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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:51 UTC
Update Date2022-03-07 02:51:58 UTC
HMDB IDHMDB0015371
Secondary Accession Numbers
  • HMDB15371
Metabolite Identification
Common NameGemfibrozil
DescriptionGemfibrozil, also known as lopid or bolutol, belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. Gemfibrozil is an extremely weak basic (essentially neutral) compound (based on its pKa). Gemfibrozil is a potentially toxic compound. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. IV): Gemfibrozil, though not as effective as niacin, is better tolerated. Statin drugs: Concomitant administration of fibrates (including gemfibrozil) with statin drugs increases the risk of muscle cramping, myopathy, and rhabdomyolysis. Serious side effects may include angioedema, gallstones, liver problems, and muscle breakdown. It is unclear if it changes the risk of heart disease.
Structure
Data?1582753289
Synonyms
ValueSource
2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeureChEBI
2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeureChEBI
2,2-Dimethyl-5-(2,5-xylyloxy)valeric acidChEBI
GemfibroziloChEBI
GemfibrozilumChEBI
LopidChEBI
2,2-Dimethyl-5-(2,5-xylyloxy)valerateGenerator
1a Brand OF gemfibrozilHMDB
Alphapharm brand OF gemfibrozilHMDB
Bayvit, gemfibroziloHMDB
Bexal brand OF gemfibrozilHMDB
Biochemie brand OF gemfibrozilHMDB
BolutolHMDB
Chem mart gemfibrozilHMDB
Farmasierra brand OF gemfibrozilHMDB
Faulding brand OF gemfibrozilHMDB
Gemfibrozil, healthsenseHMDB
GenRX gemfibrozilHMDB
Genpharm brand OF gemfibrozilHMDB
Ipsen brand OF gemfibrozilHMDB
JezilHMDB
Lipox gemfiHMDB
Menarini brand OF gemfibrozilHMDB
Nu-gemfibrozilHMDB
Nu-pharm brand OF gemfibrozilHMDB
PMS-GemfibrozilHMDB
SBPA gemfibrozilHMDB
Sigma brand OF gemfibrozilHMDB
Warner lambert brand OF gemfibrozilHMDB
ApoGemfibrozilHMDB
AusgemHMDB
Bayvit brand OF gemfibrozilHMDB
DBL GemfibrozilHMDB
Douglas brand OF gemfibrozilHMDB
Gemfibrozil, sbpaHMDB
Gemfibrozilo urHMDB
GenGemfibrozilHMDB
LipazilHMDB
Novo-gemfibrozilHMDB
Nu pharm brand OF gemfibrozilHMDB
NuGemfibrozilHMDB
Pharmascience brand OF gemfibrozilHMDB
Apo-gemfibrozilHMDB
Cantabria brand OF gemfibrozilHMDB
Chem mart brand OF gemfibrozilHMDB
GemfibrosilHMDB
Gemfibrozilo bayvitHMDB
Gemfibrozilo bexalHMDB
GemhexalHMDB
Gen gemfibrozilHMDB
Gen-gemfibrozilHMDB
LipurHMDB
Lopid RHMDB
Nu gemfibrozilHMDB
Parke davis brand OF gemfibrozilHMDB
PilderHMDB
Terry white chemists brand OF gemfibrozilHMDB
United drug brand OF gemfibrozilHMDB
Warner-lambert brand OF gemfibrozilHMDB
Apo gemfibrozilHMDB
Apotex brand OF gemfibrozilHMDB
Bull brand OF gemfibrozilHMDB
DecrelipHMDB
Ferrer brand OF gemfibrozilHMDB
Gemfi 1a pharmaHMDB
Gemfibrozil, genrxHMDB
Healthsense brand OF gemfibrozilHMDB
Healthsense gemfibrozilHMDB
Hexal brand OF gemfibrozilHMDB
LitarekHMDB
Novo gemfibrozilHMDB
Novopharm brand OF gemfibrozilHMDB
PMS GemfibrozilHMDB
Pfizer brand OF gemfibrozilHMDB
Quimifar brand OF gemfibrozilHMDB
TAD brand OF gemfibrozilHMDB
Terry white chemists gemfibrozilHMDB
TrialminHMDB
Chemical FormulaC15H22O3
Average Molecular Weight250.3334
Monoisotopic Molecular Weight250.15689457
IUPAC Name5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
Traditional Namegemfibrozil
CAS Registry Number25812-30-0
SMILES
CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1
InChI Identifier
InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChI KeyHEMJJKBWTPKOJG-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassPhenol ethers
Sub ClassNot Available
Direct ParentPhenol ethers
Alternative Parents
Substituents
  • Phenoxy compound
  • P-xylene
  • Xylene
  • Phenol ether
  • Alkyl aryl ether
  • Monocyclic benzene moiety
  • Carboxylic acid derivative
  • Carboxylic acid
  • Ether
  • Monocarboxylic acid or derivatives
  • Organic oxygen compound
  • Organic oxide
  • Carbonyl group
  • Organooxygen compound
  • Hydrocarbon derivative
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point61 - 63 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.028 g/LNot Available
LogP3.4Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.028 g/LALOGPS
logP3.61ALOGPS
logP4.39ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)4.42ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity71.82 m³·mol⁻¹ChemAxon
Polarizability28.9 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+159.66231661259
DarkChem[M-H]-160.04531661259
DeepCCS[M+H]+166.85230932474
DeepCCS[M-H]-164.49430932474
DeepCCS[M-2H]-197.40930932474
DeepCCS[M+Na]+172.94530932474
AllCCS[M+H]+159.232859911
AllCCS[M+H-H2O]+155.832859911
AllCCS[M+NH4]+162.532859911
AllCCS[M+Na]+163.432859911
AllCCS[M-H]-164.532859911
AllCCS[M+Na-2H]-165.032859911
AllCCS[M+HCOO]-165.532859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
GemfibrozilCC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C12901.6Standard polar33892256
GemfibrozilCC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C11917.9Standard non polar33892256
GemfibrozilCC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C11926.6Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Gemfibrozil,1TMS,isomer #1CC1=CC=C(C)C(OCCCC(C)(C)C(=O)O[Si](C)(C)C)=C11912.2Semi standard non polar33892256
Gemfibrozil,1TBDMS,isomer #1CC1=CC=C(C)C(OCCCC(C)(C)C(=O)O[Si](C)(C)C(C)(C)C)=C12156.4Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Gemfibrozil GC-MS (Non-derivatized) - 70eV, Positivesplash10-0076-6950000000-ea8e6e101df62d80313a2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Gemfibrozil GC-MS (1 TMS) - 70eV, Positivesplash10-05g0-9721000000-e7c61af259566e389d952017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Gemfibrozil GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , negative-QTOFsplash10-00di-0900000000-24b892a8bd68bdf9cef62017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , negative-QTOFsplash10-00di-0900000000-7a9eaaae65f0e1efcbc42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , negative-QTOFsplash10-00di-0900000000-12b36ea4be2a1b876c612017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , negative-QTOFsplash10-00di-0900000000-647692900acca2ec24412017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , negative-QTOFsplash10-00di-0900000000-41c8e4e08162dfaf1fc42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , negative-QTOFsplash10-00di-0900000000-28d25da91cc1d391cc842017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-ITFT , negative-QTOFsplash10-00di-0900000000-a08267bdc97edb1a26012017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-ITFT , negative-QTOFsplash10-00di-0900000000-a133a90a69b988c45ffb2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , positive-QTOFsplash10-0059-6910000000-0ad597adcb83e9f4e4ba2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , positive-QTOFsplash10-0059-8900000000-8684ba342d3eb0a7f6022017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , positive-QTOFsplash10-05cr-9400000000-008385b887cc6ac6d7482017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , positive-QTOFsplash10-0ac0-9300000000-74e1b5c007dd49af6a012017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , positive-QTOFsplash10-0ab9-9200000000-cc36aaee7c70d8e92f962017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil LC-ESI-QFT , positive-QTOFsplash10-0a4i-9100000000-ce28ed926945c33079d62017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil 90V, Negative-QTOFsplash10-052g-9400000000-7df8d3b3c3d528585b242021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil 75V, Positive-QTOFsplash10-0ab9-9200000000-a29f6ecb2573b0a724632021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil 90V, Positive-QTOFsplash10-0a4i-9100000000-ce28ed926945c33079d62021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil 10V, Positive-QTOFsplash10-004i-0970000000-b6b747ddc80c5e2778572021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Gemfibrozil 30V, Negative-QTOFsplash10-0002-0390000000-b42eee5672459e8cc06b2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gemfibrozil 10V, Positive-QTOFsplash10-0zfr-0290000000-ed946d5de4de22b6bf202016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gemfibrozil 20V, Positive-QTOFsplash10-0a59-4970000000-01a0d2adb215feef78cc2016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gemfibrozil 40V, Positive-QTOFsplash10-053r-9500000000-f971c24cd2f474fea5a32016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gemfibrozil 10V, Negative-QTOFsplash10-0002-0490000000-2ba2ea9e2ef949ad859b2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gemfibrozil 20V, Negative-QTOFsplash10-00di-1950000000-865193b239a02078f9b62016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Gemfibrozil 40V, Negative-QTOFsplash10-00di-4900000000-adb1ff2509f9361f33fe2016-08-03Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Biological Properties
Cellular Locations
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01241 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB01241 details
Abnormal Concentrations
Not Available
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood0.000 uMAdult (>18 years old)BothNormalPredicted based on drug qualities
Blood0.000 umol/mmol creatinineAdult (>18 years old)BothNormalPredicted based on drug qualities
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB01241
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3345
KEGG Compound IDC07020
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkGemfibrozil
METLIN IDNot Available
PubChem Compound3463
PDB IDNot Available
ChEBI ID5296
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Download (PDF)
General ReferencesNot Available

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular weight:
55627.365
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular weight:
58406.915
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular weight:
55824.275
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in DNA binding
Specific function:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene
Gene Name:
PPARA
Uniprot ID:
Q07869
Molecular weight:
52224.6
References
  1. Clavey V, Copin C, Mariotte MC, Bauge E, Chinetti G, Fruchart J, Fruchart JC, Dallongeville J, Staels B: Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells. Cell Physiol Biochem. 1999;9(3):139-49. [PubMed:10494028 ]
  2. Bosse Y, Pascot A, Dumont M, Brochu M, Prud'homme D, Bergeron J, Despres JP, Vohl MC: Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil. Genet Med. 2002 Jul-Aug;4(4):311-5. [PubMed:12172398 ]
  3. Pahan K, Jana M, Liu X, Taylor BS, Wood C, Fischer SM: Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem. 2002 Nov 29;277(48):45984-91. Epub 2002 Sep 18. [PubMed:12244038 ]
  4. Shoji Y, Sanekata A, Sato M, Imaizumi K: Preparation of antiserum against rat delta6-desaturase and its use to evaluate the desaturase protein levels in rats treated with gemfibrozil, a ligand for peroxisome proliferator-activated receptor alpha. Biosci Biotechnol Biochem. 2003 May;67(5):1177-8. [PubMed:12834305 ]
  5. Rizvi F, Iftikhar M, George JP: Beneficial effects of fish liver preparations of sea bass (Lates calcarifer) versus gemfibrozil in high fat diet-induced lipid-intolerant rats. J Med Food. 2003 Summer;6(2):123-8. [PubMed:12935323 ]

Transporters

General function:
Involved in transporter activity
Specific function:
Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular weight:
76448.0
References
  1. Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. doi: 10.3109/00498250903351013. [PubMed:19919292 ]