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Showing metabocard for 3-Methoxy-4-hydroxyphenylglycolaldehyde (HMDB0004061)

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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2006-08-13 10:08:18 UTC
Update Date2023-02-21 17:16:52 UTC
HMDB IDHMDB0004061
Secondary Accession Numbers
  • HMDB0006776
  • HMDB04061
  • HMDB06776
Metabolite Identification
Common Name3-Methoxy-4-hydroxyphenylglycolaldehyde
Description
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

  Mrv0541 02231219522D          

 13 13  0  0  0  0            999 V2000
   27.5218  -11.7090    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   28.2364   -8.8214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508  -12.5340    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   30.3797   -9.2339    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508   -9.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   26.8073  -11.2964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.6653   -8.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.2364  -11.2964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508  -11.7090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508  -10.0589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.2364  -10.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.6653  -11.2964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.6653  -10.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  6  1  0  0  0  0
  1  8  1  0  0  0  0
  2  5  1  0  0  0  0
  3  9  1  0  0  0  0
  4  7  2  0  0  0  0
  5  7  1  0  0  0  0
  5 10  1  0  0  0  0
  8  9  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  2  0  0  0  0
 10 13  1  0  0  0  0
 12 13  2  0  0  0  0
M  END
Download

3D MOL for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

HMDB0004061
     RDKit          3D
3-Methoxy-4-hydroxyphenylglycolaldehyde
 23 23  0  0  0  0  0  0  0  0999 V2000
   -2.5889    0.8434    1.5966 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5816   -0.0579    0.5079 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4014   -0.3019   -0.1578 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2374    0.3263    0.2329 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9458    0.0815   -0.4346 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2294    0.7002   -0.0890 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    2.0651    0.1606 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8386   -0.0386    1.0206 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9919   -1.2380    0.9288 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9045   -0.8041   -1.4892 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2401   -1.4378   -1.8927 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211   -1.1934   -1.2263 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6027   -1.8336   -1.6259 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8710    0.5548    2.3794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3140    1.8460    1.1591 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5974    0.9373    2.0353 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2155    1.0288    1.0729 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038    0.5954   -0.9690 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8593    2.2992    0.7686 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    0.4368    1.9314 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8267   -1.0166   -2.0356 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2486   -2.1422   -2.7390 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4631   -1.6508   -1.1348 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  5 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12  3  1  0
  1 14  1  0
  1 15  1  0
  1 16  1  0
  4 17  1  0
  6 18  1  0
  7 19  1  0
  8 20  1  0
 10 21  1  0
 11 22  1  0
 13 23  1  0
M  END
Download

3D SDF for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

  Mrv0541 02231219522D          

 13 13  0  0  0  0            999 V2000
   27.5218  -11.7090    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   28.2364   -8.8214    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508  -12.5340    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   30.3797   -9.2339    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508   -9.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   26.8073  -11.2964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.6653   -8.8214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.2364  -11.2964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508  -11.7090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.9508  -10.0589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   28.2364  -10.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.6653  -11.2964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   29.6653  -10.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  6  1  0  0  0  0
  1  8  1  0  0  0  0
  2  5  1  0  0  0  0
  3  9  1  0  0  0  0
  4  7  2  0  0  0  0
  5  7  1  0  0  0  0
  5 10  1  0  0  0  0
  8  9  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  2  0  0  0  0
 10 13  1  0  0  0  0
 12 13  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0004061

> <DATABASE_NAME>
hmdb

> <SMILES>
COC1=C(O)C=CC(=C1)C(O)C=O

> <INCHI_IDENTIFIER>
InChI=1S/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3

> <INCHI_KEY>
VISAJVAPYPFKCL-UHFFFAOYSA-N

> <FORMULA>
C9H10O4

> <MOLECULAR_WEIGHT>
182.1733

> <EXACT_MASS>
182.057908808

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_AVERAGE_POLARIZABILITY>
17.671285440421318

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetaldehyde

> <ALOGPS_LOGP>
0.49

> <JCHEM_LOGP>
0.27598280499999994

> <ALOGPS_LOGS>
-1.55

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.947572767111232

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.903212004669111

> <JCHEM_PKA_STRONGEST_BASIC>
-3.756563475609691

> <JCHEM_POLAR_SURFACE_AREA>
66.75999999999999

> <JCHEM_REFRACTIVITY>
46.22250000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.13e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetaldehyde

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

HMDB0004061
     RDKit          3D
3-Methoxy-4-hydroxyphenylglycolaldehyde
 23 23  0  0  0  0  0  0  0  0999 V2000
   -2.5889    0.8434    1.5966 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5816   -0.0579    0.5079 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4014   -0.3019   -0.1578 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2374    0.3263    0.2329 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9458    0.0815   -0.4346 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2294    0.7002   -0.0890 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    2.0651    0.1606 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8386   -0.0386    1.0206 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9919   -1.2380    0.9288 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9045   -0.8041   -1.4892 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2401   -1.4378   -1.8927 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211   -1.1934   -1.2263 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6027   -1.8336   -1.6259 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8710    0.5548    2.3794 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3140    1.8460    1.1591 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5974    0.9373    2.0353 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2155    1.0288    1.0729 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9038    0.5954   -0.9690 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8593    2.2992    0.7686 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    0.4368    1.9314 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8267   -1.0166   -2.0356 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2486   -2.1422   -2.7390 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4631   -1.6508   -1.1348 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  8  9  2  0
  5 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12  3  1  0
  1 14  1  0
  1 15  1  0
  1 16  1  0
  4 17  1  0
  6 18  1  0
  7 19  1  0
  8 20  1  0
 10 21  1  0
 11 22  1  0
 13 23  1  0
M  END
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PDB for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  O   UNK     0      51.374 -21.857   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      52.708 -16.467   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      54.041 -23.397   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      56.709 -17.237   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      54.041 -17.237   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      50.040 -21.087   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      55.375 -16.467   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      52.708 -21.087   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      54.041 -21.857   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      54.041 -18.777   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      52.708 -19.547   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      55.375 -21.087   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      55.375 -19.547   0.000  0.00  0.00           C+0
CONECT    1    6    8                                                       
CONECT    2    5                                                            
CONECT    3    9                                                            
CONECT    4    7                                                            
CONECT    5    2    7   10                                                  
CONECT    6    1                                                            
CONECT    7    4    5                                                       
CONECT    8    1    9   11                                                  
CONECT    9    3    8   12                                                  
CONECT   10    5   11   13                                                  
CONECT   11    8   10                                                       
CONECT   12    9   13                                                       
CONECT   13   10   12                                                       
MASTER        0    0    0    0    0    0    0    0   13    0   26    0
END
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3D PDB for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

COMPND    HMDB0004061
HETATM    1  C1  UNL     1      -2.589   0.843   1.597  1.00  0.00           C  
HETATM    2  O1  UNL     1      -2.582  -0.058   0.508  1.00  0.00           O  
HETATM    3  C2  UNL     1      -1.401  -0.302  -0.158  1.00  0.00           C  
HETATM    4  C3  UNL     1      -0.237   0.326   0.233  1.00  0.00           C  
HETATM    5  C4  UNL     1       0.946   0.082  -0.435  1.00  0.00           C  
HETATM    6  C5  UNL     1       2.229   0.700  -0.089  1.00  0.00           C  
HETATM    7  O2  UNL     1       2.119   2.065   0.161  1.00  0.00           O  
HETATM    8  C6  UNL     1       2.839  -0.039   1.021  1.00  0.00           C  
HETATM    9  O3  UNL     1       2.992  -1.238   0.929  1.00  0.00           O  
HETATM   10  C7  UNL     1       0.905  -0.804  -1.489  1.00  0.00           C  
HETATM   11  C8  UNL     1      -0.240  -1.438  -1.893  1.00  0.00           C  
HETATM   12  C9  UNL     1      -1.421  -1.193  -1.226  1.00  0.00           C  
HETATM   13  O4  UNL     1      -2.603  -1.834  -1.626  1.00  0.00           O  
HETATM   14  H1  UNL     1      -1.871   0.555   2.379  1.00  0.00           H  
HETATM   15  H2  UNL     1      -2.314   1.846   1.159  1.00  0.00           H  
HETATM   16  H3  UNL     1      -3.597   0.937   2.035  1.00  0.00           H  
HETATM   17  H4  UNL     1      -0.215   1.029   1.073  1.00  0.00           H  
HETATM   18  H5  UNL     1       2.904   0.595  -0.969  1.00  0.00           H  
HETATM   19  H6  UNL     1       2.859   2.299   0.769  1.00  0.00           H  
HETATM   20  H7  UNL     1       3.164   0.437   1.931  1.00  0.00           H  
HETATM   21  H8  UNL     1       1.827  -1.017  -2.036  1.00  0.00           H  
HETATM   22  H9  UNL     1      -0.249  -2.142  -2.739  1.00  0.00           H  
HETATM   23  H10 UNL     1      -3.463  -1.651  -1.135  1.00  0.00           H  
CONECT    1    2   14   15   16
CONECT    2    3
CONECT    3    4    4   12
CONECT    4    5   17
CONECT    5    6   10   10
CONECT    6    7    8   18
CONECT    7   19
CONECT    8    9    9   20
CONECT   10   11   21
CONECT   11   12   12   22
CONECT   12   13
CONECT   13   23
END
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SMILES for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

COC1=C(O)C=CC(=C1)C(O)C=O
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INCHI for HMDB0004061 (3-Methoxy-4-hydroxyphenylglycolaldehyde)

InChI=1S/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
4-Hydroxy-3-methoxy mandelaldehydeHMDB
4-Hydroxy-3-methoxymandelaldehydeHMDB
4-Hydroxy-3-methoxyphenylglycolaldehydeHMDB
a,4-Dihydroxy-3-methoxy-benzeneacetaldehydeHMDB
Chemical FormulaC9H10O4
Average Molecular Weight182.1733
Monoisotopic Molecular Weight182.057908808
IUPAC Name2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetaldehyde
Traditional Name2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetaldehyde
CAS Registry Number17592-23-3
SMILES
COC1=C(O)C=CC(=C1)C(O)C=O
InChI Identifier
InChI=1S/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3
InChI KeyVISAJVAPYPFKCL-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassPhenols
Sub ClassMethoxyphenols
Direct ParentMethoxyphenols
Alternative Parents
Substituents
  • Methoxyphenol
  • Phenylacetaldehyde
  • Anisole
  • Phenoxy compound
  • Phenol ether
  • Methoxybenzene
  • 1-hydroxy-2-unsubstituted benzenoid
  • Alkyl aryl ether
  • Monocyclic benzene moiety
  • Alpha-hydroxyaldehyde
  • Secondary alcohol
  • Ether
  • Aromatic alcohol
  • Organooxygen compound
  • Aldehyde
  • Carbonyl group
  • Alcohol
  • Hydrocarbon derivative
  • Organic oxide
  • Organic oxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Route of exposureSource
Process
Naturally occurring process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP0.517Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023294
KNApSAcK IDNot Available
Chemspider ID389601
KEGG Compound IDC05583
BioCyc IDNot Available
BiGG ID46069
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound440729
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH ID3M4HPGA
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Kawamura M, Eisenhofer G, Kopin IJ, Kador PF, Lee YS, Fujisawa S, Sato S: Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia. Auton Neurosci. 2002 Mar 18;96(2):131-9. [PubMed:11958479 ]
  2. Evangelou AM, Malamas MP, Vezyraki P, Karkabounas SC: Is epinephrine-induced platelet aggregation autoregulated by its metabolic degradation products in vivo? In Vivo. 1998 May-Jun;12(3):321-5. [PubMed:9706478 ]

Enzymes

Enzyme Details
1. Amine oxidase [flavin-containing] B
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Gene Name:
MAOB
Uniprot ID:
P27338
Molecular weight:
58762.475
Reactions
Normetanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxidedetails
Metanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylaminedetails
Enzyme Details
2. Amine oxidase [flavin-containing] A
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular weight:
59681.27
Reactions
Normetanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Ammonia + Hydrogen peroxidedetails
Metanephrine + Water + Oxygen → 3-Methoxy-4-hydroxyphenylglycolaldehyde + Hydrogen peroxide + Methylaminedetails
Enzyme Details
3. Aldehyde dehydrogenase, dimeric NADP-preferring
General function:
Involved in oxidoreductase activity
Specific function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
Gene Name:
ALDH3A1
Uniprot ID:
P30838
Molecular weight:
50394.57
Reactions
3-Methoxy-4-hydroxyphenylglycolaldehyde + NAD + Water → Vanillylmandelic acid + NADH + Hydrogen Iondetails
3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water → Vanillylmandelic acid + NADPH + Hydrogen Iondetails
Enzyme Details
4. Aldehyde dehydrogenase family 1 member A3
General function:
Involved in oxidoreductase activity
Specific function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
Gene Name:
ALDH1A3
Uniprot ID:
P47895
Molecular weight:
56107.995
Reactions
3-Methoxy-4-hydroxyphenylglycolaldehyde + NAD + Water → Vanillylmandelic acid + NADH + Hydrogen Iondetails
3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water → Vanillylmandelic acid + NADPH + Hydrogen Iondetails
Enzyme Details
5. Aldehyde dehydrogenase family 3 member B2
General function:
Involved in oxidoreductase activity
Specific function:
Not Available
Gene Name:
ALDH3B2
Uniprot ID:
P48448
Molecular weight:
42623.62
Reactions
3-Methoxy-4-hydroxyphenylglycolaldehyde + NAD + Water → Vanillylmandelic acid + NADH + Hydrogen Iondetails
3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water → Vanillylmandelic acid + NADPH + Hydrogen Iondetails
Enzyme Details
6. Aldehyde dehydrogenase family 3 member B1
General function:
Involved in oxidoreductase activity
Specific function:
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.
Gene Name:
ALDH3B1
Uniprot ID:
P43353
Molecular weight:
51839.245
Reactions
3-Methoxy-4-hydroxyphenylglycolaldehyde + NAD + Water → Vanillylmandelic acid + NADH + Hydrogen Iondetails
3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP + Water → Vanillylmandelic acid + NADPH + Hydrogen Iondetails