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Record Information
Version4.0
StatusDetected but not Quantified
Creation Date2020-10-19 16:14:20 UTC
Update Date2020-10-19 16:40:00 UTC
HMDB IDHMDB0240689
Secondary Accession NumbersNone
Metabolite Identification
Common NameN2-Methyl-L-lysine
DescriptionN2-Methyl-L-lysine, also known as N(a)-methyl-L-lysine, belongs to the class of organic compounds known as l-alpha-amino acids. Lysine methylation displays the highest degree of complexity among known covalent histone modifications, with each site of methylation regulating the association of different effector molecules. The versatility of lysine methylation marks is perhaps best exemplified by modifications implicated in transcriptional regulation as well as being required for double-strand break repair in several organisms. Identification of the numerous biological functions encoded by histone lysine methylation is a major area of research interest. (PMID: 32119527 )
Structure
Thumb
SynonymsNot Available
Chemical FormulaC7H16N2O2
Average Molecular Weight160.217
Monoisotopic Molecular Weight160.121177763
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry NumberNot Available
SMILES
CN[C@@H](CCCCN)C(O)=O
InChI Identifier
InChI=1S/C7H16N2O2/c1-9-6(7(10)11)4-2-3-5-8/h6,9H,2-5,8H2,1H3,(H,10,11)/t6-/m0/s1
InChI KeyOLYPWXRMOFUVGH-LURJTMIESA-N
Chemical Taxonomy
ClassificationNot classified
Ontology
Not Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
Spectra
Not Available
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
External LinksNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Mamani-Huanca M, Gradillas A, Gil de la Fuente A, Lopez-Gonzalvez A, Barbas C: Unveiling the Fragmentation Mechanisms of Modified Amino Acids as the Key for Their Targeted Identification. Anal Chem. 2020 Apr 7;92(7):4848-4857. doi: 10.1021/acs.analchem.9b04313. Epub 2020 Mar 12. [PubMed:32119527 ]