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Showing Protein Aldose reductase (HMDBP00088)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 24 metabolites
Identification
HMDB Protein ID HMDBP00088
Secondary Accession Numbers
  • 5320
  • HMDBP04365
Name Aldose reductase
Synonyms
  1. AR
  2. Aldehyde reductase
  3. Aldo-keto reductase family 1 member B1
Gene Name AKR1B1
Protein Type Unknown
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pathways
  • D-glyceric acidura
  • Dopa-responsive dystonia
  • Familial lipoprotein lipase deficiency
  • Fructose and mannose metabolism
  • Fructose and mannose metabolism
  • Fructose intolerance, hereditary
  • Fructosuria
  • Galactose metabolism
  • Galactose Metabolism
  • Galactosemia
  • Glycerol Kinase Deficiency
  • Glycerolipid metabolism
  • Glycerolipid Metabolism
  • Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency
  • Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps)
  • Hyperphenylalaninemia due to dhpr-deficiency
  • Leigh Syndrome
  • Pentose and glucuronate interconversions
  • Primary hyperoxaluria II, PH2
  • Pterine Biosynthesis
  • Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
  • Pyruvate Dehydrogenase Complex Deficiency
  • Pyruvate kinase deficiency
  • Pyruvate metabolism
  • Pyruvate metabolism
  • Segawa syndrome
  • Sepiapterin reductase deficiency
Reactions
Glycerol + NAD(P)(+) → Glyceraldehyde + NAD(P)H details
Glycerol + NAD → Glyceraldehyde + NADH + Hydrogen Ion details
Glycerol + NADP → Glyceraldehyde + NADPH + Hydrogen Ion details
beta-D-Galactose + NADH + Hydrogen Ion → Galactitol + NAD details
beta-D-Galactose + NADPH + Hydrogen Ion → Galactitol + NADP details
D-Xylitol + NADP → D-Xylose + NADPH + Hydrogen Ion details
L-Arabitol + NAD → L-Arabinose + NADH + Hydrogen Ion details
L-Arabitol + NADP → L-Arabinose + NADPH + Hydrogen Ion details
Sorbitol + NADP → alpha-D-Glucose + NADPH + Hydrogen Ion details
Lactaldehyde + NAD → Pyruvaldehyde + NADH + Hydrogen Ion details
Propylene glycol + NADP → Lactaldehyde + NADPH + Hydrogen Ion details
GO Classification
Biological Process
small molecule metabolic process
C21-steroid hormone biosynthetic process
response to stress
daunorubicin metabolic process
doxorubicin metabolic process
carbohydrate metabolic process
Cellular Component
cytosol
nucleus
extracellular space
Function
catalytic activity
oxidoreductase activity
Molecular Function
electron carrier activity
alditol:NADP+ 1-oxidoreductase activity
glyceraldehyde oxidoreductase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 7
Locus 7q35
SNPs AKR1B1
Gene Sequence 
>951 bp
ATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACC
TGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTAC
CGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAG
GAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGG
TGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTG
AAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAG
GAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGAC
ACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCC
AACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCT
GCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGC
CAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGG
GCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAG
CACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTG
ATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAA
CTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCC
TTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGA
Protein Properties
Number of Residues 316
Molecular Weight 35853.125
Theoretical pI 6.982
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Aldose reductase
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
GenBank ID Protein 2687578
UniProtKB/Swiss-Prot ID P15121
UniProtKB/Swiss-Prot Entry Name ALDR_HUMAN
PDB IDs
GenBank Gene ID AF032455
GeneCard ID AKR1B1
GenAtlas ID AKR1B1
HGNC ID HGNC:381
References
General References
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  28. Steuber H, Zentgraf M, La Motta C, Sartini S, Heine A, Klebe G: Evidence for a novel binding site conformer of aldose reductase in ligand-bound state. J Mol Biol. 2007 May 25;369(1):186-97. Epub 2007 Mar 15. [PubMed:17418233 ]
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