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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2008-09-16 08:31:36 UTC
Update Date2021-09-14 15:40:22 UTC
HMDB IDHMDB0010358
Secondary Accession Numbers
  • HMDB10358
Metabolite Identification
Common Name17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide)
Description17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) is a natural human metabolite of 17beta-estradiol 3-sulfate generated in the liver by UDP glucuonyltransferase. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
Structure
Data?1582752819
Synonyms
ValueSource
Estradiol 17beta-glucuronide 3-sulfateKegg
Estradiol 17b-glucuronide 3-sulfateGenerator
Estradiol 17b-glucuronide 3-sulfuric acidGenerator
Estradiol 17b-glucuronide 3-sulphateGenerator
Estradiol 17b-glucuronide 3-sulphuric acidGenerator
Estradiol 17beta-glucuronide 3-sulfuric acidGenerator
Estradiol 17beta-glucuronide 3-sulphateGenerator
Estradiol 17beta-glucuronide 3-sulphuric acidGenerator
Estradiol 17β-glucuronide 3-sulfateGenerator
Estradiol 17β-glucuronide 3-sulfuric acidGenerator
Estradiol 17β-glucuronide 3-sulphateGenerator
Estradiol 17β-glucuronide 3-sulphuric acidGenerator
17-b-Estradiol 3-sulfate-17-(b-D-glucuronide)Generator
17-b-Estradiol 3-sulfuric acid-17-(b-D-glucuronide)Generator
17-b-Estradiol 3-sulphate-17-(b-D-glucuronide)Generator
17-b-Estradiol 3-sulphuric acid-17-(b-D-glucuronide)Generator
17-beta-Estradiol 3-sulfuric acid-17-(beta-D-glucuronide)Generator
17-beta-Estradiol 3-sulphate-17-(beta-D-glucuronide)Generator
17-beta-Estradiol 3-sulphuric acid-17-(beta-D-glucuronide)Generator
17-Β-estradiol 3-sulfate-17-(β-D-glucuronide)Generator
17-Β-estradiol 3-sulfuric acid-17-(β-D-glucuronide)Generator
17-Β-estradiol 3-sulphate-17-(β-D-glucuronide)Generator
17-Β-estradiol 3-sulphuric acid-17-(β-D-glucuronide)Generator
17beta-Estradiol 3-sulfate-17-(beta-D-glucuronoside)HMDB
17beta-Estradiol 3-sulfate-17-(beta-delta-glucuronoside)HMDB
17beta-Estradiol 3-sulphate-17-(beta-D-glucuronoside)HMDB
17beta-Estradiol 3-sulphate-17-(beta-delta-glucuronoside)HMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulfate-17-D-glucuronideHMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulfate-17-D-glucuronosideHMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulfate-17-delta-glucuronideHMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulfate-17-delta-glucuronosideHMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulphate-17-D-glucuronideHMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulphate-17-D-glucuronosideHMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulphate-17-delta-glucuronideHMDB
Estra-1,3,5(10)-triene-3,17beta-diol 3-sulphate-17-delta-glucuronosideHMDB
Chemical FormulaC24H32O11S
Average Molecular Weight528.569
Monoisotopic Molecular Weight528.166532556
IUPAC Name(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-{[(1S,10R,11S,14S,15S)-15-methyl-5-(sulfooxy)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-trien-14-yl]oxy}oxane-2-carboxylic acid
Traditional Name(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-{[(1S,10R,11S,14S,15S)-15-methyl-5-(sulfooxy)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-trien-14-yl]oxy}oxane-2-carboxylic acid
CAS Registry NumberNot Available
SMILES
[H][C@@]12CC[C@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(OS(O)(=O)=O)C=C3
InChI Identifier
InChI=1S/C24H32O11S/c1-24-9-8-14-13-5-3-12(35-36(30,31)32)10-11(13)2-4-15(14)16(24)6-7-17(24)33-23-20(27)18(25)19(26)21(34-23)22(28)29/h3,5,10,14-21,23,25-27H,2,4,6-9H2,1H3,(H,28,29)(H,30,31,32)/t14-,15-,16+,17+,18+,19+,20-,21+,23-,24+/m1/s1
InChI KeyVRMSCBRLZUCJBX-QXYWQCSFSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as steroidal glycosides. These are sterol lipids containing a carbohydrate moiety glycosidically linked to the steroid skeleton.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassSteroidal glycosides
Direct ParentSteroidal glycosides
Alternative Parents
Substituents
  • Steroidal glycoside
  • Sulfated steroid skeleton
  • Estrane-skeleton
  • 1-o-glucuronide
  • O-glucuronide
  • Phenanthrene
  • Glucuronic acid or derivatives
  • Glycosyl compound
  • O-glycosyl compound
  • Arylsulfate
  • Tetralin
  • Beta-hydroxy acid
  • Sulfate-ester
  • Sulfuric acid monoester
  • Hydroxy acid
  • Monosaccharide
  • Oxane
  • Benzenoid
  • Pyran
  • Sulfuric acid ester
  • Organic sulfuric acid or derivatives
  • Secondary alcohol
  • Organoheterocyclic compound
  • Oxacycle
  • Monocarboxylic acid or derivatives
  • Acetal
  • Carboxylic acid derivative
  • Polyol
  • Carboxylic acid
  • Hydrocarbon derivative
  • Alcohol
  • Organic oxide
  • Organooxygen compound
  • Carbonyl group
  • Organic oxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility1.25 g/LALOGPS
logP0.25ALOGPS
logP0.16ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)-1.7ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area180.05 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity122.18 m³·mol⁻¹ChemAxon
Polarizability53.25 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M-2H]-255.65830932474
DeepCCS[M+Na]+229.67830932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide)[H][C@@]12CC[C@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(OS(O)(=O)=O)C=C35336.1Standard polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide)[H][C@@]12CC[C@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(OS(O)(=O)=O)C=C34087.2Standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide)[H][C@@]12CC[C@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(OS(O)(=O)=O)C=C34362.4Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TMS,isomer #1C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O4293.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TMS,isomer #2C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O4273.0Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TMS,isomer #3C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C4275.6Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TMS,isomer #4C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@H]1O4252.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TMS,isomer #5C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O4306.1Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #1C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O4226.4Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #10C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@H]1O4214.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #2C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O4210.6Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #3C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O[Si](C)(C)C4216.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #4C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O4248.1Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #5C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O4198.1Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #6C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4218.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #7C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O4245.2Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #8C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C4204.7Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TMS,isomer #9C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C4243.9Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #1C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O4187.3Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #10C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O)[C@H]1O[Si](C)(C)C4184.7Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #2C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O[Si](C)(C)C4204.4Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #3C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O4195.9Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #4C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4188.1Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #5C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O4187.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #6C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O[Si](C)(C)C4186.3Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #7C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4185.1Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #8C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O4168.2Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TMS,isomer #9C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4189.7Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),4TMS,isomer #1C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4190.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),4TMS,isomer #2C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O4160.0Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),4TMS,isomer #3C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)[C@H]1O[Si](C)(C)C4175.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),4TMS,isomer #4C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4186.9Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),4TMS,isomer #5C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4166.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),5TMS,isomer #1C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4170.2Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),5TMS,isomer #1C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4689.7Standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),5TMS,isomer #1C[C@]12CC[C@@H]3C4=CC=C(OS(=O)(=O)O[Si](C)(C)C)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O[C@@H]1O[C@H](C(=O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)[C@H]1O[Si](C)(C)C4988.5Standard polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@H]1O4543.3Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@H]1[C@H](O)[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@@H]1O4532.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](O)[C@H](O)[C@@H](C(=O)O)O[C@H]1O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(OS(=O)(=O)O)=CC=C4[C@H]3CC[C@]12C4527.9Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@@H](O)[C@@H]1O4544.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),1TBDMS,isomer #5CC(C)(C)[Si](C)(C)OS(=O)(=O)OC1=CC=C2C(=C1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O[C@@H]3O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]3O)CC[C@@H]124547.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C4753.4Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@@H](O)[C@@H]1O4721.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1O4709.4Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@H]1O[Si](C)(C)C(C)(C)C4704.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@H]1O4717.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #5CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O4715.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #6CC(C)(C)[Si](C)(C)O[C@H]1[C@H](O)[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@@H]1O[Si](C)(C)C(C)(C)C4704.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #7CC(C)(C)[Si](C)(C)O[C@H]1[C@H](O)[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@@H]1O4707.9Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@H]1O4734.3Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),2TBDMS,isomer #9CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](O)[C@H](O)[C@@H](C(=O)O)O[C@H]1O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C4[C@H]3CC[C@]12C4714.2Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C4924.1Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)[C@@H]1O4895.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C4897.9Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C4898.8Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@H]1[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@@H]1O[Si](C)(C)C(C)(C)C4887.7Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1O4862.5Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #6CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@H]1O[Si](C)(C)C(C)(C)C4860.2Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O)=CC=C5[C@H]4CC[C@]23C)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O4890.4Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC(=O)[C@H]1O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@H](O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O4872.4Semi standard non polar33892256
17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide),3TBDMS,isomer #9CC(C)(C)[Si](C)(C)O[C@H]1[C@H](O)[C@@H](C(=O)O)O[C@@H](O[C@H]2CC[C@H]3[C@@H]4CCC5=CC(OS(=O)(=O)O[Si](C)(C)C(C)(C)C)=CC=C5[C@H]4CC[C@]23C)[C@@H]1O[Si](C)(C)C(C)(C)C4856.0Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (Non-derivatized) - 70eV, Positivesplash10-08g0-9234530000-794a38cf6deeb6afbd522017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (2 TMS) - 70eV, Positivesplash10-0a4i-8412309000-c5ab003947f67cb973302017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_1_5) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_7) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_8) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_9) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_2_10) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_1) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_2) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_3) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_4) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_5) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_6) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_7) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_8) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) GC-MS (TMS_3_9) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 10V, Positive-QTOFsplash10-0w4r-0009050000-5601df8bc7f07ad14fd22016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 20V, Positive-QTOFsplash10-0fe0-0169100000-09722aedf482d927b5412016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 40V, Positive-QTOFsplash10-0udi-0294000000-b88534d43f6874ba0c1d2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 10V, Negative-QTOFsplash10-0fc0-2209480000-eaa3f47f2352e9eec58a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 20V, Negative-QTOFsplash10-0udi-2349410000-281bd31fd6daa5410d9a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 40V, Negative-QTOFsplash10-0uyi-9158000000-ccf753ef8ba87f33c5722016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 10V, Negative-QTOFsplash10-004i-0000090000-89ae18b1c96c30af86892021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 20V, Negative-QTOFsplash10-056s-9707450000-80b12d813f5d355f02a82021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 40V, Negative-QTOFsplash10-11bi-9008000000-adcbd77a2a425b3f13ad2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 10V, Positive-QTOFsplash10-0m0i-0339270000-99b84165a512e8c28fe82021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 20V, Positive-QTOFsplash10-000i-0296120000-90210b8933e57b0996fe2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) 40V, Positive-QTOFsplash10-000i-0796000000-f0ba8e6b0750ab5bc45d2021-09-22Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue Locations
  • Kidney
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableNormal
      Not Available
details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableNormal
      Not Available
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB027510
KNApSAcK IDNot Available
Chemspider ID4445182
KEGG Compound IDC11289
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound5281895
PDB IDNot Available
ChEBI ID792
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
Gene Name:
UGT2B4
Uniprot ID:
P06133
Molecular weight:
60512.035
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.
Gene Name:
UGT1A4
Uniprot ID:
P22310
Molecular weight:
60024.535
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol (in vitro).
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular weight:
60720.15
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular weight:
59590.91
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
Gene Name:
UGT1A9
Uniprot ID:
O60656
Molecular weight:
59940.495
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
Gene Name:
UGT1A6
Uniprot ID:
P19224
Molecular weight:
60750.215
General function:
Involved in transferase activity, transferring hexosyl groups
Specific function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Gene Name:
UGT2B11
Uniprot ID:
O75310
Molecular weight:
61037.8
General function:
Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
Specific function:
Plays an important role in the degradation of dermatan and keratan sulfates.
Gene Name:
GUSB
Uniprot ID:
P08236
Molecular weight:
74731.46