Hmdb loader
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 21:03:55 UTC
Update Date2021-09-14 15:36:53 UTC
HMDB IDHMDB0029157
Secondary Accession Numbers
  • HMDB29157
Metabolite Identification
Common Namegamma-Glutamylproline
Descriptiongamma-Glutamylproline is a dipeptide composed of gamma-glutamate and proline, and is a proteolytic breakdown product of larger proteins. It belongs to the family of N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. gamma-Glutamylproline is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. gamma-Glutamylproline is a biomarker for the consumption of beer.
Structure
Data?1582753382
Synonyms
ValueSource
g-GlutamylprolineGenerator
Γ-glutamylprolineGenerator
gamma-Glutamate proline dipeptideHMDB
gamma-Glutamate-proline dipeptideHMDB
GE-p dipeptideHMDB
GEP dipeptideHMDB
GGlu-proHMDB
L-gamma-Glutamyl-L-prolineHMDB
Γ-glu-proHMDB
Γ-L-glu-L-proHMDB
Γ-L-glutamyl-L-prolineHMDB
L-Γ-glutamyl-L-prolineHMDB
gamma-Glu-proHMDB
gamma-L-Glu-L-proHMDB
gamma-L-Glutamyl-L-prolineHMDB
(2S)-1-[(4S)-4-Amino-4-carboxybutanoyl]pyrrolidine-2-carboxylateHMDB
gamma-GlutamylprolineHMDB
Chemical FormulaC10H16N2O5
Average Molecular Weight244.247
Monoisotopic Molecular Weight244.105921623
IUPAC Name(2S)-1-[(4S)-4-amino-4-carboxybutanoyl]pyrrolidine-2-carboxylic acid
Traditional Name(2S)-1-[(4S)-4-amino-4-carboxybutanoyl]pyrrolidine-2-carboxylic acid
CAS Registry Number53411-63-5
SMILES
N[C@@H](CCC(=O)N1CCC[C@H]1C(O)=O)C(O)=O
InChI Identifier
InChI=1S/C10H16N2O5/c11-6(9(14)15)3-4-8(13)12-5-1-2-7(12)10(16)17/h6-7H,1-5,11H2,(H,14,15)(H,16,17)/t6-,7-/m0/s1
InChI KeyVBCZKAGVUKCANO-BQBZGAKWSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentDipeptides
Alternative Parents
Substituents
  • Alpha-dipeptide
  • Gamma-glutamyl alpha-amino acid
  • Glutamine or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-l-alpha-amino acid
  • Proline or derivatives
  • Alpha-amino acid or derivatives
  • L-alpha-amino acid
  • Alpha-amino acid
  • N-acylpyrrolidine
  • Pyrrolidine carboxylic acid
  • Pyrrolidine carboxylic acid or derivatives
  • Heterocyclic fatty acid
  • Dicarboxylic acid or derivatives
  • Fatty acyl
  • Fatty acid
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Amino acid
  • Amino acid or derivatives
  • Carboxamide group
  • Organoheterocyclic compound
  • Carboxylic acid
  • Azacycle
  • Amine
  • Primary aliphatic amine
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Organonitrogen compound
  • Organooxygen compound
  • Organic oxygen compound
  • Primary amine
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-4.4Extrapolated
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility21.9 g/LALOGPS
logP-3.2ALOGPS
logP-3.5ChemAxon
logS-0.93ALOGPS
pKa (Strongest Acidic)1.96ChemAxon
pKa (Strongest Basic)9.31ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area120.93 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity56.27 m³·mol⁻¹ChemAxon
Polarizability23.84 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+154.98730932474
DeepCCS[M-H]-152.62930932474
DeepCCS[M-2H]-185.57130932474
DeepCCS[M+Na]+161.0830932474
AllCCS[M+H]+152.832859911
AllCCS[M+H-H2O]+149.432859911
AllCCS[M+NH4]+156.032859911
AllCCS[M+Na]+156.932859911
AllCCS[M-H]-153.732859911
AllCCS[M+Na-2H]-153.932859911
AllCCS[M+HCOO]-154.132859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
gamma-GlutamylprolineN[C@@H](CCC(=O)N1CCC[C@H]1C(O)=O)C(O)=O3204.6Standard polar33892256
gamma-GlutamylprolineN[C@@H](CCC(=O)N1CCC[C@H]1C(O)=O)C(O)=O2194.3Standard non polar33892256
gamma-GlutamylprolineN[C@@H](CCC(=O)N1CCC[C@H]1C(O)=O)C(O)=O2480.4Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
gamma-Glutamylproline,1TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@H](N)C(=O)O2232.7Semi standard non polar33892256
gamma-Glutamylproline,1TMS,isomer #2C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N1CCC[C@H]1C(=O)O2204.9Semi standard non polar33892256
gamma-Glutamylproline,1TMS,isomer #3C[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O)C(=O)O2245.8Semi standard non polar33892256
gamma-Glutamylproline,2TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C2243.2Semi standard non polar33892256
gamma-Glutamylproline,2TMS,isomer #2C[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C)C(=O)O2265.1Semi standard non polar33892256
gamma-Glutamylproline,2TMS,isomer #3C[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O)C(=O)O[Si](C)(C)C2241.6Semi standard non polar33892256
gamma-Glutamylproline,2TMS,isomer #4C[Si](C)(C)N([C@@H](CCC(=O)N1CCC[C@H]1C(=O)O)C(=O)O)[Si](C)(C)C2317.2Semi standard non polar33892256
gamma-Glutamylproline,3TMS,isomer #1C[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C2272.4Semi standard non polar33892256
gamma-Glutamylproline,3TMS,isomer #1C[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C2326.9Standard non polar33892256
gamma-Glutamylproline,3TMS,isomer #2C[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2385.5Semi standard non polar33892256
gamma-Glutamylproline,3TMS,isomer #2C[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2386.9Standard non polar33892256
gamma-Glutamylproline,3TMS,isomer #3C[Si](C)(C)OC(=O)[C@H](CCC(=O)N1CCC[C@H]1C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2370.9Semi standard non polar33892256
gamma-Glutamylproline,3TMS,isomer #3C[Si](C)(C)OC(=O)[C@H](CCC(=O)N1CCC[C@H]1C(=O)O)N([Si](C)(C)C)[Si](C)(C)C2374.5Standard non polar33892256
gamma-Glutamylproline,4TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2447.5Semi standard non polar33892256
gamma-Glutamylproline,4TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C2418.5Standard non polar33892256
gamma-Glutamylproline,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@H](N)C(=O)O2474.4Semi standard non polar33892256
gamma-Glutamylproline,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N1CCC[C@H]1C(=O)O2455.7Semi standard non polar33892256
gamma-Glutamylproline,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O)C(=O)O2486.1Semi standard non polar33892256
gamma-Glutamylproline,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C(C)(C)C2693.6Semi standard non polar33892256
gamma-Glutamylproline,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O2729.9Semi standard non polar33892256
gamma-Glutamylproline,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O)C(=O)O[Si](C)(C)C(C)(C)C2704.6Semi standard non polar33892256
gamma-Glutamylproline,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)N([C@@H](CCC(=O)N1CCC[C@H]1C(=O)O)C(=O)O)[Si](C)(C)C(C)(C)C2802.6Semi standard non polar33892256
gamma-Glutamylproline,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2959.9Semi standard non polar33892256
gamma-Glutamylproline,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N1CCC[C@H]1C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2901.6Standard non polar33892256
gamma-Glutamylproline,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3060.2Semi standard non polar33892256
gamma-Glutamylproline,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2966.7Standard non polar33892256
gamma-Glutamylproline,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@H](CCC(=O)N1CCC[C@H]1C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3055.6Semi standard non polar33892256
gamma-Glutamylproline,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@H](CCC(=O)N1CCC[C@H]1C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2974.4Standard non polar33892256
gamma-Glutamylproline,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3316.9Semi standard non polar33892256
gamma-Glutamylproline,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H]1CCCN1C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C3156.2Standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - gamma-Glutamylproline GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 10V, Positive-QTOFsplash10-002b-0980000000-8a1cd401fdb5e05dd9c82019-02-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 20V, Positive-QTOFsplash10-000t-2910000000-b827663230992302012d2019-02-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 40V, Positive-QTOFsplash10-066r-9400000000-fbe9d16e1bcb25bc23142019-02-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 10V, Negative-QTOFsplash10-0007-0690000000-4f6df51ff93ddee6f5c72019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 20V, Negative-QTOFsplash10-0032-2930000000-e0c1993d7d7ea27205762019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 40V, Negative-QTOFsplash10-02ml-9400000000-20d089c4dc42b36eee9e2019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 10V, Negative-QTOFsplash10-01t9-0790000000-b918b6e73b394134ef362021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 20V, Negative-QTOFsplash10-03di-2910000000-b6e1f2141ad7e06531262021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 40V, Negative-QTOFsplash10-03dm-9500000000-3f3c6b45a991e59711122021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 10V, Positive-QTOFsplash10-00kb-4980000000-a28aaafe8c838eb132252021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 20V, Positive-QTOFsplash10-00sj-9800000000-07e1a802fb693b8878352021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - gamma-Glutamylproline 40V, Positive-QTOFsplash10-05gi-9200000000-cb00f3642cff0cc1c1c52021-09-24Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB112149
KNApSAcK IDNot Available
Chemspider ID8031942
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound9856242
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available