Hmdb loader
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2022-03-07 02:51:53 UTC
HMDB IDHMDB0015187
Secondary Accession Numbers
  • HMDB15187
Metabolite Identification
Common NameNitrendipine
DescriptionNitrendipine is only found in individuals that have used or taken this drug. It is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. [PubChem]By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Structure
Data?1582753268
Synonyms
ValueSource
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl esterChEBI
BAY e 5009ChEBI
BayotensinChEBI
BaypressChEBI
BylotensinChEBI
DeitenChEBI
NidrelChEBI
NitrendipinoChEBI
NitrendipinumChEBI
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate ethyl methyl esterGenerator
NitrendipinHMDB
Atid, nitrendipinHMDB
Bayer brand OF nitrendipineHMDB
Biomed brand OF nitrendipineHMDB
Docpharm brand OF nitrendipineHMDB
Elfar brand OF nitrendipineHMDB
Hexal brand OF nitrendipineHMDB
JutapressHMDB
Lich, nitrenHMDB
Nitre abzHMDB
Nitren 1a pharmaHMDB
Nitren acisHMDB
Nitrend KSKHMDB
NitrendimerckHMDB
Nitrendipin alHMDB
Nitrendipin atidHMDB
Nitrendipin jenapharmHMDB
Nitrendipine apogepha brandHMDB
Nitrendipine basics brandHMDB
Nitrendipine bayer brandHMDB
Nitrendipine dexcel brandHMDB
Nitrendipine hexal brandHMDB
Nitrendipine jenapharm brandHMDB
Nitrendipine lichtenstein brandHMDB
Nitrendipine Q-pharm brandHMDB
Nitrendipine corax brandHMDB
Nitrendipino ratiopharmHMDB
Pharma, nitren 1aHMDB
Prevision y salud brand OF nitrendipineHMDB
Ratiopharm, nitrendipinoHMDB
Schwarz brand OF nitrendipineHMDB
CT Arzneimittel brand OF nitrendipineHMDB
CT, Nitrendipin vonHMDB
Nitrendipin coraxHMDB
Nitrendipin-coraxHMDB
Von CT, nitrendipinHMDB
Aliud brand OF nitrendipineHMDB
Apogepha, nitrendipinHMDB
BC Brand OF nitrendipineHMDB
Basics brand OF nitrendipineHMDB
Basics, nitrendipinHMDB
Bayvit, nitrendipinoHMDB
Biochemie, nitrendiHMDB
Dexcel brand OF nitrendipineHMDB
GericinHMDB
Jenapharm, nitrendipinHMDB
Juta brand OF nitrendipineHMDB
KSK, NitrendHMDB
Lindo, nitrendipinHMDB
Merck dura brand OF nitrendipineHMDB
NiprinaHMDB
Nitre purenHMDB
Nitren lichHMDB
Nitrendi biochemieHMDB
Nitrendipin lindoHMDB
Nitrendipine 1a brandHMDB
Nitrendipine almirall brandHMDB
Nitrendipine azupharma brandHMDB
Nitrendipine bayvit brandHMDB
Nitrendipine docpharm brandHMDB
Nitrendipine juta brandHMDB
Nitrendipine seid brandHMDB
Nitrendipine stadapharm brandHMDB
Nitrendipine wörwag brandHMDB
Nitrendipine acis brandHMDB
Nitrendipine CT-arzneimittel brandHMDB
NitrepressHMDB
Q-Pharm brand OF nitrendipineHMDB
Wörwag brand OF nitrendipineHMDB
Acis, nitrenHMDB
CT-Arzneimittel brand OF nitrendipineHMDB
Nitrendipin von CTHMDB
AL, nitrendipinHMDB
AbZ brand OF nitrendipineHMDB
AbZ, nitreHMDB
Almirall brand OF nitrendipineHMDB
Alpharma brand OF nitrendipineHMDB
Azupharma brand OF nitrendipineHMDB
BalminilHMDB
BaypresolHMDB
Elan brand OF nitrendipineHMDB
Heumann brand OF nitrendipineHMDB
Heumann, nitrendipinHMDB
Nitre-purenHMDB
NitrePurenHMDB
NitregammaHMDB
Nitrendipin apogephaHMDB
Nitrendipin basicsHMDB
Nitrendipin stadaHMDB
Nitrendipin ratiopharmHMDB
Nitrendipine aliud brandHMDB
Nitrendipine heumann brandHMDB
Nitrendipine lindopharm brandHMDB
Nitrendipine schwarz brandHMDB
Nitrendipine betapharm brandHMDB
NitrensalHMDB
Seid brand OF nitrendipineHMDB
TAD brand OF nitrendipineHMDB
TensogradalHMDB
TrendinolHMDB
VastensiumHMDB
Acis brand OF nitrendipineHMDB
Betapharm brand OF nitrendipineHMDB
1a Brand OF nitrendipineHMDB
1a Pharma, nitrenHMDB
Apogepha brand OF nitrendipineHMDB
Bayvit brand OF nitrendipineHMDB
Jenapharm brand OF nitrendipineHMDB
KSK Pharma brand OF nitrendipineHMDB
Lichtenstein brand OF nitrendipineHMDB
Lindopharm brand OF nitrendipineHMDB
NitrendepatHMDB
NitrendidocHMDB
Nitrendipin heumannHMDB
Nitrendipin betaHMDB
Nitrendipin-ratiopharmHMDB
Nitrendipine abz brandHMDB
Nitrendipine alpharma brandHMDB
Nitrendipine BC brandHMDB
Nitrendipine biomed brandHMDB
Nitrendipine elan brandHMDB
Nitrendipine elfar brandHMDB
Nitrendipine tad brandHMDB
Nitrendipine ratiopharm brandHMDB
Nitrendipino bayvitHMDB
NitrendipinratiopharmHMDB
Stada, nitrendipinHMDB
Stadapharm brand OF nitrendipineHMDB
beta, NitrendipinHMDB
Corax brand OF nitrendipineHMDB
NitrendipincoraxHMDB
Ratiopharm brand OF nitrendipineHMDB
Chemical FormulaC18H20N2O6
Average Molecular Weight360.3612
Monoisotopic Molecular Weight360.132136382
IUPAC Name3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Traditional Namenitrendipine
CAS Registry Number39562-70-4
SMILES
CCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC
InChI Identifier
InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
InChI KeyPVHUJELLJLJGLN-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. Dihydropyridinecarboxylic acids and derivatives are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassHydropyridines
Direct ParentDihydropyridinecarboxylic acids and derivatives
Alternative Parents
Substituents
  • Dihydropyridinecarboxylic acid derivative
  • Nitrobenzene
  • Nitroaromatic compound
  • Monocyclic benzene moiety
  • Dicarboxylic acid or derivatives
  • Benzenoid
  • Methyl ester
  • Enoate ester
  • Alpha,beta-unsaturated carboxylic ester
  • Vinylogous amide
  • Organic nitro compound
  • Carboxylic acid ester
  • C-nitro compound
  • Amino acid or derivatives
  • Azacycle
  • Propargyl-type 1,3-dipolar organic compound
  • Organic 1,3-dipolar compound
  • Carboxylic acid derivative
  • Allyl-type 1,3-dipolar organic compound
  • Secondary aliphatic amine
  • Enamine
  • Organic oxoazanium
  • Secondary amine
  • Organopnictogen compound
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxide
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Organic oxygen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point156 - 160 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.014 g/LNot Available
LogP2.4Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+CBM182.230932474
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.014 g/LALOGPS
logP3.21ALOGPS
logP2.17ChemAxon
logS-4.4ALOGPS
pKa (Strongest Basic)5.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area110.45 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity96.91 m³·mol⁻¹ChemAxon
Polarizability36.25 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+185.21831661259
DarkChem[M-H]-184.45431661259
DeepCCS[M+H]+189.7430932474
DeepCCS[M-H]-186.4830932474
DeepCCS[M-2H]-222.03430932474
DeepCCS[M+Na]+198.20230932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
NitrendipineCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC3868.4Standard polar33892256
NitrendipineCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC2667.3Standard non polar33892256
NitrendipineCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC2876.0Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Nitrendipine,1TMS,isomer #1CCOC(=O)C1=C(C)N([Si](C)(C)C)C(C)=C(C(=O)OC)C1C1=CC=CC([N+](=O)[O-])=C12692.9Semi standard non polar33892256
Nitrendipine,1TMS,isomer #1CCOC(=O)C1=C(C)N([Si](C)(C)C)C(C)=C(C(=O)OC)C1C1=CC=CC([N+](=O)[O-])=C12399.8Standard non polar33892256
Nitrendipine,1TMS,isomer #1CCOC(=O)C1=C(C)N([Si](C)(C)C)C(C)=C(C(=O)OC)C1C1=CC=CC([N+](=O)[O-])=C13567.6Standard polar33892256
Nitrendipine,1TBDMS,isomer #1CCOC(=O)C1=C(C)N([Si](C)(C)C(C)(C)C)C(C)=C(C(=O)OC)C1C1=CC=CC([N+](=O)[O-])=C12913.9Semi standard non polar33892256
Nitrendipine,1TBDMS,isomer #1CCOC(=O)C1=C(C)N([Si](C)(C)C(C)(C)C)C(C)=C(C(=O)OC)C1C1=CC=CC([N+](=O)[O-])=C12644.1Standard non polar33892256
Nitrendipine,1TBDMS,isomer #1CCOC(=O)C1=C(C)N([Si](C)(C)C(C)(C)C)C(C)=C(C(=O)OC)C1C1=CC=CC([N+](=O)[O-])=C13575.6Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Nitrendipine GC-MS (Non-derivatized) - 70eV, Positivesplash10-002r-3098000000-9ec6d59cfe9d975f2d2c2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Nitrendipine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine LC-ESI-qTof , Positive-QTOFsplash10-016r-0159000000-7b0ccf9fb639868092f02017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine LC-ESI-QFT , negative-QTOFsplash10-0ab9-2539000000-3d9a9111a145f234fc242017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine , positive-QTOFsplash10-016r-0159000000-7b0ccf9fb639868092f02017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine LC-ESI-QFT , positive-QTOFsplash10-016r-0159000000-4e10a6643ba97ab23a0f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 40V, Negative-QTOFsplash10-0770-0590000000-e2603511cd80f07d68212021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 20V, Negative-QTOFsplash10-0079-0293000000-b58e56818952f778a8a32021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 30V, Negative-QTOFsplash10-0079-0590000000-43cafd04f767a714317b2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 40V, Positive-QTOFsplash10-0770-0590000000-b977ed95a872975c33142021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 20V, Positive-QTOFsplash10-0079-0293000000-127382367525266f1beb2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 30V, Positive-QTOFsplash10-0079-0590000000-2346e5cc85521749f6e12021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 10V, Positive-QTOFsplash10-016r-0009000000-24c8ce6e9a1db59d8d892021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 35V, Positive-QTOFsplash10-016r-0059000000-2e6d67d253f63df788c92021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 20V, Positive-QTOFsplash10-016r-0009000000-87fc1263cc41265b79512021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 30V, Positive-QTOFsplash10-014i-0079000000-27494f8b80c16921b8082021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 10V, Negative-QTOFsplash10-0a4i-0019000000-e2fa172c2534fe0675e02021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 35V, Negative-QTOFsplash10-00di-4966000000-a19b2f846a90ebf7182a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 35V, Positive-QTOFsplash10-016r-0049000000-7abf2a16c2a710b402332021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 40V, Positive-QTOFsplash10-11r0-0190000000-29b85250ab05fb78f81f2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Nitrendipine 50V, Positive-QTOFsplash10-0r30-0490000000-571b815c95fe43fa80052021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nitrendipine 10V, Positive-QTOFsplash10-03di-0009000000-5e78ea8682912e622d9f2016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nitrendipine 20V, Positive-QTOFsplash10-0a4l-1019000000-7f41d4099c8ca96fd48d2016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nitrendipine 40V, Positive-QTOFsplash10-0297-6197000000-f08bf471769080e6f0632016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nitrendipine 10V, Negative-QTOFsplash10-0a4i-1009000000-4f705aedc222f83389682016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nitrendipine 20V, Negative-QTOFsplash10-0a4i-1009000000-eb8ed51675addbf4b6e72016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Nitrendipine 40V, Negative-QTOFsplash10-0002-9066000000-72f0970b23fcf91f5d242016-08-03Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01054 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01054 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01054
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID4351
KEGG Compound IDC07713
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNitrendipine
METLIN IDNot Available
PubChem Compound4507
PDB IDNot Available
ChEBI ID7582
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Only showing the first 10 proteins. There are 12 proteins in total.

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular weight:
57108.065
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular weight:
57525.03
General function:
Involved in ion channel activity
Specific function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA)
Gene Name:
CACNA1D
Uniprot ID:
Q01668
Molecular weight:
245138.8
References
  1. Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J: Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009 Feb;75(2):407-14. doi: 10.1124/mol.108.049981. Epub 2008 Nov 24. [PubMed:19029287 ]
General function:
Involved in ion channel activity
Specific function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function
Gene Name:
CACNA1C
Uniprot ID:
Q13936
Molecular weight:
248974.1
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
General function:
Involved in metal ion binding
Specific function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling
Gene Name:
CACNA2D1
Uniprot ID:
P54289
Molecular weight:
124566.9
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
General function:
Involved in calcium channel activity
Specific function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis
Gene Name:
CACNA2D2
Uniprot ID:
Q9NY47
Molecular weight:
129875.2
References
  1. Perez-Reyes E, Van Deusen AL, Vitko I: Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther. 2009 Feb;328(2):621-7. doi: 10.1124/jpet.108.145672. Epub 2008 Oct 30. [PubMed:18974361 ]
General function:
Involved in ion channel activity
Specific function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes
Gene Name:
CACNA1H
Uniprot ID:
O95180
Molecular weight:
259160.2
References
  1. Perez-Reyes E, Van Deusen AL, Vitko I: Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther. 2009 Feb;328(2):621-7. doi: 10.1124/jpet.108.145672. Epub 2008 Oct 30. [PubMed:18974361 ]
General function:
Involved in ion channel activity
Specific function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle
Gene Name:
CACNA1S
Uniprot ID:
Q13698
Molecular weight:
212348.1
References
  1. Peterson BZ, Catterall WA: Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol. 2006 Aug;70(2):667-75. Epub 2006 May 4. [PubMed:16675661 ]
General function:
Involved in voltage-gated calcium channel activity
Specific function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting
Gene Name:
CACNB2
Uniprot ID:
Q08289
Molecular weight:
73579.9
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Transporters

General function:
Involved in ATP binding
Specific function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular weight:
141477.3
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]
  2. Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. [PubMed:12128170 ]

Only showing the first 10 proteins. There are 12 proteins in total.