+194.97430932474
DeepCCS[M-H]-192.44330932474
DeepCCS[M-2H]-226.90830932474
DeepCCS[M+Na]+202.13530932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Hepoxilin B3CCCCC\C=C/C[C@@H]1O[C@@H]1C(O)\C=C/C\C=C/CCCC(O)=O3948.1Standard polar33892256
Hepoxilin B3CCCCC\C=C/C[C@@H]1O[C@@H]1C(O)\C=C/C\C=C/CCCC(O)=O2473.2Standard non polar33892256
Hepoxilin B3CCCCC\C=C/C[C@@H]1O[C@@H]1C(O)\C=C/C\C=C/CCCC(O)=O2577.4Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Hepoxilin B3,1TMS,isomer #1CCCCC/C=C\C[C@@H]1O[C@@H]1C(/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C2617.7Semi standard non polar33892256
Hepoxilin B3,1TMS,isomer #2CCCCC/C=C\C[C@@H]1O[C@@H]1C(O)/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C2580.3Semi standard non polar33892256
Hepoxilin B3,2TMS,isomer #1CCCCC/C=C\C[C@@H]1O[C@@H]1C(/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C)O[Si](C)(C)C2617.6Semi standard non polar33892256
Hepoxilin B3,1TBDMS,isomer #1CCCCC/C=C\C[C@@H]1O[C@@H]1C(/C=C\C/C=C\CCCC(=O)O)O[Si](C)(C)C(C)(C)C2833.9Semi standard non polar33892256
Hepoxilin B3,1TBDMS,isomer #2CCCCC/C=C\C[C@@H]1O[C@@H]1C(O)/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C2831.2Semi standard non polar33892256
Hepoxilin B3,2TBDMS,isomer #1CCCCC/C=C\C[C@@H]1O[C@@H]1C(/C=C\C/C=C\CCCC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3098.3Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Hepoxilin B3 GC-MS (Non-derivatized) - 70eV, Positivesplash10-0f89-1900000000-7e176d0aeaf4c4f1ee842017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hepoxilin B3 GC-MS (2 TMS) - 70eV, Positivesplash10-004i-7509200000-646f9e780523dd7060e72017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Hepoxilin B3 GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 10V, Positive-QTOFsplash10-014i-0419000000-8de60f1d7da49d39d6292017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 20V, Positive-QTOFsplash10-0100-2901000000-2b574e8af2bff160c04a2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 40V, Positive-QTOFsplash10-052f-9300000000-171ed87708ea6a95def52017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 10V, Negative-QTOFsplash10-000i-0319000000-57e762a656ee448ceae42017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 20V, Negative-QTOFsplash10-0udi-0902000000-c21e19e865d525b267952017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 40V, Negative-QTOFsplash10-0006-9500000000-683be61d26516deb45002017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 10V, Positive-QTOFsplash10-0gbi-1219000000-bc47eb0a7064bed6f4822021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 20V, Positive-QTOFsplash10-0lel-9546000000-c5d4fbc2b087abf03bdb2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 40V, Positive-QTOFsplash10-016u-9200000000-2828e107370bf277debc2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 10V, Negative-QTOFsplash10-000i-0109000000-8afa53cdece6f268eab62021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 20V, Negative-QTOFsplash10-000i-1915000000-087ec9ceff47ac4d4d802021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Hepoxilin B3 40V, Negative-QTOFsplash10-0006-9430000000-ebabed01fd13ebff372c2021-09-25Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
  • Mitochondria
Biospecimen LocationsNot Available
Tissue Locations
  • Epidermis
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023407
KNApSAcK IDC00000413
Chemspider ID4446330
KEGG Compound IDC14810
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkHepoxilin
METLIN ID7071
PubChem Compound5283209
PDB IDNot Available
ChEBI ID34784
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Anton R, Vila L: Stereoselective biosynthesis of hepoxilin B3 in human epidermis. J Invest Dermatol. 2000 Mar;114(3):554-9. [PubMed:10692117 ]
  2. Anton R, Camacho M, Puig L, Vila L: Hepoxilin B3 and its enzymatically formed derivative trioxilin B3 are incorporated into phospholipids in psoriatic lesions. J Invest Dermatol. 2002 Jan;118(1):139-46. [PubMed:11851887 ]
  3. Pace-Asciak CR, Reynaud D, Demin P, Nigam S: The hepoxilins. A review. Adv Exp Med Biol. 1999;447:123-32. [PubMed:10086189 ]