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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2022-03-07 02:51:47 UTC
HMDB IDHMDB0014938
Secondary Accession Numbers
  • HMDB14938
Metabolite Identification
Common NameFenoldopam
DescriptionFenoldopam is only found in individuals that have used or taken this drug. It is a dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. [PubChem]Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D1-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D2-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam may increase norepinephrine plasma concentration.
Structure
Data?1582753237
Synonyms
ValueSource
FenoldopamumChEBI
CarlacorKegg
CorlopamMeSH, HMDB
SK And F 82526JMeSH, HMDB
Fenoldopam hydrobromideMeSH, HMDB
SK And F82526MeSH, HMDB
Fenoldopam mesylateMeSH, HMDB
Hydrobromide, fenoldopamMeSH, HMDB
SK And F 82526MeSH, HMDB
SK And F-82526MeSH, HMDB
SK And F-82526JMeSH, HMDB
SK And F82526JMeSH, HMDB
Chemical FormulaC16H16ClNO3
Average Molecular Weight305.756
Monoisotopic Molecular Weight305.08187109
IUPAC Name6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Traditional Namefenoldopam
CAS Registry Number67227-57-0
SMILES
OC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C12
InChI Identifier
InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2
InChI KeyTVURRHSHRRELCG-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as benzazepines. These are organic compounds containing a benzene ring fused to an azepine ring (unsaturated seven-membered heterocycle with one nitrogen atom replacing a carbon atom).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzazepines
Sub ClassNot Available
Direct ParentBenzazepines
Alternative Parents
Substituents
  • Benzazepine
  • 1-hydroxy-2-unsubstituted benzenoid
  • Azepine
  • Aralkylamine
  • Phenol
  • Aryl chloride
  • Aryl halide
  • Monocyclic benzene moiety
  • Benzenoid
  • Azacycle
  • Secondary aliphatic amine
  • Secondary amine
  • Organochloride
  • Organohalogen compound
  • Amine
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Organic oxygen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Organic nitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.27 g/LNot Available
LogP2Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.27 g/LALOGPS
logP2.39ALOGPS
logP1.92ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)8.12ChemAxon
pKa (Strongest Basic)10.4ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area72.72 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity82.68 m³·mol⁻¹ChemAxon
Polarizability30.71 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M-2H]-202.47730932474
DeepCCS[M+Na]+178.04130932474
AllCCS[M+H]+169.632859911
AllCCS[M+H-H2O]+166.132859911
AllCCS[M+NH4]+172.832859911
AllCCS[M+Na]+173.732859911
AllCCS[M-H]-171.132859911
AllCCS[M+Na-2H]-170.732859911
AllCCS[M+HCOO]-170.432859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
FenoldopamOC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C124176.5Standard polar33892256
FenoldopamOC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C123004.2Standard non polar33892256
FenoldopamOC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C122955.0Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Fenoldopam,1TMS,isomer #1C[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O)C(O)=C3Cl)C=C12927.4Semi standard non polar33892256
Fenoldopam,1TMS,isomer #2C[Si](C)(C)OC1=C(O)C=C2C(=C1Cl)CCNCC2C1=CC=C(O)C=C13009.7Semi standard non polar33892256
Fenoldopam,1TMS,isomer #3C[Si](C)(C)OC1=CC2=C(CCNCC2C2=CC=C(O)C=C2)C(Cl)=C1O2962.1Semi standard non polar33892256
Fenoldopam,1TMS,isomer #4C[Si](C)(C)N1CCC2=C(C=C(O)C(O)=C2Cl)C(C2=CC=C(O)C=C2)C13028.6Semi standard non polar33892256
Fenoldopam,2TMS,isomer #1C[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O[Si](C)(C)C)C(O)=C3Cl)C=C12908.0Semi standard non polar33892256
Fenoldopam,2TMS,isomer #2C[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O)C(O[Si](C)(C)C)=C3Cl)C=C12947.4Semi standard non polar33892256
Fenoldopam,2TMS,isomer #3C[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C)CCC3=C2C=C(O)C(O)=C3Cl)C=C12944.8Semi standard non polar33892256
Fenoldopam,2TMS,isomer #4C[Si](C)(C)OC1=CC2=C(CCNCC2C2=CC=C(O)C=C2)C(Cl)=C1O[Si](C)(C)C2959.6Semi standard non polar33892256
Fenoldopam,2TMS,isomer #5C[Si](C)(C)OC1=C(O)C=C2C(=C1Cl)CCN([Si](C)(C)C)CC2C1=CC=C(O)C=C12980.4Semi standard non polar33892256
Fenoldopam,2TMS,isomer #6C[Si](C)(C)OC1=CC2=C(CCN([Si](C)(C)C)CC2C2=CC=C(O)C=C2)C(Cl)=C1O2967.2Semi standard non polar33892256
Fenoldopam,3TMS,isomer #1C[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C3Cl)C=C12975.2Semi standard non polar33892256
Fenoldopam,3TMS,isomer #2C[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C)CCC3=C2C=C(O[Si](C)(C)C)C(O)=C3Cl)C=C12903.0Semi standard non polar33892256
Fenoldopam,3TMS,isomer #3C[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C)CCC3=C2C=C(O)C(O[Si](C)(C)C)=C3Cl)C=C12925.4Semi standard non polar33892256
Fenoldopam,3TMS,isomer #4C[Si](C)(C)OC1=CC2=C(CCN([Si](C)(C)C)CC2C2=CC=C(O)C=C2)C(Cl)=C1O[Si](C)(C)C2952.1Semi standard non polar33892256
Fenoldopam,4TMS,isomer #1C[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C)CCC3=C2C=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C3Cl)C=C12958.6Semi standard non polar33892256
Fenoldopam,4TMS,isomer #1C[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C)CCC3=C2C=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C3Cl)C=C12934.6Standard non polar33892256
Fenoldopam,4TMS,isomer #1C[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C)CCC3=C2C=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C3Cl)C=C13059.4Standard polar33892256
Fenoldopam,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O)C(O)=C3Cl)C=C13183.5Semi standard non polar33892256
Fenoldopam,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=C(O)C=C2C(=C1Cl)CCNCC2C1=CC=C(O)C=C13280.3Semi standard non polar33892256
Fenoldopam,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=CC2=C(CCNCC2C2=CC=C(O)C=C2)C(Cl)=C1O3255.9Semi standard non polar33892256
Fenoldopam,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)N1CCC2=C(C=C(O)C(O)=C2Cl)C(C2=CC=C(O)C=C2)C13295.7Semi standard non polar33892256
Fenoldopam,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O[Si](C)(C)C(C)(C)C)C(O)=C3Cl)C=C13399.4Semi standard non polar33892256
Fenoldopam,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O)C(O[Si](C)(C)C(C)(C)C)=C3Cl)C=C13470.5Semi standard non polar33892256
Fenoldopam,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C(C)(C)C)CCC3=C2C=C(O)C(O)=C3Cl)C=C13404.5Semi standard non polar33892256
Fenoldopam,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC1=CC2=C(CCNCC2C2=CC=C(O)C=C2)C(Cl)=C1O[Si](C)(C)C(C)(C)C3485.2Semi standard non polar33892256
Fenoldopam,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)OC1=C(O)C=C2C(=C1Cl)CCN([Si](C)(C)C(C)(C)C)CC2C1=CC=C(O)C=C13533.4Semi standard non polar33892256
Fenoldopam,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=CC2=C(CCN([Si](C)(C)C(C)(C)C)CC2C2=CC=C(O)C=C2)C(Cl)=C1O3481.3Semi standard non polar33892256
Fenoldopam,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=C(C2CNCCC3=C2C=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C3Cl)C=C13651.6Semi standard non polar33892256
Fenoldopam,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C(C)(C)C)CCC3=C2C=C(O[Si](C)(C)C(C)(C)C)C(O)=C3Cl)C=C13603.9Semi standard non polar33892256
Fenoldopam,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C(C)(C)C)CCC3=C2C=C(O)C(O[Si](C)(C)C(C)(C)C)=C3Cl)C=C13669.8Semi standard non polar33892256
Fenoldopam,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC1=CC2=C(CCN([Si](C)(C)C(C)(C)C)CC2C2=CC=C(O)C=C2)C(Cl)=C1O[Si](C)(C)C(C)(C)C3715.4Semi standard non polar33892256
Fenoldopam,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C(C)(C)C)CCC3=C2C=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C3Cl)C=C13868.3Semi standard non polar33892256
Fenoldopam,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C(C)(C)C)CCC3=C2C=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C3Cl)C=C13743.5Standard non polar33892256
Fenoldopam,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC1=CC=C(C2CN([Si](C)(C)C(C)(C)C)CCC3=C2C=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C3Cl)C=C13412.4Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (Non-derivatized) - 70eV, Positivesplash10-01t9-0391000000-76fb34f9a9a26d6b44fa2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (3 TMS) - 70eV, Positivesplash10-0aba-2401970000-73047b4dfcaaafe578092017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_3_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_3_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TMS_3_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TBDMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TBDMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TBDMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TBDMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TBDMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Fenoldopam GC-MS (TBDMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Fenoldopam , positive-QTOFsplash10-0a4i-0429000000-b564c6e7915f2c21d65e2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Fenoldopam 35V, Positive-QTOFsplash10-0a4i-0932000000-36040192f388490c28942021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Fenoldopam 35V, Negative-QTOFsplash10-0udi-0009000000-a3c9d39f57ede3fb87532021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 10V, Positive-QTOFsplash10-0a4i-0019000000-38d4bbf63344a33870af2016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 20V, Positive-QTOFsplash10-0a4i-0597000000-3eddf57e3857fb78798a2016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 40V, Positive-QTOFsplash10-014i-1690000000-db191e036303301ef9e12016-08-02Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 10V, Negative-QTOFsplash10-0udi-0009000000-c0b9604707625fc0532a2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 20V, Negative-QTOFsplash10-0udi-0029000000-bf2fa5ca5d4643e1e3932016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 40V, Negative-QTOFsplash10-0006-9050000000-0209a54b80e04e330ca02016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 10V, Positive-QTOFsplash10-0a4i-0029000000-0f08ec911c469a6f223b2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 20V, Positive-QTOFsplash10-0a4i-0029000000-11f25d33ed7394af33b02021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 40V, Positive-QTOFsplash10-05r0-1980000000-3267b8e156f7b79e59462021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 10V, Negative-QTOFsplash10-0udi-0009000000-9eb426379aeb5cbbe7f32021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 20V, Negative-QTOFsplash10-0udi-2019000000-6f182fa06df66c61a0012021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Fenoldopam 40V, Negative-QTOFsplash10-001i-9230000000-935df3216caca6ef8abe2021-10-11Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00800 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00800 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00800
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3224
KEGG Compound IDC07693
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkFenoldopam
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID5002
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular weight:
48956.3
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Martin SW, Broadley KJ: Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade. Br J Pharmacol. 1995 May;115(2):349-55. [PubMed:7670737 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular weight:
49953.1
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Martin SW, Broadley KJ: Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade. Br J Pharmacol. 1995 May;115(2):349-55. [PubMed:7670737 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular weight:
49521.6
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Martin SW, Broadley KJ: Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade. Br J Pharmacol. 1995 May;115(2):349-55. [PubMed:7670737 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Gene Name:
DRD1
Uniprot ID:
P21728
Molecular weight:
49292.8
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Zeng C, Han Y, Huang H, Yu C, Ren H, Shi W, He D, Huang L, Yang C, Wang X, Zhou L, Jose PA: D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression. J Hypertens. 2009 May;27(5):1033-41. doi: 10.1097/HJH.0b013e3283293c7b. [PubMed:19293728 ]
  3. Dhasmana KM, Villalon CM, Zhu YN, Parmar SS: The role of dopamine (D2), alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat. Pharmacol Res. 1993 May-Jun;27(4):335-47. [PubMed:8103596 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Gene Name:
DRD5
Uniprot ID:
P21918
Molecular weight:
52950.5
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Zeng C, Han Y, Huang H, Yu C, Ren H, Shi W, He D, Huang L, Yang C, Wang X, Zhou L, Jose PA: D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression. J Hypertens. 2009 May;27(5):1033-41. doi: 10.1097/HJH.0b013e3283293c7b. [PubMed:19293728 ]
  4. Dhasmana KM, Villalon CM, Zhu YN, Parmar SS: The role of dopamine (D2), alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat. Pharmacol Res. 1993 May-Jun;27(4):335-47. [PubMed:8103596 ]