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Showing metabocard for Cysteinylglycine (HMDB0000078)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:14:30 UTC
HMDB IDHMDB0000078
Secondary Accession Numbers
  • HMDB00078
  • HMDB0028775
  • HMDB28775
Metabolite Identification
Common NameCysteinylglycine
DescriptionCysteinylglycine is a naturally occurring dipeptide composed of cysteine and glycine. It is derived from the breakdown of glutathione (a tripeptide). In plasma, cysteinylglycine is in a reduced, oxidized, and protein-bound form (aminothiol) and interacts via redox and disulphide exchange reactions in a dynamic system referred to as redox thiol status (PMID: 8642471 ). Spermatozoa of sub-fertile men contain significantly higher thiol concentrations as compared with those of fertile men. The detrimental effect on embryo quality of a high homocysteine (Hcy) concentration in the ejaculate and in the follicular fluid is intriguing and may suggest that Hcy is inversely associated with fertility outcome (PMID: 16556671 ). Rheumatoid arthritis (RA) is a chronic inflammatory disease which involves the synovial membrane of multiple diarthroidal joints causing damage to cartilage and bones. The damage process seems to be related to an overproduction of oxygen reactive species inducing an oxidative perturbation with an increase in some oxidized forms (disulfides and protein mixed disulfides) and a decrease in free thiols (PMID: 15895891 ). Imipenem (thienamycin formamidine) is a broad-spectrum beta-lactam antibiotic, always used in combination with cilastatin in order to avoid the premature breakdown of imipenem by renal tubular dipeptidase. As this dipeptidase also hydrolyzes the glutathione metabolite cysteinylglycine, the therapeutic association of imipenem and cilastatin causes plasma levels of cysteinylglycine to increase significantly, while cysteine levels are decreased and homocysteine levels are unaffected. Therefore, antibiotic treatment using imipenem-cilastatin induces important metabolic changes that should not remain unrecognized (PMID: 15843241 ).
Structure
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MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000078 (Cysteinylglycine)

      Cysteinylglycine.mol
  Mrv1652309032023512D          

 11 10  0  0  0  0            999 V2000
    1.4289    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.2063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.0311    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.2062    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1434   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578    0.2062    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  2  0  0  0  0
  1  5  1  0  0  0  0
  8  7  1  6  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  6 10  2  0  0  0  0
  2  6  1  0  0  0  0
  9 11  1  0  0  0  0
M  END
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3D MOL for HMDB0000078 (Cysteinylglycine)

HMDB0000078
     RDKit          3D
Cysteinylglycine
 21 20  0  0  0  0  0  0  0  0999 V2000
   -2.0359   -0.4967   -0.8655 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5652    0.1748    0.3244 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1381   -0.5702    1.5101 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6405    0.1483    3.0856 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0929    0.1776    0.3540 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5360    0.7059    1.2943 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6224   -0.4283   -0.7008 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0691   -0.4714   -0.7530 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5693    0.9152   -0.7610 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7638    1.8660   -0.7261 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9272    1.1571   -0.8070 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1116   -1.5246   -0.7428 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0268   -0.1604   -1.0291 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9399    1.2352    0.3459 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8741   -1.6336    1.4396 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2516   -0.4730    1.4386 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3625    1.5097    2.9277 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1084   -0.8820   -1.5076 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4230   -0.9608   -1.6881 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4856   -0.9875    0.1423 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5346    0.6986   -1.4998 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  2  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  6
  3 15  1  0
  3 16  1  0
  4 17  1  0
  7 18  1  0
  8 19  1  0
  8 20  1  0
 11 21  1  0
M  END
Download

3D SDF for HMDB0000078 (Cysteinylglycine)

      Cysteinylglycine.mol
  Mrv1652309032023512D          

 11 10  0  0  0  0            999 V2000
    1.4289    0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.2063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.2062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.0311    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.2062    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1434   -0.2063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.0313    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578    0.2062    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  2  3  1  0  0  0  0
  1  3  1  0  0  0  0
  1  4  2  0  0  0  0
  1  5  1  0  0  0  0
  8  7  1  6  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  6 10  2  0  0  0  0
  2  6  1  0  0  0  0
  9 11  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000078

> <DATABASE_NAME>
hmdb

> <SMILES>
N[C@@H](CS)C(=O)NCC(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1

> <INCHI_KEY>
ZUKPVRWZDMRIEO-VKHMYHEASA-N

> <FORMULA>
C5H10N2O3S

> <MOLECULAR_WEIGHT>
178.21

> <EXACT_MASS>
178.041212886

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
21

> <JCHEM_AVERAGE_POLARIZABILITY>
16.967003992118627

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-[(2R)-2-amino-3-sulfanylpropanamido]acetic acid

> <ALOGPS_LOGP>
-2.59

> <JCHEM_LOGP>
-3.900224044778602

> <ALOGPS_LOGS>
-1.46

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
9.981290674103914

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.6045336684101867

> <JCHEM_PKA_STRONGEST_BASIC>
8.075279909891346

> <JCHEM_POLAR_SURFACE_AREA>
92.41999999999999

> <JCHEM_REFRACTIVITY>
41.027100000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.25e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
Cys-Gly

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0000078 (Cysteinylglycine)

HMDB0000078
     RDKit          3D
Cysteinylglycine
 21 20  0  0  0  0  0  0  0  0999 V2000
   -2.0359   -0.4967   -0.8655 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5652    0.1748    0.3244 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1381   -0.5702    1.5101 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6405    0.1483    3.0856 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0929    0.1776    0.3540 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5360    0.7059    1.2943 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6224   -0.4283   -0.7008 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0691   -0.4714   -0.7530 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5693    0.9152   -0.7610 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7638    1.8660   -0.7261 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9272    1.1571   -0.8070 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1116   -1.5246   -0.7428 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0268   -0.1604   -1.0291 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9399    1.2352    0.3459 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8741   -1.6336    1.4396 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2516   -0.4730    1.4386 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3625    1.5097    2.9277 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1084   -0.8820   -1.5076 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4230   -0.9608   -1.6881 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4856   -0.9875    0.1423 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5346    0.6986   -1.4998 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  2  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
  9 11  1  0
  1 12  1  0
  1 13  1  0
  2 14  1  6
  3 15  1  0
  3 16  1  0
  4 17  1  0
  7 18  1  0
  8 19  1  0
  8 20  1  0
 11 21  1  0
M  END
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PDB for HMDB0000078 (Cysteinylglycine)

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    MOLECULE:       Cysteinylglycine.mol                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  C   UNK     0       2.667   0.385   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       0.000   0.385   0.000  0.00  0.00           N+0
HETATM    3  C   UNK     0       1.334  -0.385   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       2.667   1.925   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0       4.001  -0.385   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0      -1.334  -0.385   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0      -2.667   1.925   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0      -2.667   0.385   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -4.001  -0.385   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      -1.334  -1.925   0.000  0.00  0.00           O+0
HETATM   11  S   UNK     0      -5.335   0.385   0.000  0.00  0.00           S+0
CONECT    1    3    4    5                                                  
CONECT    2    3    6                                                       
CONECT    3    2    1                                                       
CONECT    4    1                                                            
CONECT    5    1                                                            
CONECT    6    8   10    2                                                  
CONECT    7    8                                                            
CONECT    8    7    6    9                                                  
CONECT    9    8   11                                                       
CONECT   10    6                                                            
CONECT   11    9                                                            
MASTER        0    0    0    0    0    0    0    0   11    0   20    0
END
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3D PDB for HMDB0000078 (Cysteinylglycine)

COMPND    HMDB0000078
HETATM    1  N1  UNL     1      -2.036  -0.497  -0.866  1.00  0.00           N  
HETATM    2  C1  UNL     1      -1.565   0.175   0.324  1.00  0.00           C  
HETATM    3  C2  UNL     1      -2.138  -0.570   1.510  1.00  0.00           C  
HETATM    4  S1  UNL     1      -1.641   0.148   3.086  1.00  0.00           S  
HETATM    5  C3  UNL     1      -0.093   0.178   0.354  1.00  0.00           C  
HETATM    6  O1  UNL     1       0.536   0.706   1.294  1.00  0.00           O  
HETATM    7  N2  UNL     1       0.622  -0.428  -0.701  1.00  0.00           N  
HETATM    8  C4  UNL     1       2.069  -0.471  -0.753  1.00  0.00           C  
HETATM    9  C5  UNL     1       2.569   0.915  -0.761  1.00  0.00           C  
HETATM   10  O2  UNL     1       1.764   1.866  -0.726  1.00  0.00           O  
HETATM   11  O3  UNL     1       3.927   1.157  -0.807  1.00  0.00           O  
HETATM   12  H1  UNL     1      -2.112  -1.525  -0.743  1.00  0.00           H  
HETATM   13  H2  UNL     1      -3.027  -0.160  -1.029  1.00  0.00           H  
HETATM   14  H3  UNL     1      -1.940   1.235   0.346  1.00  0.00           H  
HETATM   15  H4  UNL     1      -1.874  -1.634   1.440  1.00  0.00           H  
HETATM   16  H5  UNL     1      -3.252  -0.473   1.439  1.00  0.00           H  
HETATM   17  H6  UNL     1      -1.363   1.510   2.928  1.00  0.00           H  
HETATM   18  H7  UNL     1       0.108  -0.882  -1.508  1.00  0.00           H  
HETATM   19  H8  UNL     1       2.423  -0.961  -1.688  1.00  0.00           H  
HETATM   20  H9  UNL     1       2.486  -0.987   0.142  1.00  0.00           H  
HETATM   21  H10 UNL     1       4.535   0.699  -1.500  1.00  0.00           H  
CONECT    1    2   12   13
CONECT    2    3    5   14
CONECT    3    4   15   16
CONECT    4   17
CONECT    5    6    6    7
CONECT    7    8   18
CONECT    8    9   19   20
CONECT    9   10   10   11
CONECT   11   21
END
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SMILES for HMDB0000078 (Cysteinylglycine)

N[C@@H](CS)C(=O)NCC(O)=O
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INCHI for HMDB0000078 (Cysteinylglycine)

InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
CGChEBI
Cys-glyChEBI
N-L-CysteinylglycineChEBI
L-CysteinylglycineKegg
N-Cysteinyl glycineHMDB
N-Cysteinyl-glycineHMDB
N-L-Cysteinyl-glycineHMDB
Cysteinyl-glycineHMDB
C-g DipeptideHMDB
CG DipeptideHMDB
Cysteine glycine dipeptideHMDB
Cysteine-glycine dipeptideHMDB
L-Cys-glyHMDB
N-CysteinylglycineHMDB
CysteinylglycineChEBI
Chemical FormulaC5H10N2O3S
Average Molecular Weight178.21
Monoisotopic Molecular Weight178.041212886
IUPAC Name2-[(2R)-2-amino-3-sulfanylpropanamido]acetic acid
Traditional NameCys-Gly
CAS Registry Number19246-18-5
SMILES
N[C@@H](CS)C(=O)NCC(O)=O
InChI Identifier
InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1
InChI KeyZUKPVRWZDMRIEO-VKHMYHEASA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentDipeptides
Alternative Parents
Substituents
  • Alpha-dipeptide
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • Cysteine or derivatives
  • Alpha-amino acid or derivatives
  • Amino acid or derivatives
  • Amino acid
  • Carboxamide group
  • Secondary carboxylic acid amide
  • Alkylthiol
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Organosulfur compound
  • Primary aliphatic amine
  • Primary amine
  • Hydrocarbon derivative
  • Carbonyl group
  • Organic oxide
  • Amine
  • Organopnictogen compound
  • Organic oxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Industrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-MetCCS_train_neg131.77430932474
[M-H]-Not Available131.774http://allccs.zhulab.cn/database/detail?ID=AllCCS00000005
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Saliva
  • Urine
Tissue Locations
  • Placenta
Pathways
Normal Concentrations
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified6.0 (2.0-10.0) uMAdult (>18 years old)BothPhenylketonuria details
Associated Disorders and Diseases
Disease References
Phenylketonuria
  1. Perry TL, Hansen S: Cystinylglycine in plasma: diagnostic relevance for pyroglutamic acidemia, homocystinuria, and phenylketonuria. Clin Chim Acta. 1981 Nov 25;117(1):7-12. [PubMed:7333014 ]
Associated OMIM IDs
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB021891
KNApSAcK IDNot Available
Chemspider ID388596
KEGG Compound IDC01419
BioCyc IDCYS-GLY
BiGG ID1445980
Wikipedia LinkNot Available
METLIN ID5134
PubChem Compound439498
PDB IDNot Available
ChEBI ID4047
Food Biomarker OntologyNot Available
VMH IDCGLY
MarkerDB IDMDB00000042
Good Scents IDNot Available
References
Synthesis ReferenceHolleman, James W. Synthesis of glutathione and cysteinylglycine by soluble enzymes of rat liver. Compt. rend. (1954), 238 1360-1.
Material Safety Data Sheet (MSDS)Not Available
General References

Enzymes

Enzyme Details
1. Aminopeptidase N
General function:
Involved in proteolysis
Specific function:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Gene Name:
ANPEP
Uniprot ID:
P15144
Molecular weight:
Not Available
Reactions
Cysteinylglycine + Water → L-Cysteine + Glycinedetails
Enzyme Details
2. Gamma-glutamyltranspeptidase 1
General function:
Involved in gamma-glutamyltransferase activity
Specific function:
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.
Gene Name:
GGT1
Uniprot ID:
P19440
Molecular weight:
61409.67
Reactions
Glutathione + Water → Cysteinylglycine + Glutamic aciddetails
Glutathione + L-Amino acid → Cysteinylglycine + (5-L-Glutamyl)-L-amino aciddetails
Enzyme Details
3. Gamma-glutamyltransferase 7
General function:
Involved in gamma-glutamyltransferase activity
Specific function:
Cleaves glutathione conjugates (By similarity).
Gene Name:
GGT7
Uniprot ID:
Q9UJ14
Molecular weight:
70466.015
Reactions
Glutathione + Water → Cysteinylglycine + Glutamic aciddetails
Glutathione + L-Amino acid → Cysteinylglycine + (5-L-Glutamyl)-L-amino aciddetails
Enzyme Details
4. Cytosol aminopeptidase
General function:
Involved in aminopeptidase activity
Specific function:
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Gene Name:
LAP3
Uniprot ID:
P28838
Molecular weight:
Not Available
Reactions
Cysteinylglycine + Water → L-Cysteine + Glycinedetails
Enzyme Details
5. Gamma-glutamyltransferase 6
General function:
Involved in gamma-glutamyltransferase activity
Specific function:
Cleaves glutathione conjugates (By similarity).
Gene Name:
GGT6
Uniprot ID:
Q6P531
Molecular weight:
50508.83
Reactions
Glutathione + Water → Cysteinylglycine + Glutamic aciddetails
Glutathione + L-Amino acid → Cysteinylglycine + (5-L-Glutamyl)-L-amino aciddetails
Enzyme Details
6. GGT7 protein
General function:
Involved in gamma-glutamyltransferase activity
Specific function:
Not Available
Gene Name:
GGT7
Uniprot ID:
A0PJJ9
Molecular weight:
62565.3
Enzyme Details
7. Gamma-glutamyltransferase 5
General function:
Involved in gamma-glutamyltransferase activity
Specific function:
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
Gene Name:
GGT5
Uniprot ID:
P36269
Molecular weight:
62331.75
Reactions
Glutathione + Water → Cysteinylglycine + Glutamic aciddetails
Glutathione + L-Amino acid → Cysteinylglycine + (5-L-Glutamyl)-L-amino aciddetails
Enzyme Details
8. Gamma-glutamyltranspeptidase 2
General function:
Not Available
Specific function:
Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity).
Gene Name:
GGT2
Uniprot ID:
P36268
Molecular weight:
Not Available
Reactions
Glutathione + Water → Cysteinylglycine + Glutamic aciddetails
Enzyme Details
9. Putative gamma-glutamyltranspeptidase 3
General function:
Not Available
Specific function:
Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity).
Gene Name:
GGT3P
Uniprot ID:
A6NGU5
Molecular weight:
Not Available
Reactions
Glutathione + Water → Cysteinylglycine + Glutamic aciddetails