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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2009-01-08 17:23:42 UTC
Update Date2022-03-07 02:51:10 UTC
HMDB IDHMDB0011511
Secondary Accession Numbers
  • HMDB11511
Metabolite Identification
Common NameLysoPE(20:0/0:0)
DescriptionLysoPE(20:0/0:0) is a lysophosphatidylethanolamine or a lysophospholipid. The term 'lysophospholipid' (LPL) refers to any phospholipid that is missing one of its two O-acyl chains. Thus, LPLs have a free alcohol in either the sn-1 or sn-2 position. The prefix 'lyso-' comes from the fact that lysophospholipids were originally found to be hemolytic however it is now used to refer generally to phospholipids missing an acyl chain. LPLs are usually the result of phospholipase A-type enzymatic activity on regular phospholipids such as phosphatidylcholine or phosphatidic acid, although they can also be generated by the acylation of glycerophospholipids or the phosphorylation of monoacylglycerols. Some LPLs serve important signaling functions such as lysophosphatidic acid. Lysophosphatidylethanolamines (LPEs) can function as plant growth regulators with several diverse uses. (LPEs) are approved for outdoor agricultural use to accelerate ripening and improve the quality of fresh produce. They are also approved for indoor use to preserve stored crops and commercial cut flowers. As a breakdown product of phosphatidylethanolamine (PE), LPE is present in cells of all organisms.
Structure
Data?1582752915
Synonyms
ValueSource
1-Arachidonyl-2-hydroxy-sn-glycero-3-phosphoethanolamineChEBI
1-Arachidoyl-sn-glycero-3-phosphoethanolamineChEBI
1-Eicosanoyl-glycero-3-phosphoethanolamineChEBI
1-Eicosanoyl-sn-glycero-3-phosphoethanolamineChEBI
Eicosanoyl-lysophosphatidylethanolamineChEBI
LPE(20:0)ChEBI
LPE(20:0/0:0)ChEBI
Lyso-pe(20:0)ChEBI
Lyso-pe(20:0/0:0)ChEBI
LysoPE(20:0)ChEBI
Lysophosphatidylethanolamine(20:0)ChEBI
Lysophosphatidylethanolamine(20:0/0:0)ChEBI
PE(20:0/0:0)ChEBI
1-Eicosanoyl-2-hydroxy-sn-glycero-3-phosphoethanolamineHMDB
LysoPE(20:0/0:0)Lipid Annotator
1-ArachidoylglycerophosphoethanolamineHMDB
1-EicosanoylglycerophosphoethanolamineHMDB
Chemical FormulaC25H52NO7P
Average Molecular Weight509.6566
Monoisotopic Molecular Weight509.348139535
IUPAC Name(2-aminoethoxy)[(2R)-2-hydroxy-3-(icosanoyloxy)propoxy]phosphinic acid
Traditional Name2-aminoethoxy((2R)-2-hydroxy-3-(icosanoyloxy)propoxy)phosphinic acid
CAS Registry Number899445-69-3
SMILES
[H][C@@](O)(COC(=O)CCCCCCCCCCCCCCCCCCC)COP(O)(=O)OCCN
InChI Identifier
InChI=1S/C25H52NO7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-25(28)31-22-24(27)23-33-34(29,30)32-21-20-26/h24,27H,2-23,26H2,1H3,(H,29,30)/t24-/m1/s1
InChI KeyHEQMDGOBDIGJOC-XMMPIXPASA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 1-acyl-sn-glycero-3-phosphoethanolamines. These are glycerophoethanolamines in which the glycerol is esterified with a fatty acid at O-1 position, and linked at position 3 to a phosphoethanolamine.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphoethanolamines
Direct Parent1-acyl-sn-glycero-3-phosphoethanolamines
Alternative Parents
Substituents
  • 1-monoacyl-sn-glycero-3-phosphoethanolamine
  • Phosphoethanolamine
  • Fatty acid ester
  • Dialkyl phosphate
  • Organic phosphoric acid derivative
  • Fatty acyl
  • Alkyl phosphate
  • Phosphoric acid ester
  • Amino acid or derivatives
  • Carboxylic acid ester
  • Secondary alcohol
  • Carboxylic acid derivative
  • Monocarboxylic acid or derivatives
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Alcohol
  • Primary aliphatic amine
  • Organic oxide
  • Organopnictogen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Organic oxygen compound
  • Amine
  • Organooxygen compound
  • Primary amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Adverse health effect

Disposition

Biological location

Source

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.00097 g/LALOGPS
logP5.47ALOGPS
logP5.31ChemAxon
logS-5.7ALOGPS
pKa (Strongest Acidic)1.87ChemAxon
pKa (Strongest Basic)10ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area128.31 ŲChemAxon
Rotatable Bond Count27ChemAxon
Refractivity135.82 m³·mol⁻¹ChemAxon
Polarizability60.79 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+229.77331661259
DarkChem[M-H]-227.40331661259
DeepCCS[M+H]+203.16830932474
DeepCCS[M-H]-200.8130932474
DeepCCS[M-2H]-234.1630932474
DeepCCS[M+Na]+209.38330932474
AllCCS[M+H]+233.232859911
AllCCS[M+H-H2O]+231.832859911
AllCCS[M+NH4]+234.532859911
AllCCS[M+Na]+234.832859911
AllCCS[M-H]-225.532859911
AllCCS[M+Na-2H]-228.732859911
AllCCS[M+HCOO]-232.332859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
LysoPE(20:0/0:0)[H][C@@](O)(COC(=O)CCCCCCCCCCCCCCCCCCC)COP(O)(=O)OCCN3654.2Standard polar33892256
LysoPE(20:0/0:0)[H][C@@](O)(COC(=O)CCCCCCCCCCCCCCCCCCC)COP(O)(=O)OCCN3455.7Standard non polar33892256
LysoPE(20:0/0:0)[H][C@@](O)(COC(=O)CCCCCCCCCCCCCCCCCCC)COP(O)(=O)OCCN3820.7Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
LysoPE(20:0/0:0),1TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)O[Si](C)(C)C3743.3Semi standard non polar33892256
LysoPE(20:0/0:0),1TMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN)O[Si](C)(C)C3758.3Semi standard non polar33892256
LysoPE(20:0/0:0),1TMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN[Si](C)(C)C3826.9Semi standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C)O[Si](C)(C)C3749.2Semi standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C)O[Si](C)(C)C3523.4Standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C)O[Si](C)(C)C5222.1Standard polar33892256
LysoPE(20:0/0:0),2TMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C)O[Si](C)(C)C3822.1Semi standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C)O[Si](C)(C)C3680.8Standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C)O[Si](C)(C)C5091.5Standard polar33892256
LysoPE(20:0/0:0),2TMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C3810.4Semi standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C3711.2Standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C4493.2Standard polar33892256
LysoPE(20:0/0:0),2TMS,isomer #4CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C4033.7Semi standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #4CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C3727.3Standard non polar33892256
LysoPE(20:0/0:0),2TMS,isomer #4CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C5107.8Standard polar33892256
LysoPE(20:0/0:0),3TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3805.6Semi standard non polar33892256
LysoPE(20:0/0:0),3TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3678.1Standard non polar33892256
LysoPE(20:0/0:0),3TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C4202.5Standard polar33892256
LysoPE(20:0/0:0),3TMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C4054.3Semi standard non polar33892256
LysoPE(20:0/0:0),3TMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C3717.9Standard non polar33892256
LysoPE(20:0/0:0),3TMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C4759.0Standard polar33892256
LysoPE(20:0/0:0),3TMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C4054.3Semi standard non polar33892256
LysoPE(20:0/0:0),3TMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C3741.0Standard non polar33892256
LysoPE(20:0/0:0),3TMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C4295.2Standard polar33892256
LysoPE(20:0/0:0),4TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C4073.6Semi standard non polar33892256
LysoPE(20:0/0:0),4TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C3717.0Standard non polar33892256
LysoPE(20:0/0:0),4TMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN([Si](C)(C)C)[Si](C)(C)C)O[Si](C)(C)C)O[Si](C)(C)C4045.8Standard polar33892256
LysoPE(20:0/0:0),1TBDMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)O[Si](C)(C)C(C)(C)C4022.9Semi standard non polar33892256
LysoPE(20:0/0:0),1TBDMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN)O[Si](C)(C)C(C)(C)C3998.0Semi standard non polar33892256
LysoPE(20:0/0:0),1TBDMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN[Si](C)(C)C(C)(C)C4089.0Semi standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4245.9Semi standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3752.3Standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C5116.3Standard polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4320.5Semi standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3917.5Standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4977.8Standard polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4311.0Semi standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C3935.9Standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4539.4Standard polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #4CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C4521.9Semi standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #4CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3939.9Standard non polar33892256
LysoPE(20:0/0:0),2TBDMS,isomer #4CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C5008.5Standard polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4541.4Semi standard non polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4018.5Standard non polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #1CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(OCCN[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4334.6Standard polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4790.6Semi standard non polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4060.9Standard non polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #2CCCCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4692.1Standard polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4764.6Semi standard non polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4062.0Standard non polar33892256
LysoPE(20:0/0:0),3TBDMS,isomer #3CCCCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(OCCN([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C4396.8Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - LysoPE(20:0/0:0) GC-MS (Non-derivatized) - 70eV, Positivesplash10-0gbc-3920200000-0efc847bf5001cdfad4b2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - LysoPE(20:0/0:0) GC-MS (1 TMS) - 70eV, Positivesplash10-0329-4190200000-89f10b5cb2675325d2ae2017-10-06Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 10V, Positive-QTOFsplash10-0006-9111010000-069aa0725da01d7871022017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 20V, Positive-QTOFsplash10-0006-9121000000-cd2b0817372d87a2355e2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 40V, Positive-QTOFsplash10-0006-9130000000-666de551a7fd28da07032017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 10V, Negative-QTOFsplash10-06r6-2489550000-be9fc03087bf42ca1d352017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 20V, Negative-QTOFsplash10-01r6-9657100000-e61378182869ee0ed8892017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 40V, Negative-QTOFsplash10-01t9-9100000000-eb380163bfa7f2f0ba112017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 10V, Positive-QTOFsplash10-03di-3003090000-c13188261dabdfec04102021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 20V, Positive-QTOFsplash10-00kf-9104200000-5d1a70f68aa386e775ef2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 40V, Positive-QTOFsplash10-0006-9300000000-92a9f11483cee2b5cd752021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 10V, Negative-QTOFsplash10-0a4i-0000490000-f1ea2cdea550e326a3052021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 20V, Negative-QTOFsplash10-03di-2539240000-133a041f021264a70bb22021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - LysoPE(20:0/0:0) 40V, Negative-QTOFsplash10-03di-1309000000-9cb5913bfb8193d931502021-09-24Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
Tissue Locations
  • All Tissues
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Hepatocellular carcinoma
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Liver Cirrhosis
details
Associated Disorders and Diseases
Disease References
Hepatocellular carcinoma
  1. Ressom HW, Xiao JF, Tuli L, Varghese RS, Zhou B, Tsai TH, Ranjbar MR, Zhao Y, Wang J, Di Poto C, Cheema AK, Tadesse MG, Goldman R, Shetty K: Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. Anal Chim Acta. 2012 Sep 19;743:90-100. doi: 10.1016/j.aca.2012.07.013. Epub 2012 Jul 20. [PubMed:22882828 ]
Cirrhosis
  1. Ressom HW, Xiao JF, Tuli L, Varghese RS, Zhou B, Tsai TH, Ranjbar MR, Zhao Y, Wang J, Di Poto C, Cheema AK, Tadesse MG, Goldman R, Shetty K: Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis. Anal Chim Acta. 2012 Sep 19;743:90-100. doi: 10.1016/j.aca.2012.07.013. Epub 2012 Jul 20. [PubMed:22882828 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB028227
KNApSAcK IDNot Available
Chemspider ID24769389
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound52925131
PDB IDNot Available
ChEBI ID131690
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  2. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  3. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  4. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  5. Divecha N, Irvine RF: Phospholipid signaling. Cell. 1995 Jan 27;80(2):269-78. [PubMed:7834746 ]
  6. Cevc, Gregor (1993). Phospholipids Handbook. Marcel Dekker.
  7. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Enzymes

General function:
Involved in catalytic activity
Specific function:
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Gene Name:
ENPP2
Uniprot ID:
Q13822
Molecular weight:
98992.78