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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2017-09-09 08:21:10 UTC
Update Date2022-11-30 19:26:38 UTC
HMDB IDHMDB0116508
Secondary Accession NumbersNone
Metabolite Identification
Common NamePGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z))
DescriptionPGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) is a phosphatidylglycerophosphate (PGP). It is a glycerophospholipid in which a phosphoglycerol moiety occupies a glycerol substitution site followed by another phosphate moiety. Phosphatidylglycerolphosphate is present at a level of 1-2% in most animal tissues, but it can be the second most abundant phospholipid in lung surfactant (up to 11% of the total). It is well established that the concentration of phosphatidylglycerolphosphate increases during fetal development. Phosphatidylglycerolphosphate may be present in animal tissues merely as a precursor for cardiolipin synthesis. As is the case with diacylglycerols, phosphatidylglycerophosphates can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)), in particular, consists of one chain of docosahexaenoic acid at the C-1 position and one chain of cis-vaccenic acid at the C-2 position. They are synthesized by the addition of glycerol 3-phosphate to a CDP-diacylglycerol. In turn, PGPs are dephosphorylated to phosphatidylglycerols (PGs). While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes.
Structure
Data?1563873725
Synonyms
ValueSource
1-docosahexaenoyl-2-cis-vaccenoyl-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) SMPDB, HMDB
PGP(22:6/18:1) SMPDB, HMDB
PGP(22:6n3/18:1n7) SMPDB, HMDB
PGP(22:6w3/18:1w7) SMPDB, HMDB
PGP(40:7)SMPDB, HMDB
PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z))SMPDB
1-docosahexaenoyl-2-vaccenoyl-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate)Lipid Annotator, HMDB
3-sn-phosphatidyl-1'-sn-glycerol 3'-phosphoric acidLipid Annotator, HMDB
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-2-(11Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate)Lipid Annotator, HMDB
PGP(22:6/18:1)Lipid Annotator
[(2S)-3-({[(2R)-3-[(7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy]-2-[(11Z)-octadec-11-enoyloxy]propoxy](hydroxy)phosphoryl}oxy)-2-hydroxypropoxy]phosphonateGenerator, HMDB
Chemical FormulaC46H78O13P2
Average Molecular Weight901.065
Monoisotopic Molecular Weight900.491766568
IUPAC Name[(2S)-3-({[(2R)-3-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy]-2-[(11Z)-octadec-11-enoyloxy]propoxy](hydroxy)phosphoryl}oxy)-2-hydroxypropoxy]phosphonic acid
Traditional Name(2S)-3-{[(2R)-3-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy]-2-[(11Z)-octadec-11-enoyloxy]propoxy(hydroxy)phosphoryl]oxy}-2-hydroxypropoxyphosphonic acid
CAS Registry NumberNot Available
SMILES
[H][C@](O)(COP(O)(O)=O)COP(O)(=O)OC[C@@]([H])(COC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)OC(=O)CCCCCCCCC\C=C/CCCCCC
InChI Identifier
InChI=1S/C46H78O13P2/c1-3-5-7-9-11-13-15-17-19-20-21-22-24-25-27-29-31-33-35-37-45(48)55-41-44(42-58-61(53,54)57-40-43(47)39-56-60(50,51)52)59-46(49)38-36-34-32-30-28-26-23-18-16-14-12-10-8-6-4-2/h5,7,11,13-14,16-17,19,21-22,25,27,31,33,43-44,47H,3-4,6,8-10,12,15,18,20,23-24,26,28-30,32,34-42H2,1-2H3,(H,53,54)(H2,50,51,52)/b7-5-,13-11-,16-14-,19-17-,22-21-,27-25-,33-31-/t43-,44+/m0/s1
InChI KeyOKIXLWJAVIWEHV-JZWMAQNHSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phosphatidylglycerophosphates. These are glycerophosphoglycerophosphates in which two fatty acids are bonded to the 1-glycerol moiety through ester linkages.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphoglycerophosphates
Direct ParentPhosphatidylglycerophosphates
Alternative Parents
Substituents
  • Diacylglycerophosphoglycerophosphate
  • Sn-glycerol-3-phosphate
  • Fatty acid ester
  • Monoalkyl phosphate
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • Secondary alcohol
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organooxygen compound
  • Organic oxide
  • Organic oxygen compound
  • Alcohol
  • Carbonyl group
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
DispositionNot Available
Process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP7.6ALOGPS
logP11.84ChemAxon
logS-6.1ALOGPS
pKa (Strongest Acidic)1.35ChemAxon
pKa (Strongest Basic)-3.4ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area195.35 ŲChemAxon
Rotatable Bond Count43ChemAxon
Refractivity250.81 m³·mol⁻¹ChemAxon
Polarizability100.55 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+287.9330932474
DeepCCS[M-H]-286.03530932474
DeepCCS[M-2H]-319.44530932474
DeepCCS[M+Na]+293.70930932474
AllCCS[M+H]+302.932859911
AllCCS[M+H-H2O]+303.032859911
AllCCS[M+NH4]+302.832859911
AllCCS[M+Na]+302.832859911
AllCCS[M-H]-302.032859911
AllCCS[M+Na-2H]-309.432859911
AllCCS[M+HCOO]-317.532859911

Predicted Kovats Retention Indices

Not Available
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-13Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 10V, Positive-QTOFsplash10-0i0r-1394035163-3eb6dce9e9d30d8748242019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 20V, Positive-QTOFsplash10-07w9-3395013230-85b891159b660e9829502019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 40V, Positive-QTOFsplash10-0a4r-9376014410-2384b4de773d7c0a7f102019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 10V, Negative-QTOFsplash10-004i-5069002130-9b0212f51a13697f00882019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 20V, Negative-QTOFsplash10-004i-9023000000-6d5580159547de08e4e52019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 40V, Negative-QTOFsplash10-004i-9000000000-5956c8dbec1abbd7be382019-02-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 10V, Negative-QTOFsplash10-0002-0010000090-b2414b5eca306d5fd9162021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 20V, Negative-QTOFsplash10-0002-4091044040-988caaac4a6d34f3c4a62021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 40V, Negative-QTOFsplash10-0udi-3092214000-5a8821f1117c9851b9592021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 10V, Positive-QTOFsplash10-0udj-3000015976-198420580669cd5b41622021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 20V, Positive-QTOFsplash10-0k92-2310006920-7b32d69b1cc0b55d3f3d2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PGP(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z)) 40V, Positive-QTOFsplash10-0ufs-0195100000-726b3702222e835547a92021-09-25Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound131823163
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available