Hmdb loader
Identification
HMDB Protein ID HMDBP00227
Secondary Accession Numbers
  • 5459
Name Lysosomal acid lipase/cholesteryl ester hydrolase
Synonyms
  1. Acid cholesteryl ester hydrolase
  2. Cholesteryl esterase
  3. LAL
  4. Lipase A
  5. Sterol esterase
Gene Name LIPA
Protein Type Enzyme
Biological Properties
General Function Involved in lipid metabolic process
Specific Function Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Pathways
  • 27-Hydroxylase Deficiency
  • Alendronate Action Pathway
  • Atorvastatin Action Pathway
  • Cerebrotendinous Xanthomatosis (CTX)
  • Cerivastatin Action Pathway
  • CHILD Syndrome
  • Cholesteryl ester storage disease
  • Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)
  • Congenital Bile Acid Synthesis Defect Type II
  • Congenital Bile Acid Synthesis Defect Type III
  • Desmosterolosis
  • Familial Hypercholanemia (FHCA)
  • Fluvastatin Action Pathway
  • Hyper-IgD syndrome
  • Hypercholesterolemia
  • Ibandronate Action Pathway
  • Lovastatin Action Pathway
  • Lysosomal Acid Lipase Deficiency (Wolman Disease)
  • Lysosome
  • Mevalonic aciduria
  • Pamidronate Action Pathway
  • Pravastatin Action Pathway
  • Primary bile acid biosynthesis
  • Risedronate Action Pathway
  • Rosuvastatin Action Pathway
  • Simvastatin Action Pathway
  • Smith-Lemli-Opitz Syndrome (SLOS)
  • Steroid biosynthesis
  • Steroid Biosynthesis
  • Wolman disease
  • Zellweger Syndrome
  • Zoledronate Action Pathway
Reactions
A steryl ester + Water → a sterol + a fatty acid details
Cholesterol ester + Water → Cholesterol + Fatty acid details
GO Classification
Biological Process
homeostasis of number of cells within a tissue
sterol metabolic process
tissue remodeling
cell proliferation
lipid catabolic process
inflammatory response
fatty acid metabolic process
cytokine production
cell morphogenesis
lung development
Cellular Component
lysosome
Molecular Function
sterol esterase activity
lipase activity
Process
metabolic process
primary metabolic process
lipid metabolic process
Cellular Location
  1. Lysosome
Gene Properties
Chromosome Location 10
Locus 10q23.2-q23.3
SNPs LIPA
Gene Sequence
>1200 bp
ATGAAAATGCGGTTCTTGGGGTTGGTGGTCTGTTTGGTTCTCTGGACCCTGCATTCTGAG
GGGTCTGGAGGGAAACTGACAGCTGTGGATCCTGAAACAAACATGAATGTGAGTGAAATT
ATCTCTTACTGGGGATTCCCTAGTGAGGAATACCTAGTTGAGACAGAAGATGGATATATT
CTGTGCCTTAACCGAATTCCTCATGGGAGGAAGAACCATTCTGACAAAGGTCCCAAACCA
GTTGTCTTCCTGCAACATGGCTTGCTGGCAGATTCTAGTAACTGGGTCACAAACCTTGCC
AACAGCAGCCTGGGCTTCATTCTTGCTGATGCTGGTTTTGACGTGTGGATGGGCAACAGC
AGAGGAAATACCTGGTCTCGGAAACATAAGACACTCTCAGTTTCTCAGGATGAATTCTGG
GCTTTCAGTTATGATGAGATGGCAAAATATGACCTACCAGCTTCCATTAACTTCATTCTG
AATAAAACTGGCCAAGAACAAGTGTATTATGTGGGTCATTCTCAAGGCACCACTATAGGT
TTTATAGCATTTTCACAGATCCCTGAGCTGGCTAAAAGGATTAAAATGTTTTTTGCCCTG
GGTCCTGTGGCTTCCGTCGCCTTCTGTACTAGCCCTATGGCCAAATTAGGACGATTACCA
GATCATCTCATTAAGGACTTATTTGGAGACAAAGAATTTCTTCCCCAGAGTGCGTTTTTG
AAGTGGCTGGGTACCCACGTTTGCACTCATGTCATACTGAAGGAGCTCTGTGGAAATCTC
TGTTTTCTTCTGTGTGGATTTAATGAGAGAAATTTAAATATGTCTAGAGTGGATGTATAT
ACAACACATTCTCCTGCTGGAACTTCTGTGCAAAACATGTTACACTGGAGCCAGGCTGTT
AAATTCCAAAAGTTTCAAGCCTTTGACTGGGGAAGCAGTGCCAAGAATTATTTTCATTAC
AACCAGAGTTATCCTCCCACATACAATGTGAAGGACATGCTTGTGCCGACTGCAGTCTGG
AGCGGGGGTCACGACTGGCTTGCAGATGTCTACGACGTCAATATCTTACTGACTCAGATC
ACCAACTTGGTGTTCCATGAGAGCATTCCGGAATGGGAGCATCTTGACTTCATTTGGGGC
CTGGATGCCCCTTGGAGGCTTTATAATAAAATTATTAATCTAATGAGGAGATATCAGTGA
Protein Properties
Number of Residues 399
Molecular Weight 45418.71
Theoretical pI 6.914
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Lysosomal acid lipase/cholesteryl ester hydrolase
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYI
LCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNS
RGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIG
FIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFL
KWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAV
KFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQI
TNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
GenBank ID Protein 62897079
UniProtKB/Swiss-Prot ID P38571
UniProtKB/Swiss-Prot Entry Name LICH_HUMAN
PDB IDs Not Available
GenBank Gene ID AK222760
GeneCard ID LIPA
GenAtlas ID LIPA
HGNC ID HGNC:6617
References
General References
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  5. Anderson RA, Sando GN: Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases. J Biol Chem. 1991 Nov 25;266(33):22479-84. [PubMed:1718995 ]
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