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Record Information

Version

5.0

Status

Detected but not Quantified

Creation Date

2007-05-22 19:18:26 UTC

Update Date

2021-09-14 15:41:42 UTC

HMDB ID

HMDB0006248

Secondary Accession Numbers

HMDB0029142
HMDB0061369
HMDB06248
HMDB29142
HMDB61369

Metabolite Identification

Common Name

gamma-Glutamylalanine

Description

gamma-Glutamylalanine is a dipeptide composed of gamma-glutamate and alanine, and is a proteolytic breakdown product of larger proteins. It belongs to the family of N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. gamma-Glutamylalanine is a natural substrate of the enzyme (5-L-glutamyl)-L-amino acid 5-glutamyltransferase (cyclizing) (g-glutamylcyclotransferase, EC 2.3.2.2) in the glutathione metabolism pathway, which cleaves gamma-glutamylalanine to produce L-5-oxoproline. gamma-Glutamylcyclotransferase is widely distributed in both human and animal tissues where it catalyzes the scission of the y-peptide bonds of many different gamma-glutamyl-amino acids and gamma-glutamyl-gamma-glutamyl-amino acids. The latter are 'better' substrates of the enzyme than the corresponding gamma-glutamyl-amino acids (PMID: 2570694 , 2893631 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0006248
     RDKit          3D
gamma-Glutamylalanine
 29 28  0  0  0  0  0  0  0  0999 V2000
   -3.7285    0.7705   -0.9520 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9502    0.0783    0.1670 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.6130   -0.2211   -0.2452 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4945    0.3678    0.3806 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6491    1.1806    1.3280 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8714    0.0384   -0.0675 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.7616    0.7171 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2864    0.3660    0.1925 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4831    0.6781   -1.1791 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5255   -1.0839    0.4025 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4048   -1.5818    1.5608 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8836   -1.9426   -0.6324 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6953   -1.1376    0.5207 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1059   -2.2540    0.4271 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0142   -1.0907    0.9497 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3711    1.8164   -1.0085 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5924    0.2200   -1.9003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8014    0.7187   -0.6886 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9136    0.8083    1.0092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4865   -0.8971   -1.0329 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0595   -1.0494   -0.0360 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9898    0.3448   -1.1458 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7457    1.8490    0.6081 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8473    0.4540    1.7778 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0640    0.9206    0.7907 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019    0.0329   -1.6956 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6303    1.6815   -1.3920 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8793   -2.1755   -0.6978 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2799   -0.6866    1.8417 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
  2 13  1  0
 13 14  2  0
 13 15  1  0
  1 16  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  1
  3 20  1  0
  6 21  1  0
  6 22  1  0
  7 23  1  0
  7 24  1  0
  8 25  1  1
  9 26  1  0
  9 27  1  0
 12 28  1  0
 15 29  1  0
M  END

      
  Mrv1652312091700132D          

 15 14  0  0  0  0            999 V2000
 2498.9276 2500.2058    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 2499.6425 2499.7940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2500.3574 2500.2058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2501.0723 2499.7940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2501.7875 2500.2058    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 2502.5023 2499.7940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2503.2172 2500.2058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2502.5023 2498.9684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2501.7875 2501.0315    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 2499.6425 2498.9684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2498.2123 2499.7940    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 2497.4975 2500.2058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2496.7826 2499.7940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2497.4975 2501.0315    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2498.2123 2498.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1 11  1  0  0  0  0
  2  3  1  0  0  0  0
  2 10  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  9  1  6  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
 11 12  1  0  0  0  0
 11 15  1  1  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0006248

> <DATABASE_NAME>
hmdb

> <SMILES>
C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1

> <INCHI_KEY>
WQXXXVRAFAKQJM-WHFBIAKZSA-N

> <FORMULA>
C8H14N2O5

> <MOLECULAR_WEIGHT>
218.2072

> <EXACT_MASS>
218.090271568

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
29

> <JCHEM_AVERAGE_POLARIZABILITY>
20.935963393730972

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-amino-4-{[(1S)-1-carboxyethyl]carbamoyl}butanoic acid

> <ALOGPS_LOGP>
-3.36

> <JCHEM_LOGP>
-3.8159177947397183

> <ALOGPS_LOGS>
-1.23

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
3.825455393275773

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.9295800715632931

> <JCHEM_PKA_STRONGEST_BASIC>
9.312086881878784

> <JCHEM_POLAR_SURFACE_AREA>
129.71999999999997

> <JCHEM_REFRACTIVITY>
48.58510000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.29e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
g-glu-ala

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0006248
     RDKit          3D
gamma-Glutamylalanine
 29 28  0  0  0  0  0  0  0  0999 V2000
   -3.7285    0.7705   -0.9520 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9502    0.0783    0.1670 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.6130   -0.2211   -0.2452 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4945    0.3678    0.3806 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6491    1.1806    1.3280 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8714    0.0384   -0.0675 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.7616    0.7171 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2864    0.3660    0.1925 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4831    0.6781   -1.1791 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5255   -1.0839    0.4025 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4048   -1.5818    1.5608 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8836   -1.9426   -0.6324 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6953   -1.1376    0.5207 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1059   -2.2540    0.4271 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0142   -1.0907    0.9497 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3711    1.8164   -1.0085 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5924    0.2200   -1.9003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8014    0.7187   -0.6886 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9136    0.8083    1.0092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4865   -0.8971   -1.0329 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0595   -1.0494   -0.0360 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9898    0.3448   -1.1458 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7457    1.8490    0.6081 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8473    0.4540    1.7778 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0640    0.9206    0.7907 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019    0.0329   -1.6956 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6303    1.6815   -1.3920 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8793   -2.1755   -0.6978 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2799   -0.6866    1.8417 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
  2 13  1  0
 13 14  2  0
 13 15  1  0
  1 16  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  1
  3 20  1  0
  6 21  1  0
  6 22  1  0
  7 23  1  0
  7 24  1  0
  8 25  1  1
  9 26  1  0
  9 27  1  0
 12 28  1  0
 15 29  1  0
M  END

HEADER    PROTEIN                                 09-DEC-17   NONE
TITLE     NULL                                                        
COMPND    MOLECULE:                                                   
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   09-DEC-17         0                                  
HETATM    1  N   UNK     0    4664.6654667.051   0.000  0.00  0.00           N+0
HETATM    2  C   UNK     0    4665.9994666.282   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0    4667.3344667.051   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0    4668.6684666.282   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0    4670.0034667.051   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0    4671.3384666.282   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0    4672.6724667.051   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0    4671.3384664.741   0.000  0.00  0.00           O+0
HETATM    9  N   UNK     0    4670.0034668.592   0.000  0.00  0.00           N+0
HETATM   10  O   UNK     0    4665.9994664.741   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0    4663.3304666.282   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0    4661.9954667.051   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0    4660.6614666.282   0.000  0.00  0.00           O+0
HETATM   14  O   UNK     0    4661.9954668.592   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0    4663.3304664.741   0.000  0.00  0.00           C+0
CONECT    1    2   11                                                       
CONECT    2    1    3   10                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    9                                                  
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6                                                            
CONECT    9    5                                                            
CONECT   10    2                                                            
CONECT   11    1   12   15                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12                                                            
CONECT   15   11                                                            
MASTER        0    0    0    0    0    0    0    0   15    0   28    0
END

COMPND    HMDB0006248
HETATM    1  C1  UNL     1      -3.729   0.770  -0.952  1.00  0.00           C  
HETATM    2  C2  UNL     1      -2.950   0.078   0.167  1.00  0.00           C  
HETATM    3  N1  UNL     1      -1.613  -0.221  -0.245  1.00  0.00           N  
HETATM    4  C3  UNL     1      -0.495   0.368   0.381  1.00  0.00           C  
HETATM    5  O1  UNL     1      -0.649   1.181   1.328  1.00  0.00           O  
HETATM    6  C4  UNL     1       0.871   0.038  -0.068  1.00  0.00           C  
HETATM    7  C5  UNL     1       1.923   0.762   0.717  1.00  0.00           C  
HETATM    8  C6  UNL     1       3.286   0.366   0.193  1.00  0.00           C  
HETATM    9  N2  UNL     1       3.483   0.678  -1.179  1.00  0.00           N  
HETATM   10  C7  UNL     1       3.525  -1.084   0.403  1.00  0.00           C  
HETATM   11  O2  UNL     1       3.405  -1.582   1.561  1.00  0.00           O  
HETATM   12  O3  UNL     1       3.884  -1.943  -0.632  1.00  0.00           O  
HETATM   13  C8  UNL     1      -3.695  -1.138   0.521  1.00  0.00           C  
HETATM   14  O4  UNL     1      -3.106  -2.254   0.427  1.00  0.00           O  
HETATM   15  O5  UNL     1      -5.014  -1.091   0.950  1.00  0.00           O  
HETATM   16  H1  UNL     1      -3.371   1.816  -1.008  1.00  0.00           H  
HETATM   17  H2  UNL     1      -3.592   0.220  -1.900  1.00  0.00           H  
HETATM   18  H3  UNL     1      -4.801   0.719  -0.689  1.00  0.00           H  
HETATM   19  H4  UNL     1      -2.914   0.808   1.009  1.00  0.00           H  
HETATM   20  H5  UNL     1      -1.486  -0.897  -1.033  1.00  0.00           H  
HETATM   21  H6  UNL     1       1.060  -1.049  -0.036  1.00  0.00           H  
HETATM   22  H7  UNL     1       0.990   0.345  -1.146  1.00  0.00           H  
HETATM   23  H8  UNL     1       1.746   1.849   0.608  1.00  0.00           H  
HETATM   24  H9  UNL     1       1.847   0.454   1.778  1.00  0.00           H  
HETATM   25  H10 UNL     1       4.064   0.921   0.791  1.00  0.00           H  
HETATM   26  H11 UNL     1       4.102   0.033  -1.696  1.00  0.00           H  
HETATM   27  H12 UNL     1       3.630   1.682  -1.392  1.00  0.00           H  
HETATM   28  H13 UNL     1       4.879  -2.175  -0.698  1.00  0.00           H  
HETATM   29  H14 UNL     1      -5.280  -0.687   1.842  1.00  0.00           H  
CONECT    1    2   16   17   18
CONECT    2    3   13   19
CONECT    3    4   20
CONECT    4    5    5    6
CONECT    6    7   21   22
CONECT    7    8   23   24
CONECT    8    9   10   25
CONECT    9   26   27
CONECT   10   11   11   12
CONECT   12   28
CONECT   13   14   14   15
CONECT   15   29
END

HMDB0006248
     RDKit          3D
gamma-Glutamylalanine
 29 28  0  0  0  0  0  0  0  0999 V2000
   -3.7285    0.7705   -0.9520 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9502    0.0783    0.1670 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.6130   -0.2211   -0.2452 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4945    0.3678    0.3806 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6491    1.1806    1.3280 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8714    0.0384   -0.0675 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.7616    0.7171 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2864    0.3660    0.1925 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4831    0.6781   -1.1791 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5255   -1.0839    0.4025 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4048   -1.5818    1.5608 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8836   -1.9426   -0.6324 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6953   -1.1376    0.5207 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1059   -2.2540    0.4271 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0142   -1.0907    0.9497 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3711    1.8164   -1.0085 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5924    0.2200   -1.9003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8014    0.7187   -0.6886 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9136    0.8083    1.0092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4865   -0.8971   -1.0329 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0595   -1.0494   -0.0360 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9898    0.3448   -1.1458 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7457    1.8490    0.6081 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8473    0.4540    1.7778 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0640    0.9206    0.7907 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019    0.0329   -1.6956 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6303    1.6815   -1.3920 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8793   -2.1755   -0.6978 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2799   -0.6866    1.8417 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  8 10  1  0
 10 11  2  0
 10 12  1  0
  2 13  1  0
 13 14  2  0
 13 15  1  0
  1 16  1  0
  1 17  1  0
  1 18  1  0
  2 19  1  1
  3 20  1  0
  6 21  1  0
  6 22  1  0
  7 23  1  0
  7 24  1  0
  8 25  1  1
  9 26  1  0
  9 27  1  0
 12 28  1  0
 15 29  1  0
M  END

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
5-L-Glutamyl-L-alanine	ChEBI
gamma-L-Glutamyl-L-alanine	ChEBI
L-gamma-Glu-L-ala	ChEBI
N-L-gamma-Glutamyl-L-alanine	ChEBI
g-L-Glutamyl-L-alanine	Generator
Γ-L-glutamyl-L-alanine	Generator
L-g-Glu-L-ala	Generator
L-Γ-glu-L-ala	Generator
N-L-g-Glutamyl-L-alanine	Generator
N-L-Γ-glutamyl-L-alanine	Generator
g-Glutamylalanine	Generator
Γ-glutamylalanine	Generator
γ-Glu-Ala	HMDB
γ-L-Glu-L-Ala	HMDB
L-γ-Glutamyl-L-alanine	HMDB
N-γ-Glutamylalanine	HMDB
N-L-γ-Glutamylalanine	HMDB
gamma-Glu-Ala	HMDB
gamma-L-Glu-L-Ala	HMDB
L-gamma-Glutamyl-L-alanine	HMDB
N-gamma-Glutamylalanine	HMDB
N-L-gamma-Glutamylalanine	HMDB
gamma-Glutamylalanine	HMDB, ChEBI
5-L-Glutamylalanine	HMDB
g-Glu-Ala	HMDB
N-γ-L-Glutamyl-L-alanine	HMDB
N-gamma-L-Glutamyl-L-alanine	HMDB

Chemical Formula

C₈H₁₄N₂O₅

Average Molecular Weight

218.2072

Monoisotopic Molecular Weight

218.090271568

IUPAC Name

(2S)-2-amino-4-{[(1S)-1-carboxyethyl]carbamoyl}butanoic acid

Traditional Name

g-glu-ala

CAS Registry Number

5875-41-2

SMILES

C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1

InChI Key

WQXXXVRAFAKQJM-WHFBIAKZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Dipeptides

Alternative Parents

Substituents

Alpha-dipeptide
Gamma-glutamyl alpha-amino acid
Glutamine or derivatives
N-acyl-l-alpha-amino acid
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
Alanine or derivatives
Alpha-amino acid
Alpha-amino acid or derivatives
L-alpha-amino acid
Dicarboxylic acid or derivatives
Fatty amide
N-acyl-amine
Fatty acyl
Fatty acid
Amino acid or derivatives
Carboxamide group
Amino acid
Secondary carboxylic acid amide
Carboxylic acid
Hydrocarbon derivative
Primary aliphatic amine
Organic oxygen compound
Organic oxide
Organopnictogen compound
Organic nitrogen compound
Carbonyl group
Amine
Primary amine
Organonitrogen compound
Organooxygen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

gamma-glutamylalanine (CHEBI:50619 )

Ontology

Physiological effect

Health effect

Circulatory system disorder

Vascular disorder

Atherosclerosis (PMID: 21475195)

Endocrine system disorder

Breast disorder

Breast cancer (PMID: 9468591)

Digestive system disorder

Gastrointestinal disorder

Lower gastrointestinal disorder

Ulcerative colitis (PMID: 33440385)

Cancer

Cervical cancer (PMID: 26566624)

Disposition

Biological location

Cell

All cells and tissues (HMDB: HMDB0285681)

Cellular substructure

Organelle

Endoplasmic reticulum (HMDB: HMDB0285681)

Golgi apparatus membrane (HMDB: HMDB0285681)
Cell membrane (HMDB: HMDB0285681)

Source

Endogenous

Endogenous (HMDB: HMDB0285681)

Process

Naturally occurring process

Biological process

Biochemical pathway

Metabolic pathway

Phosphatidylcholine Biosynthesis (HMDB: HMDB0285681)

Cellular process

Apoptosis (PMID: 23350810)
Cell proliferation (PMID: 23350810)

Biochemical process

Lipid transport (PMID: 21979151)

Role

Biological role

Nutrient (PMID: 28411170)

Industrial application

Pharmaceutical industry

Biomarker

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct Type	Data Source	CCS Value (Å²)	Reference
[M-H]-	Not Available	140.249	http://allccs.zhulab.cn/database/detail?ID=AllCCS00000066
[M+H]+	Not Available	149.722	http://allccs.zhulab.cn/database/detail?ID=AllCCS00000066

Predicted Molecular Properties

Property	Value	Source
Water Solubility	12.9 g/L	ALOGPS
logP	-3.4	ALOGPS
logP	-3.8	ChemAxon
logS	-1.2	ALOGPS
pKa (Strongest Acidic)	1.93	ChemAxon
pKa (Strongest Basic)	9.31	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	129.72 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	48.59 m³·mol⁻¹	ChemAxon
Polarizability	20.94 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	151.147	31661259
DarkChem	[M-H]-	147.394	31661259
DeepCCS	[M+H]+	149.396	30932474
DeepCCS	[M-H]-	147.001	30932474
DeepCCS	[M-2H]-	180.102	30932474
DeepCCS	[M+Na]+	155.37	30932474
AllCCS	[M+H]+	149.1	32859911
AllCCS	[M+H-H2O]+	145.7	32859911
AllCCS	[M+NH4]+	152.3	32859911
AllCCS	[M+Na]+	153.2	32859911
AllCCS	[M-H]-	146.3	32859911
AllCCS	[M+Na-2H]-	147.2	32859911
AllCCS	[M+HCOO]-	148.3	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
gamma-Glutamylalanine	C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O	2993.6	Standard polar	33892256
gamma-Glutamylalanine	C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O	1740.8	Standard non polar	33892256
gamma-Glutamylalanine	C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O	2234.9	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
gamma-Glutamylalanine,1TMS,isomer #1	C[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)O	1962.8	Semi standard non polar	33892256
gamma-Glutamylalanine,1TMS,isomer #2	C[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O[Si](C)(C)C	1992.2	Semi standard non polar	33892256
gamma-Glutamylalanine,1TMS,isomer #3	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)O	2031.0	Semi standard non polar	33892256
gamma-Glutamylalanine,1TMS,isomer #4	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C	2035.9	Semi standard non polar	33892256
gamma-Glutamylalanine,2TMS,isomer #1	C[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	1996.1	Semi standard non polar	33892256
gamma-Glutamylalanine,2TMS,isomer #2	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O	2061.3	Semi standard non polar	33892256
gamma-Glutamylalanine,2TMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2009.5	Semi standard non polar	33892256
gamma-Glutamylalanine,2TMS,isomer #4	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)O[Si](C)(C)C	2075.7	Semi standard non polar	33892256
gamma-Glutamylalanine,2TMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C	2027.0	Semi standard non polar	33892256
gamma-Glutamylalanine,2TMS,isomer #6	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)[Si](C)(C)C	2086.6	Semi standard non polar	33892256
gamma-Glutamylalanine,2TMS,isomer #7	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	2167.2	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #1	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	2107.2	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #1	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	2088.1	Standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #1	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C	2564.1	Standard polar	33892256
gamma-Glutamylalanine,3TMS,isomer #2	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2038.6	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #2	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2091.7	Standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #2	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2953.7	Standard polar	33892256
gamma-Glutamylalanine,3TMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2077.2	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2119.4	Standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2677.5	Standard polar	33892256
gamma-Glutamylalanine,3TMS,isomer #4	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	2205.0	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #4	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	2112.0	Standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #4	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O	2825.9	Standard polar	33892256
gamma-Glutamylalanine,3TMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)[Si](C)(C)C	2091.7	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)[Si](C)(C)C	2098.4	Standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)[Si](C)(C)C	2658.2	Standard polar	33892256
gamma-Glutamylalanine,3TMS,isomer #6	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	2216.8	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #6	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	2153.2	Standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #6	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	2701.4	Standard polar	33892256
gamma-Glutamylalanine,3TMS,isomer #7	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2187.6	Semi standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #7	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2168.7	Standard non polar	33892256
gamma-Glutamylalanine,3TMS,isomer #7	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2821.9	Standard polar	33892256
gamma-Glutamylalanine,4TMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2096.4	Semi standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2153.1	Standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)[Si](C)(C)C	2289.3	Standard polar	33892256
gamma-Glutamylalanine,4TMS,isomer #2	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	2252.5	Semi standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #2	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	2182.5	Standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #2	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)C(=O)O[Si](C)(C)C	2411.4	Standard polar	33892256
gamma-Glutamylalanine,4TMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2226.0	Semi standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2228.0	Standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2546.1	Standard polar	33892256
gamma-Glutamylalanine,4TMS,isomer #4	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2218.0	Semi standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #4	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2244.2	Standard non polar	33892256
gamma-Glutamylalanine,4TMS,isomer #4	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2452.6	Standard polar	33892256
gamma-Glutamylalanine,5TMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2270.2	Semi standard non polar	33892256
gamma-Glutamylalanine,5TMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2256.3	Standard non polar	33892256
gamma-Glutamylalanine,5TMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C)N([Si](C)(C)C)[Si](C)(C)C)[Si](C)(C)C	2233.1	Standard polar	33892256
gamma-Glutamylalanine,1TBDMS,isomer #1	C[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O	2230.4	Semi standard non polar	33892256
gamma-Glutamylalanine,1TBDMS,isomer #2	C[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)O[Si](C)(C)C(C)(C)C	2248.9	Semi standard non polar	33892256
gamma-Glutamylalanine,1TBDMS,isomer #3	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)C(=O)O	2288.8	Semi standard non polar	33892256
gamma-Glutamylalanine,1TBDMS,isomer #4	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C	2270.1	Semi standard non polar	33892256
gamma-Glutamylalanine,2TBDMS,isomer #1	C[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2469.9	Semi standard non polar	33892256
gamma-Glutamylalanine,2TBDMS,isomer #2	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O	2529.5	Semi standard non polar	33892256
gamma-Glutamylalanine,2TBDMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2483.0	Semi standard non polar	33892256
gamma-Glutamylalanine,2TBDMS,isomer #4	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)C(=O)O[Si](C)(C)C(C)(C)C	2537.5	Semi standard non polar	33892256
gamma-Glutamylalanine,2TBDMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C	2479.8	Semi standard non polar	33892256
gamma-Glutamylalanine,2TBDMS,isomer #6	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)[Si](C)(C)C(C)(C)C	2533.1	Semi standard non polar	33892256
gamma-Glutamylalanine,2TBDMS,isomer #7	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O	2616.8	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #1	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2755.8	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #1	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2651.6	Standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #1	C[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2817.5	Standard polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #2	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2686.9	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #2	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2683.1	Standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #2	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3056.2	Standard polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2756.4	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2654.5	Standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2891.7	Standard polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #4	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O	2894.6	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #4	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O	2672.9	Standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #4	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O	2958.6	Standard polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)[Si](C)(C)C(C)(C)C	2770.0	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)[Si](C)(C)C(C)(C)C	2660.3	Standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #5	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)[Si](C)(C)C(C)(C)C	2877.6	Standard polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #6	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2886.8	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #6	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2689.2	Standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #6	C[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2879.3	Standard polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #7	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2871.9	Semi standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #7	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2702.4	Standard non polar	33892256
gamma-Glutamylalanine,3TBDMS,isomer #7	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2964.2	Standard polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2951.3	Semi standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2859.6	Standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2767.3	Standard polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #2	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	3109.2	Semi standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #2	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2893.3	Standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #2	C[C@H](NC(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C	2785.1	Standard polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3112.3	Semi standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2918.2	Standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #3	C[C@@H](C(=O)O)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2871.1	Standard polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #4	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3106.0	Semi standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #4	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2923.0	Standard non polar	33892256
gamma-Glutamylalanine,4TBDMS,isomer #4	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2813.4	Standard polar	33892256
gamma-Glutamylalanine,5TBDMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3315.9	Semi standard non polar	33892256
gamma-Glutamylalanine,5TBDMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	3099.9	Standard non polar	33892256
gamma-Glutamylalanine,5TBDMS,isomer #1	C[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N(C(=O)CC[C@@H](C(=O)O[Si](C)(C)C(C)(C)C)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C	2780.1	Standard polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - gamma-Glutamylalanine GC-MS (Non-derivatized) - 70eV, Positive	splash10-00al-9710000000-e2845b73a5e7cd81881f	2016-09-22	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - gamma-Glutamylalanine GC-MS (2 TMS) - 70eV, Positive	splash10-00dj-9332000000-f7980440d2535885b7ab	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - gamma-Glutamylalanine GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - gamma-Glutamylalanine GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 10V, Positive-QTOF	splash10-00xr-2940000000-948d6e9385d802328937	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 20V, Positive-QTOF	splash10-05br-6900000000-5f1480e854581ee71678	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 40V, Positive-QTOF	splash10-0a4r-9200000000-58a633696455e707016d	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 10V, Negative-QTOF	splash10-014i-0690000000-92c8a111979eb46fa59f	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 20V, Negative-QTOF	splash10-06dj-2930000000-1156c919eda2b8e49fae	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 40V, Negative-QTOF	splash10-0076-9200000000-737e76bca1d968721a2a	2016-09-12	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 10V, Positive-QTOF	splash10-000x-9330000000-8674f1f30751437e8bf9	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 20V, Positive-QTOF	splash10-001i-9300000000-a9c7516230cc6b7166c1	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 40V, Positive-QTOF	splash10-053u-9100000000-bb369086fe31b624af6c	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 10V, Negative-QTOF	splash10-056r-1900000000-491b535e4d4e3214438c	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 20V, Negative-QTOF	splash10-000i-9100000000-51f9fd3eeccf33a98c1c	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - gamma-Glutamylalanine 40V, Negative-QTOF	splash10-000f-9000000000-d6a5f92f606e802c70be	2021-09-22	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular

Biospecimen Locations

Feces

Tissue Locations

Placenta

Pathways

Name	SMPDB/PathBank	KEGG
Glutathione metabolism	Not Available
Glutathione Synthetase Deficiency		Not Available
Gamma-Glutamyltransferase Deficiency		Not Available
5-oxoprolinase deficiency		Not Available
Gamma-glutamyl-transpeptidase deficiency		Not Available

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	29808030	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	27543620	details

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

Not Available

BiGG ID

1446127

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

440103

PDB ID

Not Available

ChEBI ID

50619

Food Biomarker Ontology

Not Available

VMH ID

GLUALA

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

York MJ, Crossley MJ, Hyslop SJ, Fisher ML, Kuchel PW: gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect. Eur J Biochem. 1989 Sep 1;184(1):97-101. [PubMed:2570694 ]
Takahashi T, Kondo T, Ohno H, Minato S, Ohshima T, Mikuni S, Soda K, Taniguchi N: A spectrophotometric method for the determination of gamma-glutamyl cyclotransferase with alanine dehydrogenase in the presence of anthglutin. Biochem Med Metab Biol. 1987 Dec;38(3):311-6. [PubMed:2893631 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Showing metabocard for gamma-Glutamylalanine (HMDB0006248)

MOL for HMDB0006248 (gamma-Glutamylalanine)

3D MOL for HMDB0006248 (gamma-Glutamylalanine)

3D SDF for HMDB0006248 (gamma-Glutamylalanine)

3D-SDF for HMDB0006248 (gamma-Glutamylalanine)

PDB for HMDB0006248 (gamma-Glutamylalanine)

3D PDB for HMDB0006248 (gamma-Glutamylalanine)

SMILES for HMDB0006248 (gamma-Glutamylalanine)

INCHI for HMDB0006248 (gamma-Glutamylalanine)

Structure for HMDB0006248 (gamma-Glutamylalanine)

3D Structure for HMDB0006248 (gamma-Glutamylalanine)

Experimental Collision Cross Sections

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra