HMDB0001248 | FAD | 146-14-5 | | C27H33N9O15P2 | 785.5497 785.157134455 | Not Available |
HMDB0003178 | Heme | 14875-96-8 | | C34H32FeN4O4 | 616.487 616.177297665 | Not Available |
HMDB0014624 | Raloxifene | 84449-90-1 | | C28H27NO4S | 473.583 473.166079047 | - Obach RS: Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97. [PubMed:14709625 ]
- Obach RS, Huynh P, Allen MC, Beedham C: Human liver aldehyde oxidase: inhibition by 239 drugs. J Clin Pharmacol. 2004 Jan;44(1):7-19. [PubMed:14681337 ]
- Sahi J, Khan KK, Black CB: Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human. Drug Metab Lett. 2008 Aug;2(3):176-83. [PubMed:19356090 ]
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HMDB0014703 | Methotrexate | 59-05-2 | | C20H22N8O5 | 454.4393 454.171315854 | - Zientek M, Jiang Y, Youdim K, Obach RS: In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010 Aug;38(8):1322-7. doi: 10.1124/dmd.110.033555. Epub 2010 May 5. [PubMed:20444863 ]
- Baggott JE, Morgan SL: Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation. Arthritis Rheum. 2009 Aug;60(8):2257-61. doi: 10.1002/art.24685. [PubMed:19644884 ]
- Jordan CG, Rashidi MR, Laljee H, Clarke SE, Brown JE, Beedham C: Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. J Pharm Pharmacol. 1999 Apr;51(4):411-8. [PubMed:10385213 ]
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HMDB0014570 | Famciclovir | 104227-87-4 | | C14H19N5O4 | 321.3318 321.143704121 | - Rashidi MR, Smith JA, Clarke SE, Beedham C: In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. Drug Metab Dispos. 1997 Jul;25(7):805-13. [PubMed:9224775 ]
- Al-Salmy HS: Inter-strain variability in aldehyde oxidase activity in the mouse. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Jul;132(3):341-7. [PubMed:12161167 ]
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HMDB0060463 | Citalopram propionic acid | | | C18H14FNO3 | 311.3071 311.095771524 | Not Available |
HMDB0015097 | Zaleplon | 151319-34-5 | | C17H15N5O | 305.3339 305.127660127 | - Obach RS: Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97. [PubMed:14709625 ]
- Lake BG, Ball SE, Kao J, Renwick AB, Price RJ, Scatina JA: Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica. 2002 Oct;32(10):835-47. [PubMed:12419014 ]
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HMDB0060462 | Citalopram aldehyde | | | C18H14FNO2 | 295.3077 295.100856902 | Not Available |
HMDB0014627 | Brimonidine | 59803-98-4 | | C11H10BrN5 | 292.135 291.011957992 | - Acheampong AA, Chien DS, Lam S, Vekich S, Breau A, Usansky J, Harcourt D, Munk SA, Nguyen H, Garst M, Tang-Liu D: Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase. Xenobiotica. 1996 Oct;26(10):1035-55. [PubMed:8905918 ]
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HMDB0030788 | Citrusal | 5980-07-4 | | C15H16O4 | 260.2851 260.104859 | Not Available |
HMDB0247053 | 6-Deoxypenciclovir | | | C10H15N5O2 | 237.263 237.122574743 | Not Available |
HMDB0015045 | Zonisamide | 68291-97-4 | | C8H8N2O3S | 212.226 212.025562822 | - Sugihara K, Kitamura S, Tatsumi K: Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide. Drug Metab Dispos. 1996 Feb;24(2):199-202. [PubMed:8742231 ]
- Kitamura S, Ohashi KNK, Sugihara K, Hosokawa R, Akagawa Y, Ohta S: Extremely high drug-reductase activity based on aldehyde oxidase in monkey liver. Biol Pharm Bull. 2001 Jul;24(7):856-9. [PubMed:11456132 ]
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HMDB0000763 | 5-Hydroxyindoleacetic acid | 54-16-0 | | C10H9NO3 | 191.1834 191.058243159 | Not Available |
HMDB0000017 | 4-Pyridoxic acid | 82-82-6 | | C8H9NO4 | 183.1614 183.053157781 | - Stanulovic M, Jeremic V, Leskovac V, Chaykin S: New pathway of conversion of pyridoxal to 4-pyridoxic acid. Enzyme. 1976;21(4):357-69. [PubMed:939227 ]
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HMDB0001046 | Cotinine | 486-56-6 | | C10H12N2O | 176.2151 176.094963016 | Not Available |
HMDB0004073 | 5-Hydroxyindoleacetaldehyde | 1892-21-3 | | C10H9NO2 | 175.184 175.063328537 | Not Available |
HMDB0001892 | Menadione | 58-27-5 | | C11H8O2 | 172.18 172.0524295 | - Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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HMDB0001545 | Pyridoxal | 66-72-8 | | C8H9NO3 | 167.162 167.058243159 | Not Available |
HMDB0000152 | Gentisic acid | 490-79-9 | | C7H6O4 | 154.121 154.026608673 | Not Available |
HMDB0004193 | Nudifloramide | 701-44-0 | | C7H8N2O2 | 152.1506 152.05857751 | Not Available |
HMDB0004194 | N1-Methyl-4-pyridone-3-carboxamide | 769-49-3 | | C7H8N2O2 | 152.1506 152.05857751 | Not Available |
HMDB0001263 | Allysine | 6665-12-9 | | C6H11NO3 | 145.1564 145.073893223 | Not Available |
HMDB0004062 | Gentisate aldehyde | 1194-98-5 | | C7H6O3 | 138.1207 138.031694058 | Not Available |
HMDB0000699 | 1-Methylnicotinamide | 3106-60-3 | | C7H9N2O | 137.1592 137.07148792 | Not Available |
HMDB0014581 | Allopurinol | 315-30-0 | | C5H4N4O | 136.1115 136.03851077 | - Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. [PubMed:8216357 ]
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