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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2021-09-11 08:06:44 UTC
Update Date2021-09-26 23:02:41 UTC
HMDB IDHMDB0250954
Secondary Accession NumbersNone
Metabolite Identification
Common NameDehydroevodiamine
DescriptionDehydroevodiamine belongs to the class of organic compounds known as quinazolines. Quinazolines are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring. Dehydroevodiamine is a very strong basic compound (based on its pKa). This compound has been identified in human blood as reported by (PMID: 31557052 ). Dehydroevodiamine is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically Dehydroevodiamine is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.
Structure
Thumb
Synonyms
ValueSource
Dehydroevodiamine chlorideMeSH
Chemical FormulaC19H15N3O
Average Molecular Weight301.349
Monoisotopic Molecular Weight301.121512115
IUPAC Name21-methyl-3,13,21-triazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1,3,5,7,9,15,17,19-octaen-14-one
Traditional Name21-methyl-3,13,21-triazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1,3,5,7,9,15,17,19-octaen-14-one
CAS Registry NumberNot Available
SMILES
CN1C2=CC=CC=C2C(=O)N2CCC3=C4C=CC=CC4=NC3=C12
InChI Identifier
InChI=1S/C19H15N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9H,10-11H2,1H3
InChI KeyVXHNSVKJHXSKKM-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as quinazolines. Quinazolines are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazanaphthalenes
Sub ClassBenzodiazines
Direct ParentQuinazolines
Alternative Parents
Substituents
  • Quinazoline
  • Indole or derivatives
  • Tetrahydropyridine
  • Benzenoid
  • Tertiary carboxylic acid amide
  • Vinylogous amide
  • Lactam
  • Carboxamide group
  • Carboxylic acid derivative
  • Azacycle
  • Hydrocarbon derivative
  • Organic oxide
  • Amine
  • Organic oxygen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organic nitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Ontology
Physiological effectNot Available
Disposition
ProcessNot Available
RoleNot Available
Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP2.27ALOGPS
logP2.47ChemAxon
logS-3.1ALOGPS
pKa (Strongest Basic)9.35ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area35.91 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity104.38 m³·mol⁻¹ChemAxon
Polarizability33.59 ųChemAxon
Number of Rings5ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M-2H]-197.01930932474
DeepCCS[M+Na]+172.33830932474
AllCCS[M+H]+170.632859911
AllCCS[M+H-H2O]+167.132859911
AllCCS[M+NH4]+173.832859911
AllCCS[M+Na]+174.732859911
AllCCS[M-H]-177.732859911
AllCCS[M+Na-2H]-176.732859911
AllCCS[M+HCOO]-175.732859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
DehydroevodiamineCN1C2=CC=CC=C2C(=O)N2CCC3=C4C=CC=CC4=NC3=C124377.8Standard polar33892256
DehydroevodiamineCN1C2=CC=CC=C2C(=O)N2CCC3=C4C=CC=CC4=NC3=C123144.2Standard non polar33892256
DehydroevodiamineCN1C2=CC=CC=C2C(=O)N2CCC3=C4C=CC=CC4=NC3=C123175.7Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Dehydroevodiamine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-0930000000-f02ce6072c35f62eaf802021-09-23Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Dehydroevodiamine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dehydroevodiamine 10V, Positive-QTOFsplash10-0udi-0009000000-d645036ef0d7f853d13e2021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dehydroevodiamine 20V, Positive-QTOFsplash10-0udi-0009000000-860b0bd07d29fa07afd62021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dehydroevodiamine 40V, Positive-QTOFsplash10-05i0-5953000000-0fce8180c08f97dbf6312021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dehydroevodiamine 10V, Negative-QTOFsplash10-0udi-0009000000-894637a6c02101f36b982021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dehydroevodiamine 20V, Negative-QTOFsplash10-0udi-0029000000-6cfd1771131ae83e005b2021-10-12Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Dehydroevodiamine 40V, Negative-QTOFsplash10-006y-1960000000-aef40deec67f9ffef4402021-10-12Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound9817839
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Barupal DK, Fiehn O: Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. Environ Health Perspect. 2019 Sep;127(9):97008. doi: 10.1289/EHP4713. Epub 2019 Sep 26. [PubMed:31557052 ]