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Identification
HMDB Protein ID HMDBP00095
Secondary Accession Numbers
  • 5327
Name Low molecular weight phosphotyrosine protein phosphatase
Synonyms
  1. Adipocyte acid phosphatase
  2. LMW-PTP
  3. LMW-PTPase
  4. Low molecular weight cytosolic acid phosphatase
  5. Red cell acid phosphatase 1
Gene Name ACP1
Protein Type Enzyme
Biological Properties
General Function Involved in acid phosphatase activity
Specific Function Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Pathways
  • Adherens junction
  • Riboflavin metabolism
  • Riboflavin Metabolism
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
A phosphate monoester + Water → an alcohol + Phosphate details
Flavin mononucleotide + Water → Riboflavin + Phosphate details
GO Classification
Biological Process
synaptic transmission
Cellular Component
cytoplasm
nucleus
internal side of plasma membrane
Component
cell part
intracellular part
cytoplasm
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
acid phosphatase activity
Molecular Function
acid phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 2
Locus 2p25
SNPs ACP1
Gene Sequence
>477 bp
ATGGCGGAACAGGCTACCAAGTCCGTGCTGTTTGTGTGTCTGGGTAACATTTGTCGATCA
CCCATTGCAGAAGCAGTTTTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGG
AGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCTGACTACCGAGGG
CAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGATTACCAAA
GAAGATTTTGCCACATTTGATTATATACTATGTATGGATGAAAGCAATCTGAGAGATTTG
AATAGAAAAAGTAATCAAGTTAAAACCTGCAAAGCTAAAATTGAACTACTTGGGAGCTAT
GATCCACAAAAACAACTTATTATTGAAGATCCCTATTATGGGAATGACTCTGACTTTGAG
ACGGTGTACCAGCAGTGTGTCAGGTGCTGCAGAGCGTTCTTGGAGAAGGCCCACTGA
Protein Properties
Number of Residues 158
Molecular Weight 18042.315
Theoretical pI 6.737
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Low molecular weight phosphotyrosine protein phosphatase
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P24666
UniProtKB/Swiss-Prot Entry Name PPAC_HUMAN
PDB IDs
GenBank Gene ID M83653
GeneCard ID ACP1
GenAtlas ID ACP1
HGNC ID HGNC:122
References
General References
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  4. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
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  6. Dissing J, Johnsen AH, Sensabaugh GF: Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele. J Biol Chem. 1991 Nov 5;266(31):20619-25. [PubMed:1939112 ]
  7. Dissing J, Johnsen AH: Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles. Biochim Biophys Acta. 1992 Jun 24;1121(3):261-8. [PubMed:1627603 ]
  8. Wo YY, McCormack AL, Shabanowitz J, Hunt DF, Davis JP, Mitchell GL, Van Etten RL: Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase. J Biol Chem. 1992 May 25;267(15):10856-65. [PubMed:1587862 ]
  9. Bryson GL, Massa H, Trask BJ, Van Etten RL: Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1. Genomics. 1995 Nov 20;30(2):133-40. [PubMed:8586411 ]
  10. Shekels LL, Smith AJ, Van Etten RL, Bernlohr DA: Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase. Protein Sci. 1992 Jun;1(6):710-21. [PubMed:1304913 ]
  11. Tailor P, Gilman J, Williams S, Couture C, Mustelin T: Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132. J Biol Chem. 1997 Feb 28;272(9):5371-4. [PubMed:9038134 ]
  12. Tailor P, Gilman J, Williams S, Mustelin T: A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing. Eur J Biochem. 1999 Jun;262(2):277-82. [PubMed:10336608 ]
  13. Sensabaugh GF, Lazaruk KA: A TaqI site identifies the *A allele at the ACP1 locus. Hum Mol Genet. 1993 Jul;2(7):1079. [PubMed:8364553 ]
  14. Nicolas G, Fournier CM, Galand C, Malbert-Colas L, Bournier O, Kroviarski Y, Bourgeois M, Camonis JH, Dhermy D, Grandchamp B, Lecomte MC: Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain. Mol Cell Biol. 2002 May;22(10):3527-36. [PubMed:11971983 ]
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  16. Zhang M, Stauffacher CV, Lin D, Van Etten RL: Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. J Biol Chem. 1998 Aug 21;273(34):21714-20. [PubMed:9705307 ]