Record Information |
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Version | 4.0 |
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Status | Expected but not Quantified |
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Creation Date | 2007-05-22 20:52:31 UTC |
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Update Date | 2020-03-06 18:54:40 UTC |
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HMDB ID | HMDB0006273 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid |
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Description | 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid, also known as 1-(5'-phosphoribosyl)-4-carboxy-5-aminoimidazole or 1-(5-phospho-D-ribosyl)-5-amino-4-imidazolecarboxylic acid, belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid is a very strong basic compound (based on its pKa). 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid exists in all living species, ranging from bacteria to humans. Within humans, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid participates in a number of enzymatic reactions. In particular, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid can be converted into 5-aminoimidazole ribonucleotide; which is mediated by the enzyme multifunctional protein ADE2. In addition, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid and L-aspartic acid can be converted into SAICAR; which is mediated by the enzyme multifunctional protein ADE2. In humans, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid is involved in the metabolic disorder called Lesch-Nyhan syndrome (LNS). Outside of the human body, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid has been detected, but not quantified in, several different foods, such as ohelo berries, Chinese mustards, peach (var.), jackfruits, and saskatoon berries. This could make 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid a potential biomarker for the consumption of these foods. 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid is an intermediate in purine metabolism. 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid is converted from aminoimidazole ribotide via phosphoribosylaminoimidazole carboxylase (EC: 4.1.1.21). |
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Structure | |
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Synonyms | Value | Source |
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1-(5'-Phosphoribosyl)-4-carboxy-5-aminoimidazole | ChEBI | 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole | ChEBI | 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxylate | ChEBI | 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate | ChEBI | 5'-Phosphoribosyl-4-carboxy-5-aminoimidazole | ChEBI | 5'-Phosphoribosyl-5-amino-4-imidazolecarboxylate | ChEBI | 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxylic acid | Generator | 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylic acid | Generator | 5'-Phosphoribosyl-5-amino-4-imidazolecarboxylic acid | Generator | 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylic acid | Generator | 4-Carboxy-5-aminoimidazole ribonucleotide | HMDB | 5'Phosphoribosyl-4-carboxy-5-aminoimidazole | HMDB | 5-Amino-4-carboxyimidazole ribonucleotide | HMDB | 5-Amino-4-imidazolecarboxylic acid ribonucleotide | HMDB | 5-Aminoimidazole carboxilic acid ribonucleotice | HMDB | 5-Aminoimidazole-4-carboxilic acid ribonucleotide | HMDB | Carboxyaminoimidazole ribonucleotide | HMDB | Carboxy-air | HMDB | AICOR | HMDB | Carboxyaminoimidazole ribotide | MeSH | CAIR | MeSH | 5-Amino-1-(5-O-phosphonopentofuranosyl)-1H-imidazole-4-carboxylic acid | MeSH | 1-(5’-Phosphoribosyl)-4-carboxy-5-aminoimidazole | HMDB | 1-(5’-Phosphoribosyl)-5-amino-4-carboxyimidazole | HMDB | 1-(5’-Phosphoribosyl)-5-amino-4-imidazolecarboxylate | HMDB | 5-Amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid | HMDB | 5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid | HMDB | 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate | HMDB | 5-Aminoimidazole 4-carboxylic acid ribonucleotide | HMDB | 5-Aminoimidazolecarboxylic acid ribonucleotide | HMDB | 5’-Phosphoribosyl-4-carboxy-5-aminoimidazole | HMDB | 5’-Phosphoribosyl-5-amino-4-imidazolecarboxylate | HMDB |
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Chemical Formula | C9H14N3O9P |
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Average Molecular Weight | 339.1959 |
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Monoisotopic Molecular Weight | 339.046765573 |
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IUPAC Name | 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazole-4-carboxylic acid |
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Traditional Name | 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]imidazole-4-carboxylic acid |
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CAS Registry Number | 6001-14-5 |
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SMILES | NC1=C(N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(O)=O |
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InChI Identifier | InChI=1S/C9H14N3O9P/c10-7-4(9(15)16)11-2-12(7)8-6(14)5(13)3(21-8)1-20-22(17,18)19/h2-3,5-6,8,13-14H,1,10H2,(H,15,16)(H2,17,18,19)/t3-,5-,6-,8-/m1/s1 |
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InChI Key | XFVULMDJZXYMSG-ZIYNGMLESA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as pentose phosphates. These are carbohydrate derivatives containing a pentose substituted by one or more phosphate groups. |
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Kingdom | Organic compounds |
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Super Class | Organic oxygen compounds |
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Class | Organooxygen compounds |
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Sub Class | Carbohydrates and carbohydrate conjugates |
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Direct Parent | Pentose phosphates |
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Alternative Parents | |
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Substituents | - Pentose phosphate
- Pentose-5-phosphate
- Imidazole ribonucleoside
- N-glycosyl compound
- Glycosyl compound
- Monosaccharide phosphate
- Monoalkyl phosphate
- Imidazole-4-carbonyl group
- Alkyl phosphate
- Phosphoric acid ester
- Aminoimidazole
- Organic phosphoric acid derivative
- N-substituted imidazole
- Azole
- Vinylogous amide
- Tetrahydrofuran
- Imidazole
- Heteroaromatic compound
- 1,2-diol
- Secondary alcohol
- Amino acid
- Amino acid or derivatives
- Oxacycle
- Carboxylic acid derivative
- Carboxylic acid
- Azacycle
- Organoheterocyclic compound
- Monocarboxylic acid or derivatives
- Alcohol
- Organic nitrogen compound
- Hydrocarbon derivative
- Amine
- Organopnictogen compound
- Organic oxide
- Primary amine
- Organonitrogen compound
- Aromatic heteromonocyclic compound
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Molecular Framework | Aromatic heteromonocyclic compounds |
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External Descriptors | |
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Ontology |
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Disposition | Route of exposure: Source: Biological location: |
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Process | Naturally occurring process: |
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Physical Properties |
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State | Solid |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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| Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-0002-9613000000-2a087bcb710ee7b50b52 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positive | splash10-00lu-2923230000-25e41df497cf1b5c9281 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-0914000000-87d6bac417ced888900f | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-01t9-1900000000-e298883e772e11c253f0 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-004i-8900000000-82583bffa17f1262d918 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004r-8928000000-d296c2812c7b06149794 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-9400000000-76793052d8d2699d70dd | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-004i-9000000000-a8b367167e97f6df3690 | Spectrum |
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