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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2020-02-26 21:40:20 UTC
HMDB IDHMDB0014781
Secondary Accession Numbers
  • HMDB14781
Metabolite Identification
Common NameMebendazole
DescriptionMebendazole is only found in individuals that have used or taken this drug. It is a benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Structure
Data?1582753220
Synonyms
ValueSource
(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl esterChEBI
MBDZChEBI
VermoxChEBI
(5-Benzoyl-1H-benzimidazol-2-yl)-carbamate methyl esterGenerator
Abello farmacia brand OF mebendazoleHMDB
Anti wormHMDB
Anti-wormHMDB
Esteve brand OF mebendazoleHMDB
Pfizer brand OF mebendazoleHMDB
SSL Brand OF mebendazoleHMDB
SufilHMDB
TelminHMDB
VermidilHMDB
Ardeypharm brand OF mebendazoleHMDB
Boots threadworm treatmentHMDB
Healthypharm brand OF mebendazoleHMDB
Norgine brand OF mebendazoleHMDB
Pripsen mebendazoleHMDB
SqwormHMDB
Streger brand OF mebendazoleHMDB
Taxandria brand OF mebendazoleHMDB
Tedec meiji brand OF mebendazoleHMDB
BantenolHMDB
Diba brand OF mebendazoleHMDB
Leidapharm brand OF mebendazoleHMDB
LomperHMDB
MadicureHMDB
MebendanHMDB
SurfontHMDB
WormkuurHMDB
BanwormHMDB
Boots brand OF mebendazoleHMDB
Degort's brand OF mebendazoleHMDB
Elfar brand OF mebendazoleHMDB
Janssen brand OF mebendazoleHMDB
MebenvetHMDB
VermicolHMDB
VerminHMDB
Chemical FormulaC16H13N3O3
Average Molecular Weight295.2927
Monoisotopic Molecular Weight295.095691297
IUPAC Namemethyl N-(6-benzoyl-1H-1,3-benzodiazol-2-yl)carbamate
Traditional Namemebendazole
CAS Registry Number31431-39-7
SMILES
COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1
InChI Identifier
InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
InChI KeyOPXLLQIJSORQAM-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzophenones
Direct ParentBenzophenones
Alternative Parents
Substituents
  • 2-benzimidazolylcarbamic acid ester
  • Benzophenone
  • Aryl-phenylketone
  • Benzimidazole
  • Benzoyl
  • Aryl ketone
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Carbamic acid ester
  • Ketone
  • Carbonic acid derivative
  • Azacycle
  • Organoheterocyclic compound
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Hydrocarbon derivative
  • Carbonyl group
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point288.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.039 g/LNot Available
LogP2.8Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available171.166http://allccs.zhulab.cn/database/detail?ID=AllCCS00000775
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.039 g/LALOGPS
logP10(2.95) g/LALOGPS
logP10(3.26) g/LChemAxon
logS10(-3.9) g/LALOGPS
pKa (Strongest Acidic)8.44ChemAxon
pKa (Strongest Basic)3.93ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area84.08 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity81.5 m³·mol⁻¹ChemAxon
Polarizability31.1 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+172.31331661259
DarkChem[M-H]-173.02931661259

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
MebendazoleCOC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C13999.6Standard polar33892256
MebendazoleCOC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C12448.0Standard non polar33892256
MebendazoleCOC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C13176.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Mebendazole,1TMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2[NH]1)[Si](C)(C)C2719.6Semi standard non polar33892256
Mebendazole,1TMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2[NH]1)[Si](C)(C)C2619.1Standard non polar33892256
Mebendazole,1TMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2[NH]1)[Si](C)(C)C3777.2Standard polar33892256
Mebendazole,1TMS,isomer #2COC(=O)NC1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C2795.7Semi standard non polar33892256
Mebendazole,1TMS,isomer #2COC(=O)NC1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C2617.4Standard non polar33892256
Mebendazole,1TMS,isomer #2COC(=O)NC1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C3849.0Standard polar33892256
Mebendazole,2TMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C)[Si](C)(C)C2743.9Semi standard non polar33892256
Mebendazole,2TMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C)[Si](C)(C)C2609.1Standard non polar33892256
Mebendazole,2TMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C)[Si](C)(C)C3390.3Standard polar33892256
Mebendazole,1TBDMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2[NH]1)[Si](C)(C)C(C)(C)C2925.3Semi standard non polar33892256
Mebendazole,1TBDMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2[NH]1)[Si](C)(C)C(C)(C)C2848.8Standard non polar33892256
Mebendazole,1TBDMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2[NH]1)[Si](C)(C)C(C)(C)C3771.2Standard polar33892256
Mebendazole,1TBDMS,isomer #2COC(=O)NC1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C(C)(C)C2998.2Semi standard non polar33892256
Mebendazole,1TBDMS,isomer #2COC(=O)NC1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C(C)(C)C2879.0Standard non polar33892256
Mebendazole,1TBDMS,isomer #2COC(=O)NC1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C(C)(C)C3832.3Standard polar33892256
Mebendazole,2TBDMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3137.6Semi standard non polar33892256
Mebendazole,2TBDMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3063.2Standard non polar33892256
Mebendazole,2TBDMS,isomer #1COC(=O)N(C1=NC2=CC=C(C(=O)C3=CC=CC=C3)C=C2N1[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3489.7Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Mebendazole GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4i-0980000000-8fb2e53ed97aff8020762017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Mebendazole GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-03dl-0090000000-8828fc1fa56f3c2e418e2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-03di-0090000000-024c6803f14cfb0e01142017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-03di-0090000000-5d24c800cdbe57cde52a2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-03di-0190000000-cc4b2fea662fc4e5f7442017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-03di-0980000000-6e83d7d5064bd98808022017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-0a4i-0910000000-b02640332388531fd0fd2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-0ar0-0900000000-d45befbb5c042b2c63002017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-016r-2900000000-7e5eb3a1870c7b34c1422017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-03xr-9600000000-ae4ce30813b2e793a7e72017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , negative-QTOFsplash10-03di-0090000000-85dd5a77b566811c09d72017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QTOF , positive-QTOFsplash10-0002-0090000000-aa34603c660e8b3f4f172017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QTOF , positive-QTOFsplash10-03dj-0090000000-def7f96fcfca0339b3d12017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QTOF , positive-QTOFsplash10-03di-0090000000-a66ea36d2742df54240b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QTOF , positive-QTOFsplash10-03di-0090000000-b87560a141b5b3d744542017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QTOF , positive-QTOFsplash10-03di-0890000000-d9b1bed9d118fcec0da62017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QTOF , positive-QTOFsplash10-03di-0090000000-d291ee80ffb822eea9c12017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , positive-QTOFsplash10-0002-0090000000-461e3ef8826b0936ecf32017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , positive-QTOFsplash10-03dj-0090000000-0dee2cf61e88f9d5c3252017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Mebendazole LC-ESI-QFT , positive-QTOFsplash10-03di-0090000000-48e3d9d0c50eeb00e28a2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mebendazole 10V, Positive-QTOFsplash10-0002-0190000000-72a1c0130a441700ccd42016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mebendazole 20V, Positive-QTOFsplash10-052r-0490000000-4cd9da50a1f5ad72ab992016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mebendazole 40V, Positive-QTOFsplash10-0a4i-1920000000-833a39ed4472b53f1bd52016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mebendazole 10V, Negative-QTOFsplash10-08fu-2090000000-e90023d258ea536503f42016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mebendazole 20V, Negative-QTOFsplash10-03di-2190000000-66b04d9ac6355a1625962016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Mebendazole 40V, Negative-QTOFsplash10-001i-3890000000-e68bbe64bca0347703762016-08-03Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00643 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00643 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00643
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3890
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMebendazole
METLIN IDNot Available
PubChem Compound4030
PDB IDNot Available
ChEBI ID6704
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Wikipedia [Link]

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular weight:
58164.815
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBB2C
Uniprot ID:
P68371
Molecular weight:
49830.7
References
  1. Lubega GW, Geary TG, Klein RD, Prichard RK: Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole. Mol Biochem Parasitol. 1993 Dec;62(2):281-92. [PubMed:8139621 ]
  2. MacDonald LM, Armson A, Thompson AR, Reynoldson JA: Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum. Mol Biochem Parasitol. 2004 Nov;138(1):89-96. [PubMed:15500920 ]
  3. Oxberry ME, Gear TG, Prichard RK: Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus. Parasitology. 2001 Jun;122(Pt 6):683-7. [PubMed:11444621 ]
  4. Ochola DO, Prichard RK, Lubega GW: Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro. J Parasitol. 2002 Jun;88(3):600-4. [PubMed:12099434 ]
  5. Wampande EM, Richard McIntosh J, Lubega GW: Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude. Protein Expr Purif. 2007 Oct;55(2):236-45. Epub 2007 Apr 25. [PubMed:17662615 ]
  6. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
General function:
Involved in structural molecule activity
Specific function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Gene Name:
TUBA1A
Uniprot ID:
Q71U36
Molecular weight:
50135.2
References
  1. Lubega GW, Geary TG, Klein RD, Prichard RK: Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole. Mol Biochem Parasitol. 1993 Dec;62(2):281-92. [PubMed:8139621 ]
  2. MacDonald LM, Armson A, Thompson AR, Reynoldson JA: Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum. Mol Biochem Parasitol. 2004 Nov;138(1):89-96. [PubMed:15500920 ]
  3. Oxberry ME, Gear TG, Prichard RK: Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus. Parasitology. 2001 Jun;122(Pt 6):683-7. [PubMed:11444621 ]
  4. Ochola DO, Prichard RK, Lubega GW: Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro. J Parasitol. 2002 Jun;88(3):600-4. [PubMed:12099434 ]
  5. Wampande EM, Richard McIntosh J, Lubega GW: Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude. Protein Expr Purif. 2007 Oct;55(2):236-45. Epub 2007 Apr 25. [PubMed:17662615 ]
  6. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Transporters

General function:
Involved in ATP binding
Specific function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular weight:
141477.3
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]