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Record Information
Version4.0
StatusExpected but not Quantified
Creation Date2008-10-16 22:28:01 UTC
Update Date2020-06-26 02:34:23 UTC
HMDB IDHMDB0011110
Secondary Accession Numbers
  • HMDB11110
Metabolite Identification
Common NameHydrogen selenide
DescriptionHydrogen selenide, also known as selenide, belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. Hydrogen selenide is a drug. Hydrogen selenide is possibly neutral. Hydrogen selenide exists in all living organisms, ranging from bacteria to humans. According to the Sonoda method, H2Se is generated from the reaction of H2O and CO on Se in the presence of Et3N. Within humans, hydrogen selenide participates in a number of enzymatic reactions. In particular, L-alanine and hydrogen selenide can be biosynthesized from selenocysteine; which is mediated by the enzyme selenocysteine lyase. In addition, hydrogen selenide can be converted into phosphoroselenoic acid; which is mediated by the enzyme selenide, water dikinase 2. In humans, hydrogen selenide is involved in selenoamino acid metabolism. Hydrogen selenide is a potentially toxic compound. Even at extremely low concentrations, this compound has a very irritating smell resembling that of decayed horseradish or 'leaking gas', but smells of rotten eggs at higher concentrations. H2Se is a colorless, flammable gas under standard conditions. H2Se + SO2 ⇌ 2 H2O + 2 Se + SIts decomposition is used to prepare the highly pure element.
Structure
Data?1593138863
Synonyms
ValueSource
SelenideKegg
[SeH2]ChEBI
H2SeChEBI
Hydroselenic acidChEBI
HydroselenateGenerator
Dihydrogen monoselenideHMDB
Dihydrogen selenideHMDB
SelaneHMDB, MeSH
Selenium dihydrideHMDB
Selenium hydrideHMDB
Selenium hydride (seh2)HMDB
Hydrogen selenide, 75Se-labeledMeSH
Chemical FormulaH2Se
Average Molecular Weight80.98
Monoisotopic Molecular Weight81.932171892
IUPAC Namehydrogen selenide
Traditional Namehydrogen selenide
CAS Registry Number7783-07-5
SMILES
[SeH2]
InChI Identifier
InChI=1S/H2Se/h1H2
InChI KeySPVXKVOXSXTJOY-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative Parents
Substituents
  • Homogeneous other non metal
  • Inorganic selenide
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Process

Naturally occurring process:

Role

Environmental role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.5ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity14.71 m³·mol⁻¹ChemAxon
Polarizability2.81 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-9000000000-d9ac578ecd68e91829fbSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-9000000000-d9ac578ecd68e91829fbSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-9000000000-d9ac578ecd68e91829fbSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-9000000000-b0759ba90e57e47d8446Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-9000000000-b0759ba90e57e47d8446Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-9000000000-b0759ba90e57e47d8446Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDBMET01458
Phenol Explorer Compound IDNot Available
FooDB IDFDB027892
KNApSAcK IDNot Available
Chemspider ID518
KEGG Compound IDC01528
BioCyc IDCPD-678
BiGG IDNot Available
Wikipedia LinkHydrogen selenide
METLIN IDNot Available
PubChem Compound533
PDB IDSE
ChEBI ID16503
Food Biomarker OntologyNot Available
VMH IDSELN
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Sayato Y, Nakamuro K, Hasegawa T: [Selenium methylation and toxicity mechanism of selenocystine]. Yakugaku Zasshi. 1997 Nov;117(10-11):665-72. [PubMed:9414580 ]
  2. Lu J, Jiang C: Antiangiogenic activity of selenium in cancer chemoprevention: metabolite-specific effects. Nutr Cancer. 2001;40(1):64-73. [PubMed:11799926 ]

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Gene Name:
TXNRD1
Uniprot ID:
Q16881
Molecular weight:
70905.58
Reactions
Hydrogen selenide + NADP + Water → Selenite + NADPH + Hydrogen Iondetails
General function:
Involved in oxidoreductase activity
Specific function:
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Gene Name:
TXNRD2
Uniprot ID:
Q9NNW7
Molecular weight:
56506.275
Reactions
Hydrogen selenide + NADP + Water → Selenite + NADPH + Hydrogen Iondetails
General function:
Involved in catalytic activity
Specific function:
Synthesizes selenophosphate from selenide and ATP.
Gene Name:
SEPHS1
Uniprot ID:
P49903
Molecular weight:
42910.325
Reactions
Adenosine triphosphate + Hydrogen selenide + Water → Adenosine monophosphate + Phosphoroselenoic acid + Phosphatedetails
General function:
Involved in catalytic activity
Specific function:
Synthesizes selenophosphate from selenide and ATP.
Gene Name:
SEPHS2
Uniprot ID:
Q99611
Molecular weight:
47304.695
Reactions
Adenosine triphosphate + Hydrogen selenide + Water → Adenosine monophosphate + Phosphoroselenoic acid + Phosphatedetails
General function:
Involved in metabolic process
Specific function:
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity).
Gene Name:
SCLY
Uniprot ID:
Q96I15
Molecular weight:
48793.15
Reactions
Selenocysteine + reduced acceptor → Hydrogen selenide + L-Alanine + acceptordetails
Selenocysteine + Reduced acceptor → Hydrogen selenide + L-Alanine + Acceptordetails
General function:
Involved in oxidoreductase activity
Specific function:
Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).
Gene Name:
TXNRD3
Uniprot ID:
Q86VQ6
Molecular weight:
66600.92
Reactions
Hydrogen selenide + NADP + Water → Selenite + NADPH + Hydrogen Iondetails