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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2021-09-14 15:15:54 UTC
HMDB IDHMDB0015323
Secondary Accession Numbers
  • HMDB15323
Metabolite Identification
Common NameOxymorphone
DescriptionOxymorphone, also known as numorphan or opana, belongs to the class of organic compounds known as phenanthrenes and derivatives. These are polycyclic compounds containing a phenanthrene moiety, which is a tricyclic aromatic compound with three non-linearly fused benzene. Oxymorphone is a drug which is used for the treatment of moderate-to-severe pain. The amount of transfer of oxymorphone into the breast milk is not known and women are cautioned to weigh the risks and benefits before breastfeeding while on this medication. Oxymorphone is a very strong basic compound (based on its pKa). In humans, oxymorphone is involved in oxymorphone action pathway. Oxymorphone is a potentially toxic compound.
Structure
Data?1582753283
Synonyms
ValueSource
NumorphanHMDB
OpanaHMDB
14-HydroxydihydromorphinoneHMDB
DihydrohydroxymorphinoneHMDB
DihydroxymorphinoneHMDB
EN3202HMDB
OximorphonumHMDB
OxymorphineHMDB
Bristol-myers squibb brand OF oxymorphone hydrochlorideHMDB
Oxymorphone HCLHMDB
endo Brand OF oxymorphone hydrochlorideHMDB
Oxymorphone hydrochlorideHMDB
endo Brand OF oxymorphine HCLHMDB
Chemical FormulaC17H19NO4
Average Molecular Weight301.3371
Monoisotopic Molecular Weight301.131408101
IUPAC Name(1S,5R,13R,17S)-10,17-dihydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-one
Traditional Nameoxymorphone
CAS Registry Number76-41-5
SMILES
[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=O
InChI Identifier
InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1
InChI KeyUQCNKQCJZOAFTQ-ISWURRPUSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phenanthrenes and derivatives. These are polycyclic compounds containing a phenanthrene moiety, which is a tricyclic aromatic compound with three non-linearly fused benzene.
KingdomOrganic compounds
Super ClassBenzenoids
ClassPhenanthrenes and derivatives
Sub ClassNot Available
Direct ParentPhenanthrenes and derivatives
Alternative Parents
Substituents
  • Phenanthrene
  • Isoquinolone
  • Tetralin
  • Coumaran
  • 1-hydroxy-2-unsubstituted benzenoid
  • Alkyl aryl ether
  • Aralkylamine
  • Piperidine
  • Cyclic alcohol
  • Tertiary alcohol
  • 1,2-aminoalcohol
  • Ketone
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ether
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organic nitrogen compound
  • Organopnictogen compound
  • Carbonyl group
  • Organooxygen compound
  • Alcohol
  • Organic oxygen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point248 - 249 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility25.6 g/LNot Available
LogP0Not Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+CBM164.630932474
Predicted Molecular Properties
PropertyValueSource
Water Solubility25.6 g/LALOGPS
logP1.26ALOGPS
logP0.78ChemAxon
logS-1.1ALOGPS
pKa (Strongest Acidic)7.34ChemAxon
pKa (Strongest Basic)10.93ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area70 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity79.56 m³·mol⁻¹ChemAxon
Polarizability30.77 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+169.77131661259
DarkChem[M-H]-163.33131661259
DeepCCS[M-2H]-210.28230932474
DeepCCS[M+Na]+186.22730932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Oxymorphone[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=O3878.8Standard polar33892256
Oxymorphone[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=O2467.8Standard non polar33892256
Oxymorphone[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=O2654.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Oxymorphone,1TMS,isomer #1CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C)=C4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C52620.5Semi standard non polar33892256
Oxymorphone,1TMS,isomer #2CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2C(=O)CC[C@@]3(O[Si](C)(C)C)[C@H]1C52560.0Semi standard non polar33892256
Oxymorphone,1TMS,isomer #3CN1CC[C@]23C4=C(O[Si](C)(C)C)CC[C@@]2(O)[C@H]1CC1=CC=C(O)C(=C13)O42617.8Semi standard non polar33892256
Oxymorphone,1TMS,isomer #4CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2C(O[Si](C)(C)C)=CC[C@@]3(O)[C@H]1C52579.7Semi standard non polar33892256
Oxymorphone,2TMS,isomer #1CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C)=C4O[C@H]2C(=O)CC[C@@]3(O[Si](C)(C)C)[C@H]1C52587.8Semi standard non polar33892256
Oxymorphone,2TMS,isomer #2CN1CC[C@]23C4=C(O[Si](C)(C)C)CC[C@@]2(O)[C@H]1CC1=CC=C(O[Si](C)(C)C)C(=C13)O42622.5Semi standard non polar33892256
Oxymorphone,2TMS,isomer #3CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C)=CC[C@@]3(O)[C@H]1C52582.9Semi standard non polar33892256
Oxymorphone,2TMS,isomer #4CN1CC[C@]23C4=C(O[Si](C)(C)C)CC[C@@]2(O[Si](C)(C)C)[C@H]1CC1=CC=C(O)C(=C13)O42540.8Semi standard non polar33892256
Oxymorphone,2TMS,isomer #5CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2C(O[Si](C)(C)C)=CC[C@@]3(O[Si](C)(C)C)[C@H]1C52534.8Semi standard non polar33892256
Oxymorphone,3TMS,isomer #1CN1CC[C@]23C4=C(O[Si](C)(C)C)CC[C@@]2(O[Si](C)(C)C)[C@H]1CC1=CC=C(O[Si](C)(C)C)C(=C13)O42605.1Semi standard non polar33892256
Oxymorphone,3TMS,isomer #1CN1CC[C@]23C4=C(O[Si](C)(C)C)CC[C@@]2(O[Si](C)(C)C)[C@H]1CC1=CC=C(O[Si](C)(C)C)C(=C13)O42692.6Standard non polar33892256
Oxymorphone,3TMS,isomer #1CN1CC[C@]23C4=C(O[Si](C)(C)C)CC[C@@]2(O[Si](C)(C)C)[C@H]1CC1=CC=C(O[Si](C)(C)C)C(=C13)O43082.5Standard polar33892256
Oxymorphone,3TMS,isomer #2CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C)=CC[C@@]3(O[Si](C)(C)C)[C@H]1C52620.8Semi standard non polar33892256
Oxymorphone,3TMS,isomer #2CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C)=CC[C@@]3(O[Si](C)(C)C)[C@H]1C52650.3Standard non polar33892256
Oxymorphone,3TMS,isomer #2CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C)=CC[C@@]3(O[Si](C)(C)C)[C@H]1C53047.9Standard polar33892256
Oxymorphone,1TBDMS,isomer #1CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C(C)(C)C)=C4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C52902.4Semi standard non polar33892256
Oxymorphone,1TBDMS,isomer #2CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2C(=O)CC[C@@]3(O[Si](C)(C)C(C)(C)C)[C@H]1C52822.0Semi standard non polar33892256
Oxymorphone,1TBDMS,isomer #3CN1CC[C@]23C4=C(O[Si](C)(C)C(C)(C)C)CC[C@@]2(O)[C@H]1CC1=CC=C(O)C(=C13)O42871.6Semi standard non polar33892256
Oxymorphone,1TBDMS,isomer #4CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2C(O[Si](C)(C)C(C)(C)C)=CC[C@@]3(O)[C@H]1C52836.7Semi standard non polar33892256
Oxymorphone,2TBDMS,isomer #1CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C(C)(C)C)=C4O[C@H]2C(=O)CC[C@@]3(O[Si](C)(C)C(C)(C)C)[C@H]1C53058.2Semi standard non polar33892256
Oxymorphone,2TBDMS,isomer #2CN1CC[C@]23C4=C(O[Si](C)(C)C(C)(C)C)CC[C@@]2(O)[C@H]1CC1=CC=C(O[Si](C)(C)C(C)(C)C)C(=C13)O43125.2Semi standard non polar33892256
Oxymorphone,2TBDMS,isomer #3CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C(C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C(C)(C)C)=CC[C@@]3(O)[C@H]1C53084.7Semi standard non polar33892256
Oxymorphone,2TBDMS,isomer #4CN1CC[C@]23C4=C(O[Si](C)(C)C(C)(C)C)CC[C@@]2(O[Si](C)(C)C(C)(C)C)[C@H]1CC1=CC=C(O)C(=C13)O43040.3Semi standard non polar33892256
Oxymorphone,2TBDMS,isomer #5CN1CC[C@]23C4=C5C=CC(O)=C4O[C@H]2C(O[Si](C)(C)C(C)(C)C)=CC[C@@]3(O[Si](C)(C)C(C)(C)C)[C@H]1C53025.2Semi standard non polar33892256
Oxymorphone,3TBDMS,isomer #1CN1CC[C@]23C4=C(O[Si](C)(C)C(C)(C)C)CC[C@@]2(O[Si](C)(C)C(C)(C)C)[C@H]1CC1=CC=C(O[Si](C)(C)C(C)(C)C)C(=C13)O43284.4Semi standard non polar33892256
Oxymorphone,3TBDMS,isomer #1CN1CC[C@]23C4=C(O[Si](C)(C)C(C)(C)C)CC[C@@]2(O[Si](C)(C)C(C)(C)C)[C@H]1CC1=CC=C(O[Si](C)(C)C(C)(C)C)C(=C13)O43345.8Standard non polar33892256
Oxymorphone,3TBDMS,isomer #1CN1CC[C@]23C4=C(O[Si](C)(C)C(C)(C)C)CC[C@@]2(O[Si](C)(C)C(C)(C)C)[C@H]1CC1=CC=C(O[Si](C)(C)C(C)(C)C)C(=C13)O43378.7Standard polar33892256
Oxymorphone,3TBDMS,isomer #2CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C(C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C(C)(C)C)=CC[C@@]3(O[Si](C)(C)C(C)(C)C)[C@H]1C53299.9Semi standard non polar33892256
Oxymorphone,3TBDMS,isomer #2CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C(C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C(C)(C)C)=CC[C@@]3(O[Si](C)(C)C(C)(C)C)[C@H]1C53226.9Standard non polar33892256
Oxymorphone,3TBDMS,isomer #2CN1CC[C@]23C4=C5C=CC(O[Si](C)(C)C(C)(C)C)=C4O[C@H]2C(O[Si](C)(C)C(C)(C)C)=CC[C@@]3(O[Si](C)(C)C(C)(C)C)[C@H]1C53323.8Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Oxymorphone GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4l-9050000000-d955cbd739d3bad187562017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxymorphone GC-MS (2 TMS) - 70eV, Positivesplash10-00c0-6907600000-2e98fd21eb80cd8204b32017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxymorphone GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxymorphone GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
MSMass Spectrum (Electron Ionization)splash10-0udl-7932000000-89141254d526ca629dac2014-09-20Not AvailableView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxymorphone 35V, Positive-QTOFsplash10-0f89-0093000000-d20c48538ad6696fd83b2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 10V, Positive-QTOFsplash10-0f89-0095000000-3fa32e9f5773ea0cc9922016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 20V, Positive-QTOFsplash10-001i-0091000000-4c5b42673e83312d13052016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 40V, Positive-QTOFsplash10-069u-3090000000-b1a88d98c02d968d13322016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 10V, Negative-QTOFsplash10-0udi-0029000000-0f9dac6d2c5bb246b5652016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 20V, Negative-QTOFsplash10-0ue9-0097000000-2bab2cfd5aabe92e0abe2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 40V, Negative-QTOFsplash10-000x-2090000000-7d02b1358307dc0ce4d22016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 10V, Positive-QTOFsplash10-0udi-0009000000-ab6f6c1d45a17ba966cd2021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 20V, Positive-QTOFsplash10-0ue9-0049000000-68376f76c73135dac7e32021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 40V, Positive-QTOFsplash10-0uk9-0093000000-3e6504da4a5c1b25ff702021-10-11Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 10V, Negative-QTOFsplash10-0udi-0009000000-867b26b8e9b8bd5f92732021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 20V, Negative-QTOFsplash10-0udi-0009000000-867b26b8e9b8bd5f92732021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxymorphone 40V, Negative-QTOFsplash10-0udi-0097000000-9087b236d7dbdab76ba52021-10-12Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01192 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01192 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01192
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID4447650
KEGG Compound IDC08019
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkOxymorphone
METLIN IDNot Available
PubChem Compound5284604
PDB IDNot Available
ChEBI ID194484
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Olkkola KT, Laine K: Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87. doi: 10.1111/j.1365-2125.2010.03653.x. [PubMed:20642550 ]
  2. Samer CF, Daali Y, Wagner M, Hopfgartner G, Eap CB, Rebsamen MC, Rossier MF, Hochstrasser D, Dayer P, Desmeules JA: The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone. Br J Pharmacol. 2010 Jun;160(4):907-18. doi: 10.1111/j.1476-5381.2010.00673.x. [PubMed:20590587 ]
  3. Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD: Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther. 2006 May;79(5):461-79. [PubMed:16678548 ]
  4. Adams M, Pieniaszek HJ Jr, Gammaitoni AR, Ahdieh H: Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways. J Clin Pharmacol. 2005 Mar;45(3):337-45. [PubMed:15703368 ]
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular weight:
55768.94
References
  1. Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Olkkola KT, Laine K: Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87. doi: 10.1111/j.1365-2125.2010.03653.x. [PubMed:20642550 ]
  2. Samer CF, Daali Y, Wagner M, Hopfgartner G, Eap CB, Rebsamen MC, Rossier MF, Hochstrasser D, Dayer P, Desmeules JA: The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone. Br J Pharmacol. 2010 Jun;160(4):907-18. doi: 10.1111/j.1476-5381.2010.00673.x. [PubMed:20590587 ]
  3. Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD: Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther. 2006 May;79(5):461-79. [PubMed:16678548 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular weight:
40412.3
References
  1. Chamberlin KW, Cottle M, Neville R, Tan J: Oral oxymorphone for pain management. Ann Pharmacother. 2007 Jul;41(7):1144-52. Epub 2007 Jun 26. [PubMed:17595308 ]
  2. Ananthan S, Khare NK, Saini SK, Seitz LE, Bartlett JL, Davis P, Dersch CM, Porreca F, Rothman RB, Bilsky EJ: Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. J Med Chem. 2004 Mar 11;47(6):1400-12. [PubMed:14998329 ]
General function:
Involved in G-protein coupled receptor protein signaling pathway
Specific function:
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular weight:
44778.9
References
  1. Spetea M, Nevin ST, Hosztafi S, Ronai AZ, Toth G, Borsodi A: Affinity profiles of novel delta-receptor selective benzofuran derivatives of non-peptide opioids. Neurochem Res. 1998 Sep;23(9):1211-6. [PubMed:9712193 ]
  2. Lemberg KK, Kontinen VK, Siiskonen AO, Viljakka KM, Yli-Kauhaluoma JT, Korpi ER, Kalso EA: Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats. Anesthesiology. 2006 Oct;105(4):801-12. [PubMed:17006080 ]
  3. Chamberlin KW, Cottle M, Neville R, Tan J: Oral oxymorphone for pain management. Ann Pharmacother. 2007 Jul;41(7):1144-52. Epub 2007 Jun 26. [PubMed:17595308 ]
  4. Halimi G, Devaux C, Clot-Faybesse O, Sampol J, Legof L, Rochat H, Guieu R: Modulation of adenosine concentration by opioid receptor agonists in rat striatum. Eur J Pharmacol. 2000 Jun 16;398(2):217-24. [PubMed:10854833 ]
  5. Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F: Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neurosci Lett. 2006 Mar 20;396(1):44-9. Epub 2005 Dec 15. [PubMed:16343768 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]