Hmdb loader
Survey
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:00:52 UTC
Update Date2020-02-26 21:39:21 UTC
HMDB IDHMDB0014024
Secondary Accession Numbers
  • HMDB14024
Metabolite Identification
Common Name2-Hydroxychlorpropamide
Description2-Hydroxychlorpropamide belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring. Based on a literature review very few articles have been published on 2-Hydroxychlorpropamide.
Structure
Data?1582753161
Synonyms
ValueSource
N-(4-Chloro-2-hydroxybenzenesulfonyl)propane-1-carbamimidateHMDB
N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidateHMDB
N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidic acidHMDB
Chemical FormulaC10H13ClN2O4S
Average Molecular Weight292.739
Monoisotopic Molecular Weight292.028455311
IUPAC Name1-(4-chloro-2-hydroxybenzenesulfonyl)-3-propylurea
Traditional Name1-(4-chloro-2-hydroxybenzenesulfonyl)-3-propylurea
CAS Registry Number36892-36-1
SMILES
CCCNC(=O)NS(=O)(=O)C1=C(O)C=C(Cl)C=C1
InChI Identifier
InChI=1S/C10H13ClN2O4S/c1-2-5-12-10(15)13-18(16,17)9-4-3-7(11)6-8(9)14/h3-4,6,14H,2,5H2,1H3,(H2,12,13,15)
InChI KeyQRXRPQPWKRLTQX-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentBenzenesulfonamides
Alternative Parents
Substituents
  • Benzenesulfonamide
  • Benzenesulfonyl group
  • 3-chlorophenol
  • 3-halophenol
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Chlorobenzene
  • Halobenzene
  • Sulfonylurea
  • Phenol
  • Aryl chloride
  • Aryl halide
  • Aminosulfonyl compound
  • Organic sulfonic acid or derivatives
  • Organosulfonic acid or derivatives
  • Sulfonyl
  • Carbonic acid derivative
  • Organic nitrogen compound
  • Organochloride
  • Organohalogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Organosulfur compound
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Organopnictogen compound
  • Organic oxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.54 g/LALOGPS
logP1.78ALOGPS
logP1.64ChemAxon
logS-2.7ALOGPS
pKa (Strongest Acidic)4.25ChemAxon
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area95.5 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity67.41 m³·mol⁻¹ChemAxon
Polarizability27.88 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+165.16430932474
DeepCCS[M-H]-162.80630932474
DeepCCS[M-2H]-195.69230932474
DeepCCS[M+Na]+171.25730932474
AllCCS[M+H]+161.732859911
AllCCS[M+H-H2O]+158.432859911
AllCCS[M+NH4]+164.632859911
AllCCS[M+Na]+165.532859911
AllCCS[M-H]-159.432859911
AllCCS[M+Na-2H]-159.932859911
AllCCS[M+HCOO]-160.432859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
2-HydroxychlorpropamideCCCNC(=O)NS(=O)(=O)C1=C(O)C=C(Cl)C=C13761.8Standard polar33892256
2-HydroxychlorpropamideCCCNC(=O)NS(=O)(=O)C1=C(O)C=C(Cl)C=C11845.9Standard non polar33892256
2-HydroxychlorpropamideCCCNC(=O)NS(=O)(=O)C1=C(O)C=C(Cl)C=C12405.3Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
2-Hydroxychlorpropamide,1TMS,isomer #1CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C2451.6Semi standard non polar33892256
2-Hydroxychlorpropamide,1TMS,isomer #2CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C2428.6Semi standard non polar33892256
2-Hydroxychlorpropamide,1TMS,isomer #3CCCNC(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O2375.7Semi standard non polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #1CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C)[Si](C)(C)C2392.8Semi standard non polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #1CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C)[Si](C)(C)C2578.3Standard non polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #1CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C)[Si](C)(C)C3077.8Standard polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #2CCCNC(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C2366.3Semi standard non polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #2CCCNC(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C2466.4Standard non polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #2CCCNC(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C3190.7Standard polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #3CCCN(C(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C2347.4Semi standard non polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #3CCCN(C(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C2605.3Standard non polar33892256
2-Hydroxychlorpropamide,2TMS,isomer #3CCCN(C(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C3139.2Standard polar33892256
2-Hydroxychlorpropamide,3TMS,isomer #1CCCN(C(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C)[Si](C)(C)C2357.1Semi standard non polar33892256
2-Hydroxychlorpropamide,3TMS,isomer #1CCCN(C(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C)[Si](C)(C)C2729.4Standard non polar33892256
2-Hydroxychlorpropamide,3TMS,isomer #1CCCN(C(=O)N([Si](C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C)[Si](C)(C)C2886.0Standard polar33892256
2-Hydroxychlorpropamide,1TBDMS,isomer #1CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C2696.0Semi standard non polar33892256
2-Hydroxychlorpropamide,1TBDMS,isomer #2CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C(C)(C)C2639.4Semi standard non polar33892256
2-Hydroxychlorpropamide,1TBDMS,isomer #3CCCNC(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O2633.6Semi standard non polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #1CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2839.2Semi standard non polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #1CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3053.4Standard non polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #1CCCN(C(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3179.6Standard polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #2CCCNC(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C2870.0Semi standard non polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #2CCCNC(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C2961.5Standard non polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #2CCCNC(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C3285.8Standard polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #3CCCN(C(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C(C)(C)C2845.8Semi standard non polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #3CCCN(C(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C(C)(C)C3089.7Standard non polar33892256
2-Hydroxychlorpropamide,2TBDMS,isomer #3CCCN(C(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O)[Si](C)(C)C(C)(C)C3213.4Standard polar33892256
2-Hydroxychlorpropamide,3TBDMS,isomer #1CCCN(C(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3084.7Semi standard non polar33892256
2-Hydroxychlorpropamide,3TBDMS,isomer #1CCCN(C(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3456.9Standard non polar33892256
2-Hydroxychlorpropamide,3TBDMS,isomer #1CCCN(C(=O)N([Si](C)(C)C(C)(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3107.1Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxychlorpropamide GC-MS (Non-derivatized) - 70eV, Positivesplash10-000x-9450000000-1a9dcbaec46772bb8ea42017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxychlorpropamide GC-MS (1 TMS) - 70eV, Positivesplash10-06y5-9334000000-0f44acebf63c310f4f1a2017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 2-Hydroxychlorpropamide GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 10V, Positive-QTOFsplash10-052f-5190000000-b69d76e6feb14c38b5932016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 20V, Positive-QTOFsplash10-0a4l-9130000000-4f6b359685f9420587b22016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 40V, Positive-QTOFsplash10-0006-9000000000-450c7b3500a73b5fc1362016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 10V, Negative-QTOFsplash10-052f-1090000000-2075b36bd6fe07e54c8c2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 20V, Negative-QTOFsplash10-0a4i-1490000000-eac89c0c66f634146b172016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 40V, Negative-QTOFsplash10-0a6u-9650000000-3c709b2c69e56ec332bb2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 10V, Negative-QTOFsplash10-0a4i-0090000000-7eaf818eed6f83d0bbe82021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 20V, Negative-QTOFsplash10-056r-9380000000-d7ad14cfc029d3b6d14d2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 40V, Negative-QTOFsplash10-001i-9000000000-a429604b1811891f08a92021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 10V, Positive-QTOFsplash10-0a4l-0190000000-7af27b5ba9f99046ca4f2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 20V, Positive-QTOFsplash10-0006-9730000000-e301ba1108e008a087222021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 2-Hydroxychlorpropamide 40V, Positive-QTOFsplash10-0006-6910000000-9245d5364196e9d243622021-09-24Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
Biospecimen Locations
  • Blood
  • Urine
Tissue Locations
  • Kidney
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID30776728
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound131750723
PDB IDNot Available
ChEBI ID143296
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in peroxidase activity
Specific function:
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular weight:
68685.82
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in ATP binding
Specific function:
Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release
Gene Name:
ABCC8
Uniprot ID:
Q09428
Molecular weight:
177006.4
References
  1. Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA, Avery MA: Type 2 diabetes and oral antihyperglycemic drugs. Curr Med Chem. 2008;15(1):61-74. [PubMed:18220763 ]

Transporters

General function:
Involved in ATP binding
Specific function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular weight:
141477.3
References
  1. Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. [PubMed:11082465 ]
General function:
Involved in transporter activity
Specific function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products
Gene Name:
SLC15A1
Uniprot ID:
P46059
Molecular weight:
78805.3
References
  1. Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. [PubMed:10748266 ]
General function:
Involved in transporter activity
Specific function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides
Gene Name:
SLC15A2
Uniprot ID:
Q16348
Molecular weight:
81782.8
References
  1. Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. [PubMed:10748266 ]
General function:
Involved in ion transmembrane transporter activity
Specific function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular weight:
61815.8
References
  1. Uwai Y, Saito H, Hashimoto Y, Inui K: Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1. Eur J Pharmacol. 2000 Jun 16;398(2):193-7. [PubMed:10854830 ]