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Record Information

Version

5.0

Status

Expected but not Quantified

Creation Date

2012-09-11 22:15:31 UTC

Update Date

2023-02-21 17:25:32 UTC

HMDB ID

HMDB0037015

Secondary Accession Numbers

HMDB37015

Metabolite Identification

Common Name

p-Mentha-1,8-dien-4-ol

Description

p-Mentha-1,8-dien-4-ol belongs to the class of organic compounds known as menthane monoterpenoids. These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes. Based on a literature review a small amount of articles have been published on p-Mentha-1,8-dien-4-ol.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

COMPND    HMDB0037015
HETATM    1  C1  UNL     1      -2.650  -0.133   1.022  1.00  0.00           C  
HETATM    2  C2  UNL     1      -2.021   0.304  -0.050  1.00  0.00           C  
HETATM    3  C3  UNL     1      -2.702   1.267  -0.941  1.00  0.00           C  
HETATM    4  C4  UNL     1      -0.651  -0.176  -0.340  1.00  0.00           C  
HETATM    5  O1  UNL     1      -0.643  -0.922  -1.546  1.00  0.00           O  
HETATM    6  C5  UNL     1      -0.170  -1.154   0.718  1.00  0.00           C  
HETATM    7  C6  UNL     1       1.298  -1.449   0.476  1.00  0.00           C  
HETATM    8  C7  UNL     1       2.053  -0.375   0.367  1.00  0.00           C  
HETATM    9  C8  UNL     1       3.493  -0.474   0.131  1.00  0.00           C  
HETATM   10  C9  UNL     1       1.401   0.943   0.488  1.00  0.00           C  
HETATM   11  C10 UNL     1       0.287   0.966  -0.532  1.00  0.00           C  
HETATM   12  H1  UNL     1      -2.218  -0.843   1.729  1.00  0.00           H  
HETATM   13  H2  UNL     1      -3.668   0.201   1.268  1.00  0.00           H  
HETATM   14  H3  UNL     1      -2.371   2.297  -0.689  1.00  0.00           H  
HETATM   15  H4  UNL     1      -2.460   0.997  -1.993  1.00  0.00           H  
HETATM   16  H5  UNL     1      -3.811   1.229  -0.855  1.00  0.00           H  
HETATM   17  H6  UNL     1      -1.056  -1.825  -1.376  1.00  0.00           H  
HETATM   18  H7  UNL     1      -0.187  -0.684   1.743  1.00  0.00           H  
HETATM   19  H8  UNL     1      -0.760  -2.069   0.656  1.00  0.00           H  
HETATM   20  H9  UNL     1       1.679  -2.461   0.400  1.00  0.00           H  
HETATM   21  H10 UNL     1       3.914  -1.433   0.498  1.00  0.00           H  
HETATM   22  H11 UNL     1       3.660  -0.348  -0.978  1.00  0.00           H  
HETATM   23  H12 UNL     1       3.989   0.404   0.602  1.00  0.00           H  
HETATM   24  H13 UNL     1       2.108   1.773   0.278  1.00  0.00           H  
HETATM   25  H14 UNL     1       0.914   1.060   1.483  1.00  0.00           H  
HETATM   26  H15 UNL     1      -0.200   1.959  -0.464  1.00  0.00           H  
HETATM   27  H16 UNL     1       0.771   0.944  -1.552  1.00  0.00           H  
CONECT    1    2    2   12   13
CONECT    2    3    4
CONECT    3   14   15   16
CONECT    4    5    6   11
CONECT    5   17
CONECT    6    7   18   19
CONECT    7    8    8   20
CONECT    8    9   10
CONECT    9   21   22   23
CONECT   10   11   24   25
CONECT   11   26   27
END

View in JSmol View NMR Assignments View Stereo Labels

Synonyms

Value	Source
4-Methyl-1-(1-methylethenyl)-3-cyclohexen-1-ol, 9ci	HMDB
Limonen-4-ol	HMDB
Limonene-4-ol	HMDB
P-Menth-1,8-dien-4-ol	HMDB

Chemical Formula

C₁₀H₁₆O

Average Molecular Weight

152.2334

Monoisotopic Molecular Weight

152.120115134

IUPAC Name

4-methyl-1-(prop-1-en-2-yl)cyclohex-3-en-1-ol

Traditional Name

4-methyl-1-(prop-1-en-2-yl)cyclohex-3-en-1-ol

CAS Registry Number

3419-02-1

SMILES

CC(=C)C1(O)CCC(C)=CC1

InChI Identifier

InChI=1S/C10H16O/c1-8(2)10(11)6-4-9(3)5-7-10/h4,11H,1,5-7H2,2-3H3

InChI Key

OVKDFILSBMEKLT-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as menthane monoterpenoids. These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Monoterpenoids

Direct Parent

Menthane monoterpenoids

Alternative Parents

Substituents

P-menthane monoterpenoid
Monocyclic monoterpenoid
Tertiary alcohol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Alcohol
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

Not Available

Ontology

Physiological effect

Not Available

Disposition

Biological location

Cellular substructure

Route of exposure

Enteral

Ingestion (HMDB: HMDB0037015)

Source

Endogenous

Endogenous (HMDB: HMDB0037015)

Plant

Plant (HMDB: HMDB0037015)

Animal

Animal (HMDB: HMDB0037015)

Exogenous

Food

Food (HMDB: HMDB0037015)

Fruit

Berry

Blackcurrant (FooDB: FOOD00155)

Citrus

Citrus (FooDB: FOOD00859)

Herb and spice

Spice

Pepper (Spice) (FooDB: FOOD00139)
Caraway (FooDB: FOOD00043)

Herb

Spearmint (FooDB: FOOD00112)

Exogenous (HMDB: HMDB0037015)

Process

Naturally occurring process

Biological process

Chemical reaction

Lipid Peroxidation (HMDB: HMDB0037015)

Biochemical pathway

Metabolic pathway

Fatty Acid Metabolism (HMDB: HMDB0037015)

Lipid metabolism pathway (HMDB: HMDB0037015)

Cellular process

Cell signaling (HMDB: HMDB0037015)

Biochemical process

Lipid transport (HMDB: HMDB0037015)

Role

Biological role

Energy source (HMDB: HMDB0037015)

Industrial application

Manufacturing industry

Material processing agent

Fluid processing agent

Surfactant

Surfactant (HMDB: HMDB0037015)

Physical Properties

State

Not Available

Experimental Molecular Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
Water Solubility	2.41 g/L	ALOGPS
logP	2.42	ALOGPS
logP	2.06	ChemAxon
logS	-1.8	ALOGPS
pKa (Strongest Acidic)	19.23	ChemAxon
pKa (Strongest Basic)	-0.95	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	48.01 m³·mol⁻¹	ChemAxon
Polarizability	17.92 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Collision Cross Sections

Predictor	Adduct Type	CCS Value (Å²)	Reference
DarkChem	[M+H]+	135.024	31661259
DarkChem	[M-H]-	131.121	31661259
DeepCCS	[M+H]+	137.698	30932474
DeepCCS	[M-H]-	134.841	30932474
DeepCCS	[M-2H]-	171.376	30932474
DeepCCS	[M+Na]+	146.91	30932474
AllCCS	[M+H]+	132.7	32859911
AllCCS	[M+H-H2O]+	128.2	32859911
AllCCS	[M+NH4]+	136.9	32859911
AllCCS	[M+Na]+	138.1	32859911
AllCCS	[M-H]-	136.0	32859911
AllCCS	[M+Na-2H]-	137.5	32859911
AllCCS	[M+HCOO]-	139.3	32859911

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
p-Mentha-1,8-dien-4-ol	CC(=C)C1(O)CCC(C)=CC1	1712.4	Standard polar	33892256
p-Mentha-1,8-dien-4-ol	CC(=C)C1(O)CCC(C)=CC1	1159.4	Standard non polar	33892256
p-Mentha-1,8-dien-4-ol	CC(=C)C1(O)CCC(C)=CC1	1185.3	Semi standard non polar	33892256

Derivatized

Derivative Name / Structure	SMILES	Kovats RI Value	Column Type	Reference
p-Mentha-1,8-dien-4-ol,1TMS,isomer #1	C=C(C)C1(O[Si](C)(C)C)CC=C(C)CC1	1266.3	Semi standard non polar	33892256
p-Mentha-1,8-dien-4-ol,1TBDMS,isomer #1	C=C(C)C1(O[Si](C)(C)C(C)(C)C)CC=C(C)CC1	1518.2	Semi standard non polar	33892256

Spectra

GC-MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted GC-MS	Predicted GC-MS Spectrum - p-Mentha-1,8-dien-4-ol GC-MS (Non-derivatized) - 70eV, Positive	splash10-0fs6-9200000000-048b2ee44827ce1e498b	2017-09-01	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - p-Mentha-1,8-dien-4-ol GC-MS (1 TMS) - 70eV, Positive	splash10-05a9-9210000000-88847bf354e0da36d340	2017-10-06	Wishart Lab	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - p-Mentha-1,8-dien-4-ol GC-MS (Non-derivatized) - 70eV, Positive	Not Available	2021-10-12	Wishart Lab	View Spectrum

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 10V, Positive-QTOF	splash10-0f79-0900000000-a10440844c00cc0d5072	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 20V, Positive-QTOF	splash10-0f79-5900000000-5c952e7fb53b1b3f02b5	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 40V, Positive-QTOF	splash10-1000-9200000000-ccfecbd0c2cb9340c6eb	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 10V, Negative-QTOF	splash10-0udi-0900000000-508e815c0bcb012a4ead	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 20V, Negative-QTOF	splash10-0udi-0900000000-e8d6321fdd8e2f054e91	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 40V, Negative-QTOF	splash10-0ka9-6900000000-938c6a3af5362e960d88	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 10V, Negative-QTOF	splash10-0udi-0900000000-c373c9eea3cebf186f53	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 20V, Negative-QTOF	splash10-0udi-0900000000-47d9c4af7c67ba60c0fa	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 40V, Negative-QTOF	splash10-05mo-9600000000-79d222beb25b27be02f4	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 10V, Positive-QTOF	splash10-000j-7900000000-086048a81f9e4dd0bcf4	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 20V, Positive-QTOF	splash10-0007-9200000000-2c802ce763d52fc0a45d	2021-09-22	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - p-Mentha-1,8-dien-4-ol 40V, Positive-QTOF	splash10-0006-9000000000-c05a1ee68b301b9bcb51	2021-09-22	Wishart Lab	View Spectrum

NMR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted 1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum
Predicted 1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	2021-09-25	Wishart Lab	View Spectrum

IR Spectra

Spectrum Type	Description	Deposition Date	Source	View
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)	2023-02-04	FELIX lab	View Spectrum
Predicted IR Spectrum	IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)	2023-02-04	FELIX lab	View Spectrum

Biological Properties

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Pathways

Not Available

Name	SMPDB/PathBank	KEGG

Normal Concentrations

Not Available

Abnormal Concentrations

Not Available

Associated Disorders and Diseases

Disease References

None

Associated OMIM IDs

None

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB015993

KNApSAcK ID

C00010882

Chemspider ID

459676

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

527428

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

Not Available

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
(). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .
Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Showing metabocard for p-Mentha-1,8-dien-4-ol (HMDB0037015)

MOL for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

3D MOL for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

3D SDF for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

3D-SDF for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

PDB for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

3D PDB for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

SMILES for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

INCHI for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

Structure for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

3D Structure for HMDB0037015 (p-Mentha-1,8-dien-4-ol)

Predicted Collision Cross Sections

Predicted Kovats Retention Indices

Underivatized

Derivatized

GC-MS Spectra

MS/MS Spectra

NMR Spectra

IR Spectra