Hmdb loader
Identification
HMDB Protein ID HMDBP00066
Secondary Accession Numbers
  • 5295
Name Acyl-protein thioesterase 2
Synonyms
  1. APT-2
  2. LPL-II
  3. LysoPLA II
  4. Lysophospholipase II
Gene Name LYPLA2
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.
Pathways
  • Glycerophospholipid metabolism
Reactions
Palmitoyl-protein + Water → Palmitic acid + protein details
GO Classification
Biological Process
fatty acid metabolic process
Cellular Component
cytoplasm
Function
catalytic activity
hydrolase activity
Molecular Function
hydrolase activity
Cellular Location
  1. Cytoplasm (Probable)
Gene Properties
Chromosome Location 1
Locus 1p36.11
SNPs LYPLA2
Gene Sequence
>696 bp
ATGTGTGGTAACACCATGTCTGTGCCCCTGCTCACCGATGCTGCCACCGTGTCTGGAGCT
GAGCGGGAAACGGCCGCGGTTATTTTTTTACATGGACTTGGAGACACAGGGCACAGCTGG
GCTGACGCCCTCTCCACCATCCGGCTCCCTCACGTCAAGTACATCTGTCCCCATGCGCCT
AGGATCCCTGTGACCCTCAACATGAAGATGGTGATGCCCTCCTGGTTTGACCTGATGGGG
CTGAGTCCAGATGCCCCAGAGGACGAGGCTGGCATCAAGAAGGCAGCAGAGAACATCAAG
GCCTTGATTGAGCATGAAATGAAGAACGGGATCCCTGCCAATCGAATCGTCCTGGGAGGC
TTTTCACAGGGCGGGGCCCTGTCCCTCTACACGGCCCTCACCTGCCCCCACCCTCTGGCT
GGCATCGTGGCGTTGAGCTGCTGGCTGCCTCTGCACCGGGCCTTCCCCCAGGCAGCTAAT
GGCAGTGCCAAGGACCTGGCCATACTCCAGTGCCATGGGGAGCTGGACCCCATGGTGCCC
GTACGGTTTGGGGCCCTGACGGCTGAGAAGCTCCGGTCTGTTGTCACACCTGCCAGGGTC
CAGTTCAAGACATACCCGGGTGTCATGCACAGCTCCTGTCCTCAGGAGATGGCAGCTGTG
AAGGAATTTCTTGAGAAGCTGCTGCCTCCTGTCTAA
Protein Properties
Number of Residues 231
Molecular Weight 24736.71
Theoretical pI 7.222
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Acyl-protein thioesterase 2
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAP
RIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGG
FSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVP
VRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
GenBank ID Protein 9966764
UniProtKB/Swiss-Prot ID O95372
UniProtKB/Swiss-Prot Entry Name LYPA2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_007260.2
GeneCard ID LYPLA2
GenAtlas ID LYPLA2
HGNC ID HGNC:6738
References
General References
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