Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2006-10-17 09:06:20 UTC |
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Update Date | 2022-03-07 02:49:25 UTC |
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HMDB ID | HMDB0005022 |
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Secondary Accession Numbers | - HMDB0014321
- HMDB05022
- HMDB14321
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Metabolite Identification |
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Common Name | Pravastatin |
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Description | Pravastatin is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Pravastatin was identified originally in a mold called Nocardia autotrophica by researchers of the Sankyo Pharma Inc; An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (hydroxymethylglutaryl CoA reductases); In medicine and pharmacology, pravastatin (Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. |
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Structure | [H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1 |
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Synonyms | Value | Source |
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(+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid | ChEBI | Pravastatin acid | ChEBI | Pravastatina | ChEBI | Pravastatine | ChEBI | Pravastatinum | ChEBI | Pravator | Kegg | (+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoate | Generator | (3R,5R)-7-[(1S,2S,6S,8S,8AR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid | HMDB | 3beta-Hydroxycompactin | HMDB | Eptastatin | HMDB | Mevalothin | HMDB | Pravachol | HMDB | Pravastatin sodium | HMDB | Selektine | HMDB | Elisor | HMDB | Nu-pravastatin | HMDB | Pravasin | HMDB | Apo pravastatin | HMDB | Aventis brand OF pravastatin sodium | HMDB | Bristol-myers squibb brand OF pravastatin sodium | HMDB | Juste brand OF pravastatin sodium | HMDB | Lin pravastatin | HMDB | Mevalotin | HMDB | Pravastatin monosodium salt, (6 beta)-isomer | HMDB | Pravastatin sodium salt | HMDB | Pravastatin, (6 beta)-isomer | HMDB | RMS-431 | HMDB | Squibb brand OF pravastatin sodium | HMDB | Vasten | HMDB | Apo-pravastatin | HMDB | Apotex brand OF pravastatin sodium | HMDB | Linson pharma brand OF pravastatin sodium | HMDB | Liplat | HMDB | Lipostat | HMDB | Nu-pharma brand OF pravastatin sodium | HMDB | Prareduct | HMDB | Pravastatin tert-octylamine salt | HMDB | RMS 431 | HMDB | Sankyo brand OF pravastatin sodium | HMDB | Sodium salt, pravastatin | HMDB | Bristacol | HMDB | Esteve brand OF pravastatin sodium | HMDB | Lin-pravastatin | HMDB | Lipemol | HMDB | Nu pravastatin | HMDB | Pravacol | HMDB | Pravastatin tert octylamine salt | HMDB |
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Chemical Formula | C23H36O7 |
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Average Molecular Weight | 424.5277 |
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Monoisotopic Molecular Weight | 424.246103506 |
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IUPAC Name | (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid |
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Traditional Name | pravastatin |
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CAS Registry Number | 81093-37-0 |
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SMILES | [H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC |
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InChI Identifier | InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1 |
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InChI Key | TUZYXOIXSAXUGO-PZAWKZKUSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as medium-chain hydroxy acids and derivatives. These are hydroxy acids with a 6 to 12 carbon atoms long side chain. |
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Kingdom | Organic compounds |
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Super Class | Organic acids and derivatives |
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Class | Hydroxy acids and derivatives |
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Sub Class | Medium-chain hydroxy acids and derivatives |
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Direct Parent | Medium-chain hydroxy acids and derivatives |
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Alternative Parents | |
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Substituents | - Medium-chain hydroxy acid
- Fatty alcohol
- Medium-chain fatty acid
- Hydroxy fatty acid
- Fatty acid ester
- Branched fatty acid
- Beta-hydroxy acid
- Fatty acyl
- Dicarboxylic acid or derivatives
- Secondary alcohol
- Carboxylic acid ester
- Carboxylic acid
- Carboxylic acid derivative
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Alcohol
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | |
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Ontology |
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Disposition
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Biological location
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 326 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 0.24 g/L | Not Available | LogP | 2.2 | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredictor | Adduct Type | CCS Value (Å2) | Reference |
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DarkChem | [M+H]+ | 198.503 | 31661259 | DarkChem | [M-H]- | 197.275 | 31661259 | DeepCCS | [M-2H]- | 241.179 | 30932474 | DeepCCS | [M+Na]+ | 216.027 | 30932474 |
Predicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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Pravastatin,1TMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@H]21 | 3177.6 | Semi standard non polar | 33892256 | Pravastatin,1TMS,isomer #2 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O)O[Si](C)(C)C)[C@H]21 | 3188.4 | Semi standard non polar | 33892256 | Pravastatin,1TMS,isomer #3 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O)O[Si](C)(C)C)[C@H]21 | 3159.8 | Semi standard non polar | 33892256 | Pravastatin,1TMS,isomer #4 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O[Si](C)(C)C)[C@H]21 | 3202.4 | Semi standard non polar | 33892256 | Pravastatin,2TMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O)O[Si](C)(C)C)[C@H]21 | 3210.0 | Semi standard non polar | 33892256 | Pravastatin,2TMS,isomer #2 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O)O[Si](C)(C)C)[C@H]21 | 3188.9 | Semi standard non polar | 33892256 | Pravastatin,2TMS,isomer #3 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O[Si](C)(C)C)[C@H]21 | 3212.3 | Semi standard non polar | 33892256 | Pravastatin,2TMS,isomer #4 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3179.7 | Semi standard non polar | 33892256 | Pravastatin,2TMS,isomer #5 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3207.2 | Semi standard non polar | 33892256 | Pravastatin,2TMS,isomer #6 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3187.4 | Semi standard non polar | 33892256 | Pravastatin,3TMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3214.3 | Semi standard non polar | 33892256 | Pravastatin,3TMS,isomer #2 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3229.4 | Semi standard non polar | 33892256 | Pravastatin,3TMS,isomer #3 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3216.7 | Semi standard non polar | 33892256 | Pravastatin,3TMS,isomer #4 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3196.6 | Semi standard non polar | 33892256 | Pravastatin,4TMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C)[C@H]21 | 3240.9 | Semi standard non polar | 33892256 | Pravastatin,1TBDMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@H]21 | 3414.9 | Semi standard non polar | 33892256 | Pravastatin,1TBDMS,isomer #2 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3447.2 | Semi standard non polar | 33892256 | Pravastatin,1TBDMS,isomer #3 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3408.8 | Semi standard non polar | 33892256 | Pravastatin,1TBDMS,isomer #4 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3467.1 | Semi standard non polar | 33892256 | Pravastatin,2TBDMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3662.8 | Semi standard non polar | 33892256 | Pravastatin,2TBDMS,isomer #2 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3640.0 | Semi standard non polar | 33892256 | Pravastatin,2TBDMS,isomer #3 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3672.6 | Semi standard non polar | 33892256 | Pravastatin,2TBDMS,isomer #4 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3652.5 | Semi standard non polar | 33892256 | Pravastatin,2TBDMS,isomer #5 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3692.8 | Semi standard non polar | 33892256 | Pravastatin,2TBDMS,isomer #6 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3672.3 | Semi standard non polar | 33892256 | Pravastatin,3TBDMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3871.4 | Semi standard non polar | 33892256 | Pravastatin,3TBDMS,isomer #2 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@@H](O)CC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3890.1 | Semi standard non polar | 33892256 | Pravastatin,3TBDMS,isomer #3 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3877.8 | Semi standard non polar | 33892256 | Pravastatin,3TBDMS,isomer #4 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 3885.0 | Semi standard non polar | 33892256 | Pravastatin,4TBDMS,isomer #1 | CC[C@H](C)C(=O)O[C@H]1C[C@H](O[Si](C)(C)C(C)(C)C)C=C2C=C[C@H](C)[C@H](CC[C@H](C[C@H](CC(=O)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)[C@H]21 | 4074.5 | Semi standard non polar | 33892256 |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - Pravastatin GC-MS (Non-derivatized) - 70eV, Positive | splash10-0a4i-6194400000-5f7280491acf9312a516 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Pravastatin GC-MS (3 TMS) - 70eV, Positive | splash10-004i-8202269000-c5995d4b5b537e3a6f6e | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Pravastatin GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0uk9-0009000000-967b377abafe64b73071 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-00di-0002900000-bd7fd66d793ae64426ff | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-4809000000-0ed5a8797dfc49ecf5af | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-2900000000-91b125182ce5d90f16ab | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-1900000000-e8fc6384260de93c5aa8 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-1900000000-11e99968bc0ba393b6f9 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-4900000000-0e4265e6dc1468c1471d | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-00di-0002900000-8795ee00dded0ef8be48 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-3709000000-aa45be15af0471c0a46e | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-2900000000-5617409991f5c58e5130 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-2900000000-2bf5c13979a639625d1c | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-2900000000-9a233e521607e82ab7a0 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0udi-0900000000-2083dfbb67bf2b03ccf9 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-ITFT , negative-QTOF | splash10-0uk9-0009000000-4b2c09a295ba7f3ce41b | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin LC-ESI-QFT , negative-QTOF | splash10-00di-0607900000-e57e263ad3f74bfda195 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin 35V, Negative-QTOF | splash10-0uk9-0209000000-e1f3357e6db2a045c733 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin 35V, Positive-QTOF | splash10-053r-0890100000-343e9a2af9d9e56f3078 | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin 15V, Negative-QTOF | splash10-0fk9-3209000000-4e7af37985a2d2fdf90c | 2021-09-20 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Pravastatin 30V, Negative-QTOF | splash10-0pb9-9600000000-1e8b86b20daa312fd4c0 | 2021-09-20 | HMDB team, MONA | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Pravastatin 10V, Positive-QTOF | splash10-052r-1009600000-9928021021dc6868847d | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Pravastatin 20V, Positive-QTOF | splash10-052r-4019100000-bea6aa9fed446c2cdd3c | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Pravastatin 40V, Positive-QTOF | splash10-052r-9023000000-7b0213c49b76e864814e | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Pravastatin 10V, Negative-QTOF | splash10-05fr-1007900000-cb1ad55355bd717f1c23 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Pravastatin 20V, Negative-QTOF | splash10-0a4i-5209300000-f017d063b98b59e6d5f1 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Pravastatin 40V, Negative-QTOF | splash10-0a4i-9244000000-d95d5ae750ad620ba728 | 2016-08-03 | Wishart Lab | View Spectrum |
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General References | - Pokrovskaia EV, Vaulin NA, Gratsianskii NA, Averkov OV, Deev AD: [Markers of inflammation and platelet aggregation in patients with non ST elevation acute coronary syndrome treated with atorvastatin or pravastatin]. Kardiologiia. 2003;43(1):7-18. [PubMed:12891281 ]
- Tonelli M, Sacks F, Pfeffer M, Jhangri GS, Curhan G: Biomarkers of inflammation and progression of chronic kidney disease. Kidney Int. 2005 Jul;68(1):237-45. [PubMed:15954913 ]
- Peverill RE, Smolich JJ, Malan E, Goldstat R, Davis SR: Comparison of effects of pravastatin and hormone therapy on soluble P-selectin and platelet P-selectin expression in postmenopausal hypercholesterolemic women. Maturitas. 2006 Jan 20;53(2):158-65. [PubMed:16368469 ]
- Gaugler MH, Vereycken-Holler V, Squiban C, Vandamme M, Vozenin-Brotons MC, Benderitter M: Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses. Radiat Res. 2005 May;163(5):479-87. [PubMed:15850408 ]
- Bruni F, Puccetti L, Pasqui AL, Pastorelli M, Bova G, Cercignani M, Palazzuoli A, Leo A, Auteri A: Different effect induced by treatment with several statins on monocyte tissue factor expression in hypercholesterolemic subjects. Clin Exp Med. 2003 May;3(1):45-53. [PubMed:12748879 ]
- Tonelli M, Isles C, Craven T, Tonkin A, Pfeffer MA, Shepherd J, Sacks FM, Furberg C, Cobbe SM, Simes J, West M, Packard C, Curhan GC: Effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease. Circulation. 2005 Jul 12;112(2):171-8. Epub 2005 Jul 5. [PubMed:15998677 ]
- (). FDA label . .
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