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Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2021-09-11 20:49:27 UTC
Update Date2021-10-01 23:41:23 UTC
HMDB IDHMDB0258952
Secondary Accession NumbersNone
Metabolite Identification
Common NameTGF-beta
DescriptionBased on a literature review very few articles have been published on 4-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-amino-1-hydroxy-4-(methylsulfanyl)butylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxy-4-(C-hydroxycarbonimidoyl)butylidene]amino}-1,3-dihydroxypropylidene)amino]-1-hydroxypropylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1,3-dihydroxybutylidene}amino)-4-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[({[1-({1-[(1-{[1-({1-[(1-{2-[(1-{[1-({1-[(1-{[1-({4-carbamimidamido-1-[(1-{[1-(2-{2-[(4-carbamimidamido-1-{[1-({4-carbamimidamido-1-[(1-{[4-carbamimidamido-1-({1-[(1-carboxy-3-methylbutyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-hydroxyethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-3-carboxypropyl]-C-hydroxycarbonimidoyl}butyl)-C-hydroxycarbonimidoyl]pyrrolidine-1-carbonyl}pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-2-phenylethyl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)-2-(C-hydroxycarbonimidoyl)ethyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]pyrrolidin-1-yl}-1-oxopropan-2-yl)-C-hydroxycarbonimidoyl]-2-phenylethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]-2-(4-hydroxyphenyl)ethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-(C-hydroxycarbonimidoyl)ethyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)-2-hydroxypropyl]-C-hydroxycarbonimidoyl}butanoic acid. This compound has been identified in human blood as reported by (PMID: 31557052 ). Tgf-beta is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically TGF-beta is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.
Structure
Thumb
Synonyms
ValueSource
4-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-amino-1-hydroxy-4-(methylsulfanyl)butylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxy-4-(C-hydroxycarbonimidoyl)butylidene]amino}-1,3-dihydroxypropylidene)amino]-1-hydroxypropylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1,3-dihydroxybutylidene}amino)-4-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[({[1-({1-[(1-{[1-({1-[(1-{2-[(1-{[1-({1-[(1-{[1-({4-carbamimidamido-1-[(1-{[1-(2-{2-[(4-carbamimidamido-1-{[1-({4-carbamimidamido-1-[(1-{[4-carbamimidamido-1-({1-[(1-carboxy-3-methylbutyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-hydroxyethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-3-carboxypropyl]-C-hydroxycarbonimidoyl}butyl)-C-hydroxycarbonimidoyl]pyrrolidine-1-carbonyl}pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-2-phenylethyl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)-2-(C-hydroxycarbonimidoyl)ethyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]pyrrolidin-1-yl}-1-oxopropan-2-yl)-C-hydroxycarbonimidoyl]-2-phenylethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]-2-(4-hydroxyphenyl)ethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-(C-hydroxycarbonimidoyl)ethyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)-2-hydroxypropyl]-C-hydroxycarbonimidoyl}butanoateGenerator
4-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-amino-1-hydroxy-4-(methylsulphanyl)butylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxy-4-(C-hydroxycarbonimidoyl)butylidene]amino}-1,3-dihydroxypropylidene)amino]-1-hydroxypropylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1,3-dihydroxybutylidene}amino)-4-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[({[1-({1-[(1-{[1-({1-[(1-{2-[(1-{[1-({1-[(1-{[1-({4-carbamimidamido-1-[(1-{[1-(2-{2-[(4-carbamimidamido-1-{[1-({4-carbamimidamido-1-[(1-{[4-carbamimidamido-1-({1-[(1-carboxy-3-methylbutyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-hydroxyethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-3-carboxypropyl]-C-hydroxycarbonimidoyl}butyl)-C-hydroxycarbonimidoyl]pyrrolidine-1-carbonyl}pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-2-phenylethyl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)-2-(C-hydroxycarbonimidoyl)ethyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]pyrrolidin-1-yl}-1-oxopropan-2-yl)-C-hydroxycarbonimidoyl]-2-phenylethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]-2-(4-hydroxyphenyl)ethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-(C-hydroxycarbonimidoyl)ethyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)-2-hydroxypropyl]-C-hydroxycarbonimidoyl}butanoateGenerator
4-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-amino-1-hydroxy-4-(methylsulphanyl)butylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxypropylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxy-3-methylpentylidene}amino)-1-hydroxy-4-(C-hydroxycarbonimidoyl)butylidene]amino}-1,3-dihydroxypropylidene)amino]-1-hydroxypropylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1,3-dihydroxybutylidene}amino)-4-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[({[1-({1-[(1-{[1-({1-[(1-{2-[(1-{[1-({1-[(1-{[1-({4-carbamimidamido-1-[(1-{[1-(2-{2-[(4-carbamimidamido-1-{[1-({4-carbamimidamido-1-[(1-{[4-carbamimidamido-1-({1-[(1-carboxy-3-methylbutyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-hydroxyethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-3-carboxypropyl]-C-hydroxycarbonimidoyl}butyl)-C-hydroxycarbonimidoyl]pyrrolidine-1-carbonyl}pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]butyl}-C-hydroxycarbonimidoyl)-2-phenylethyl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)-2-(C-hydroxycarbonimidoyl)ethyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]pyrrolidin-1-yl}-1-oxopropan-2-yl)-C-hydroxycarbonimidoyl]-2-phenylethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]-2-(4-hydroxyphenyl)ethyl}-C-hydroxycarbonimidoyl)-2-methylpropyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-3-carboxypropyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}-2-(C-hydroxycarbonimidoyl)ethyl)-C-hydroxycarbonimidoyl]-3-methylbutyl}-C-hydroxycarbonimidoyl)-2-hydroxypropyl]-C-hydroxycarbonimidoyl}butanoic acidGenerator
TGF-bGenerator
TGF-ΒGenerator
Chemical FormulaC211H345N61O62S
Average Molecular Weight4760.51
Monoisotopic Molecular Weight4757.543927967
IUPAC Name4-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-amino-4-(methylsulfanyl)butanamido]-4-methylpentanamido}-3-methylbutanamido)propanamido]propanamido}-3-methylpentanamido)-4-carbamoylbutanamido]-3-hydroxypropanamido}propanamido)acetamido]-4-methylpentanamido}-3-hydroxybutanamido)-4-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[({[1-({1-[(1-{[1-({1-[(1-{2-[(1-{[1-({1-[(1-{[1-({4-carbamimidamido-1-[(1-{[1-(2-{2-[(4-carbamimidamido-1-{[1-({4-carbamimidamido-1-[(1-{[4-carbamimidamido-1-({1-[(1-carboxy-3-methylbutyl)carbamoyl]-3-methylbutyl}carbamoyl)butyl]carbamoyl}-2-hydroxyethyl)carbamoyl]butyl}carbamoyl)-3-carboxypropyl]carbamoyl}butyl)carbamoyl]pyrrolidine-1-carbonyl}pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl]carbamoyl}ethyl)carbamoyl]butyl}carbamoyl)-2-phenylethyl]carbamoyl}ethyl)carbamoyl]-3-carboxypropyl}carbamoyl)-2-carbamoylethyl]carbamoyl}-2-hydroxypropyl)carbamoyl]pyrrolidin-1-yl}-1-oxopropan-2-yl)carbamoyl]-2-phenylethyl}carbamoyl)-2-methylpropyl]carbamoyl}-2-hydroxypropyl)carbamoyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl)-2-methylpropyl]carbamoyl}methyl)carbamoyl]-3-carboxypropyl}carbamoyl)butyl]carbamoyl}-2-carbamoylethyl)carbamoyl]-3-methylbutyl}carbamoyl)-2-hydroxypropyl]carbamoyl}butanoic acid
Traditional Name4-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-amino-4-(methylsulfanyl)butanamido]-4-methylpentanamido}-3-methylbutanamido)propanamido]propanamido}-3-methylpentanamido)-4-carbamoylbutanamido]-3-hydroxypropanamido}propanamido)acetamido]-4-methylpentanamido}-3-hydroxybutanamido)-4-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[({[1-({1-[(1-{[1-({1-[(1-{2-[(1-{[1-({1-[(1-{[1-({4-carbamimidamido-1-[(1-{[1-(2-{2-[(4-carbamimidamido-1-{[1-({4-carbamimidamido-1-[(1-{[4-carbamimidamido-1-({1-[(1-carboxy-3-methylbutyl)carbamoyl]-3-methylbutyl}carbamoyl)butyl]carbamoyl}-2-hydroxyethyl)carbamoyl]butyl}carbamoyl)-3-carboxypropyl]carbamoyl}butyl)carbamoyl]pyrrolidine-1-carbonyl}pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl]carbamoyl}ethyl)carbamoyl]butyl}carbamoyl)-2-phenylethyl]carbamoyl}ethyl)carbamoyl]-3-carboxypropyl}carbamoyl)-2-carbamoylethyl]carbamoyl}-2-hydroxypropyl)carbamoyl]pyrrolidin-1-yl}-1-oxopropan-2-yl)carbamoyl]-2-phenylethyl}carbamoyl)-2-methylpropyl]carbamoyl}-2-hydroxypropyl)carbamoyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl)-2-methylpropyl]carbamoyl}methyl)carbamoyl]-3-carboxypropyl}carbamoyl)butyl]carbamoyl}-2-carbamoylethyl)carbamoyl]-3-methylbutyl}carbamoyl)-2-hydroxypropyl]carbamoyl}butanoic acid
CAS Registry NumberNot Available
SMILES
CCC(C)C(NC(=O)C(C)NC(=O)C(C)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CO)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CC1=CC=C(O)C=C1)C(=O)NC(C(C)O)C(=O)NC(C(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O
InChI Identifier
InChI=1S/C211H345N61O62S/c1-32-107(20)161(265-170(297)112(25)233-167(294)109(22)237-195(322)159(105(16)17)263-189(316)136(86-101(8)9)251-171(298)122(212)73-82-335-31)198(325)248-129(63-68-149(213)280)180(307)260-144(96-273)191(318)234-108(21)166(293)231-94-152(283)239-133(83-98(2)3)188(315)267-162(114(27)275)199(326)249-132(67-72-157(291)292)181(308)266-163(115(28)276)200(327)254-135(85-100(6)7)183(310)253-140(92-150(214)281)186(313)242-124(52-40-75-227-208(218)219)175(302)244-128(64-69-154(285)286)172(299)232-95-153(284)262-158(104(14)15)196(323)256-139(91-120-59-61-121(279)62-60-120)190(317)268-165(117(30)278)202(329)264-160(106(18)19)197(324)255-137(89-118-47-35-33-36-48-118)182(309)238-113(26)203(330)270-79-44-57-147(270)194(321)269-164(116(29)277)201(328)257-141(93-151(215)282)187(314)246-130(65-70-155(287)288)174(301)236-110(23)168(295)250-138(90-119-49-37-34-38-50-119)185(312)241-123(51-39-74-226-207(216)217)173(300)235-111(24)169(296)258-142(87-102(10)11)204(331)272-81-46-58-148(272)205(332)271-80-45-56-146(271)193(320)247-127(55-43-78-230-211(224)225)176(303)245-131(66-71-156(289)290)179(306)240-126(54-42-77-229-210(222)223)178(305)261-145(97-274)192(319)243-125(53-41-76-228-209(220)221)177(304)252-134(84-99(4)5)184(311)259-143(206(333)334)88-103(12)13/h33-38,47-50,59-62,98-117,122-148,158-165,273-279H,32,39-46,51-58,63-97,212H2,1-31H3,(H2,213,280)(H2,214,281)(H2,215,282)(H,231,293)(H,232,299)(H,233,294)(H,234,318)(H,235,300)(H,236,301)(H,237,322)(H,238,309)(H,239,283)(H,240,306)(H,241,312)(H,242,313)(H,243,319)(H,244,302)(H,245,303)(H,246,314)(H,247,320)(H,248,325)(H,249,326)(H,250,295)(H,251,298)(H,252,304)(H,253,310)(H,254,327)(H,255,324)(H,256,323)(H,257,328)(H,258,296)(H,259,311)(H,260,307)(H,261,305)(H,262,284)(H,263,316)(H,264,329)(H,265,297)(H,266,308)(H,267,315)(H,268,317)(H,269,321)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,333,334)(H4,216,217,226)(H4,218,219,227)(H4,220,221,228)(H4,222,223,229)(H4,224,225,230)
InChI KeyZRKFYGHZFMAOKI-UHFFFAOYSA-N
Chemical Taxonomy
ClassificationNot classified
Ontology
Not Available
Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP10(-27) g/LChemAxon
pKa (Strongest Acidic)3.06ChemAxon
pKa (Strongest Basic)12.59ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count78ChemAxon
Hydrogen Donor Count70ChemAxon
Polar Surface Area1988.73 ŲChemAxon
Rotatable Bond Count153ChemAxon
Refractivity1242.18 m³·mol⁻¹ChemAxon
Polarizability493.31 ųChemAxon
Number of Rings6ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted Chromatographic Properties

Predicted Kovats Retention Indices

Not Available
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound155011957
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Barupal DK, Fiehn O: Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. Environ Health Perspect. 2019 Sep;127(9):97008. doi: 10.1289/EHP4713. Epub 2019 Sep 26. [PubMed:31557052 ]

Only showing the first 10 proteins. There are 144 proteins in total.

Enzymes

General function:
Involved in transcription cofactor activity
Specific function:
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity.
Gene Name:
EP300
Uniprot ID:
Q09472
Molecular weight:
264159.725
General function:
Involved in transcription cofactor activity
Specific function:
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
Gene Name:
CREBBP
Uniprot ID:
Q92793
Molecular weight:
260991.825
General function:
Involved in receptor signaling protein serine/threonine kinase activity
Specific function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well
Gene Name:
ACVRL1
Uniprot ID:
P37023
Molecular weight:
56124.0
General function:
Involved in receptor signaling protein serine/threonine kinase activity
Specific function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta
Gene Name:
TGFBR2
Uniprot ID:
P37173
Molecular weight:
64567.1
General function:
Involved in transmembrane receptor protein serine/threonine kinase activity
Specific function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta
Gene Name:
TGFBR1
Uniprot ID:
P36897
Molecular weight:
55959.2
General function:
Involved in protein kinase activity
Specific function:
Protein kinase that act on both serine and threonine residues
Gene Name:
STK16
Uniprot ID:
O75716
Molecular weight:
34655.6
General function:
Involved in protein kinase activity
Specific function:
Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development. Isoform 3 is catalytically inactive
Gene Name:
PDPK1
Uniprot ID:
O15530
Molecular weight:
63151.3
General function:
Involved in alpha-1,6-mannosyl-glycoprotein 6-beta-N-ac
Specific function:
Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
Gene Name:
MGAT5
Uniprot ID:
Q09328
Molecular weight:
84542.02
General function:
Involved in acid-amino acid ligase activity
Specific function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK
Gene Name:
NEDD4L
Uniprot ID:
Q96PU5
Molecular weight:
111930.9
General function:
Involved in growth factor activity
Specific function:
Induces cartilage and bone formation
Gene Name:
BMP2
Uniprot ID:
P12643
Molecular weight:
44701.5

Only showing the first 10 proteins. There are 144 proteins in total.