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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2009-03-03 11:17:37 UTC
Update Date2021-09-14 15:41:42 UTC
HMDB IDHMDB0011738
Secondary Accession Numbers
  • HMDB11738
Metabolite Identification
Common NameN2-gamma-Glutamylglutamine
DescriptionN2-gamma-Glutamylglutamine, also known as gamma-L-Glu-L-Gln or L-gamma-glutamyl-L-glutamine, belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. N2-gamma-Glutamylglutamine is a very strong basic compound (based on its pKa). N2-gamma-Glutamylglutamine is a dipeptide obtained from the condensation of the gamma-carboxy group of glutamic acid with the alpha-amino group of glutamine. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Structure
Data?1582752945
Synonyms
ValueSource
gamma-L-Glu-L-GLNChEBI
g-L-Glu-L-GLNGenerator
Γ-L-glu-L-GLNGenerator
N2-g-GlutamylglutamineGenerator
N2-Γ-glutamylglutamineGenerator
γ-Glu-GlnHMDB, Generator
γ-GlutamylglutamineHMDB, Generator
γ-L-Glutamyl-L-glutamineHMDB
L-γ-Glutamyl-L-glutamineHMDB
N2-L-γ-GlutamylglutamineHMDB
N2-L-γ-Glutamyl-L-glutamineHMDB
gamma-Glu-GlnHMDB, MeSH
gamma-GlutamylglutamineHMDB
gamma-L-Glutamyl-L-glutamineHMDB
L-gamma-Glutamyl-L-glutamineHMDB
N2-L-gamma-GlutamylglutamineHMDB
N2-L-gamma-Glutamyl-L-glutamineHMDB
N2-gamma-GlutamylglutamineHMDB
g-Glutamyl glutamineGenerator, HMDB
γ-glutamyl glutamineGenerator, HMDB
g-Glu-GlnGenerator, HMDB
g-GlutamylglutamineGenerator, HMDB
Chemical FormulaC10H17N3O6
Average Molecular Weight275.2585
Monoisotopic Molecular Weight275.111735291
IUPAC Name(2S)-2-[(4S)-4-amino-4-carboxybutanamido]-4-carbamoylbutanoic acid
Traditional Name(2S)-2-[(4S)-4-amino-4-carboxybutanamido]-4-carbamoylbutanoic acid
CAS Registry Number10148-81-9
SMILES
N[C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(O)=O
InChI Identifier
InChI=1S/C10H17N3O6/c11-5(9(16)17)1-4-8(15)13-6(10(18)19)2-3-7(12)14/h5-6H,1-4,11H2,(H2,12,14)(H,13,15)(H,16,17)(H,18,19)/t5-,6-/m0/s1
InChI KeyJBFYFLXEJFQWMU-WDSKDSINSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentDipeptides
Alternative Parents
Substituents
  • Alpha-dipeptide
  • Gamma-glutamyl alpha-amino acid
  • Glutamine or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-l-alpha-amino acid
  • N-acyl-l-glutamine
  • Alpha-amino acid
  • Alpha-amino acid or derivatives
  • L-alpha-amino acid
  • N-acyl-amine
  • Fatty acyl
  • Fatty acid
  • Dicarboxylic acid or derivatives
  • Fatty amide
  • Secondary carboxylic acid amide
  • Primary carboxylic acid amide
  • Amino acid or derivatives
  • Carboxamide group
  • Amino acid
  • Carboxylic acid
  • Organic nitrogen compound
  • Primary aliphatic amine
  • Organonitrogen compound
  • Organooxygen compound
  • Primary amine
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Organopnictogen compound
  • Amine
  • Organic oxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Spectral PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility6.17 g/LALOGPS
logP10(-3.6) g/LALOGPS
logP10(-5) g/LChemAxon
logS10(-1.6) g/LALOGPS
pKa (Strongest Acidic)1.93ChemAxon
pKa (Strongest Basic)9.31ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area172.81 ŲChemAxon
Rotatable Bond Count9ChemAxon
Refractivity61.2 m³·mol⁻¹ChemAxon
Polarizability26.12 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Spectral Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+164.91231661259
DarkChem[M-H]-161.73131661259

Predicted Kovats Retention Indices

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
N2-gamma-Glutamylglutamine,1TMS,#1C[Si](C)(C)OC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@H](N)C(=O)O2579.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TMS,#2C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CCC(N)=O)C(=O)O2551.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TMS,#3C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O)C(=O)O2634.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TMS,#4C[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O2656.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TMS,#5C[Si](C)(C)N(C(=O)CC[C@H](N)C(=O)O)[C@@H](CCC(N)=O)C(=O)O2595.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#1C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CCC(N)=O)C(=O)O[Si](C)(C)C2558.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#2C[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O[Si](C)(C)C2638.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#3C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O[Si](C)(C)C)C(=O)O2640.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#4C[Si](C)(C)OC(=O)[C@H](CCC(N)=O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C2588.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#5C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O)C(=O)O[Si](C)(C)C2629.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#6C[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)O2620.4Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#7C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N([C@@H](CCC(N)=O)C(=O)O)[Si](C)(C)C2557.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#8C[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)O2706.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#9C[Si](C)(C)N([C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O)C(=O)O)[Si](C)(C)C2778.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#10C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CCC(N)=O)C(=O)O)[Si](C)(C)C)C(=O)O2641.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#11C[Si](C)(C)N(C(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O)[Si](C)(C)C2768.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TMS,#12C[Si](C)(C)NC(=O)CC[C@@H](C(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C2641.8Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TBDMS,#1CC(C)(C)[Si](C)(C)OC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@H](N)C(=O)O2838.8Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TBDMS,#2CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CCC(N)=O)C(=O)O2822.8Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TBDMS,#3CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O)C(=O)O2890.6Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TBDMS,#4CC(C)(C)[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O2924.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,1TBDMS,#5CC(C)(C)[Si](C)(C)N(C(=O)CC[C@H](N)C(=O)O)[C@@H](CCC(N)=O)C(=O)O2858.0Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CCC(N)=O)C(=O)O[Si](C)(C)C(C)(C)C3043.5Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#2CC(C)(C)[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O[Si](C)(C)C(C)(C)C3114.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#3CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O3113.8Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#4CC(C)(C)[Si](C)(C)OC(=O)[C@H](CCC(N)=O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C3065.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#5CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O)C(=O)O[Si](C)(C)C(C)(C)C3109.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#6CC(C)(C)[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O3105.1Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#7CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N([C@@H](CCC(N)=O)C(=O)O)[Si](C)(C)C(C)(C)C3050.3Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#8CC(C)(C)[Si](C)(C)NC(=O)CC[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)C(=O)O3201.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#9CC(C)(C)[Si](C)(C)N([C@@H](CCC(=O)N[C@@H](CCC(N)=O)C(=O)O)C(=O)O)[Si](C)(C)C(C)(C)C3239.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#10CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CCC(N)=O)C(=O)O)[Si](C)(C)C(C)(C)C)C(=O)O3112.7Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#11CC(C)(C)[Si](C)(C)N(C(=O)CC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O)[Si](C)(C)C(C)(C)C3231.2Semi standard non polarhttps://arxiv.org/abs/1905.12712
N2-gamma-Glutamylglutamine,2TBDMS,#12CC(C)(C)[Si](C)(C)NC(=O)CC[C@@H](C(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C3131.9Semi standard non polarhttps://arxiv.org/abs/1905.12712
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - N2-gamma-Glutamylglutamine GC-MS (Non-derivatized) - 70eV, Positivesplash10-001l-9560000000-a956f772592da08ac91b2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - N2-gamma-Glutamylglutamine GC-MS (2 TMS) - 70eV, Positivesplash10-00dl-9314100000-7288034a17d80463b7ca2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - N2-gamma-Glutamylglutamine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - N2-gamma-Glutamylglutamine LC-ESI-IT , positive-QTOFsplash10-0002-0900000000-aa0c06e268e954c251792017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 35V, Positive-QTOFsplash10-001i-4910000000-600a5db0fe0b0ab51aa02021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 35V, Negative-QTOFsplash10-0002-0900000000-f58241fb59526b57df2d2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 10V, Positive-QTOFsplash10-0a59-0290000000-53ebbfe26a1610c7d2062017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 20V, Positive-QTOFsplash10-01q9-1790000000-8b9c77dbe3ee9bfa33602017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 40V, Positive-QTOFsplash10-0a59-9600000000-7cf2074b159a06a79e692017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 10V, Negative-QTOFsplash10-05fr-0090000000-1e9b60fa2e6418acc3322017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 20V, Negative-QTOFsplash10-0bvm-3590000000-ebbac377891f30e322da2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 40V, Negative-QTOFsplash10-0006-9300000000-3685d99d954b21693f1c2017-09-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 10V, Positive-QTOFsplash10-003r-1890000000-67e2a8a728d6d92849002021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 20V, Positive-QTOFsplash10-001i-7920000000-b10be01edd52864984d92021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 40V, Positive-QTOFsplash10-0f89-9400000000-0858c9106ad20fc5ab292021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 10V, Negative-QTOFsplash10-05i1-0690000000-69500aeda2576335308b2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 20V, Negative-QTOFsplash10-002e-4930000000-4726b064634cf0a3ba472021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - N2-gamma-Glutamylglutamine 40V, Negative-QTOFsplash10-0006-9300000000-c59d2d2a2410fa5f76502021-09-22Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
Tissue Locations
  • Placenta
  • Prostate
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
Cerebrospinal Fluid (CSF)Detected and Quantified2.46 +/- 0.47 uMAdult (>18 years old)BothNormal details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified117.00 (20.00-214.00) uMAdult (>18 years old)BothHyperammonemia details
Cerebrospinal Fluid (CSF)Detected and Quantified2.07 +/- 0.52 uMAdult (>18 years old)BothSchizophrenia details
Cerebrospinal Fluid (CSF)Detected and Quantified258.00 uMAdult (>18 years old)BothHyperammonemia details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothCrohns disease details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothIron deficiency details
Associated Disorders and Diseases
Disease References
Hyperammonemia
  1. Hammond JW, Potter M, Truscott R, Wilcken B: gamma-Glutamylglutamine identified in plasma and cerebrospinal fluid from hyperammonaemic patients. Clin Chim Acta. 1990 Dec 24;194(2-3):173-83. [PubMed:2093471 ]
Schizophrenia
  1. Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuenod M, Holsboer F: gamma-Glutamylglutamine and taurine concentrations are decreased in the cerebrospinal fluid of drug-naive patients with schizophrenic disorders. J Neurochem. 1995 Dec;65(6):2652-62. [PubMed:7595563 ]
Crohn's disease
  1. Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4. [PubMed:26848182 ]
Iron deficiency
  1. Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D: Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4. [PubMed:26848182 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB028416
KNApSAcK IDNot Available
Chemspider ID133013
KEGG Compound IDC05283
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound150914
PDB IDNot Available
ChEBI ID73707
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. doi: 10.1038/nature07762. [PubMed:19212411 ]
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