Hmdb loader
Identification
HMDB Protein ID HMDBP00200
Secondary Accession Numbers
  • 5432
  • HMDBP03462
Name NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Synonyms
  1. CI-ASHI
  2. Complex I-ASHI
  3. NADH-ubiquinone oxidoreductase ASHI subunit
Gene Name NDUFB8
Protein Type Enzyme
Biological Properties
General Function Involved in NADH dehydrogenase activity
Specific Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Pathways Not Available
Reactions Not Available
GO Classification
Component
mitochondrion
cell part
membrane part
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
mitochondrial membrane part
mitochondrial respiratory chain complex i
Function
catalytic activity
nadh dehydrogenase activity
nadh dehydrogenase (quinone) activity
nadh dehydrogenase (ubiquinone) activity
oxidoreductase activity
oxidoreductase activity, acting on nadh or nadph
Process
metabolic process
generation of precursor metabolites and energy
electron transport chain
respiratory electron transport chain
cellular metabolic process
mitochondrial electron transport, nadh to ubiquinone
Cellular Location
  1. Single-pass membrane protein
  2. Mitochondrion inner membrane
  3. Matrix side
Gene Properties
Chromosome Location Chromosome:1
Locus 10q24.31
SNPs NDUFB8
Gene Sequence
>561 bp
ATGGCGGTGGCCAGGGCCGGGGTCTTGGGAGTCCAGTGGCTGCAAAGGGCATCCCGGAAC
GTGATGCCGCTGGGCGCACGGACAGCCTCCCACATGACCAAGGACATGTTCCCGGGGCCC
TATCCTAGGACCCCAGAAGAACGGGCCGCCGCCGCCAAGAAGTATAATATGCGTGTGGAA
GACTACGAACCTTACCCGGATGATGGCATGGGGTATGGCGACTACCCGAAGCTCCCTGAC
CGCTCACAGCATGAGAGAGATCCATGGTATAGCTGGGACCAGCCGGGCCTGAGGTTGAAC
TGGGGTGAACCGATGCACTGGCACCTAGACATGTACAACAGGAACCGTGTGGATACATCC
CCCACACCTGTTTCTTGGCATGTCATGTGTATGCAGCTCTTCGGTTTCCTGGCTTTCATG
ATATTCATGTGCTGGGTGGGGGACGTGTACCCTGTCTACCAGCCTGTGGGACCAAAGCAG
TATCCTTACAATAATCTGTACCTGGAACGAGGCGGTGATCCCTCCAAAGAACCAGAGCGG
GTGGTTCACTATGAGATCTGA
Protein Properties
Number of Residues 186
Molecular Weight 21765.7
Theoretical pI 6.79
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 133-153
Protein Sequence
>NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
MAVARAGVLGVQWLQRASRNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVE
DYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTS
PTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPER
VVHYEI
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95169
UniProtKB/Swiss-Prot Entry Name NDUB8_HUMAN
PDB IDs Not Available
GenBank Gene ID AF044958
GeneCard ID NDUFB8
GenAtlas ID NDUFB8
HGNC ID HGNC:7703
References
General References
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