Human Metabolome Database: Showing Protein Sialidase-3 (HMDBP00319)

Identification Biological properties Gene properties Protein properties External links References XML Show 62 metabolites

Identification
HMDB Protein ID	HMDBP00319
Secondary Accession Numbers	5555
Name	Sialidase-3
Synonyms	Ganglioside sialidase Membrane sialidase N-acetyl-alpha-neuraminidase 3
Gene Name	NEU3
Protein Type	Enzyme
Biological Properties
General Function	Involved in exo-alpha-sialidase activity
Specific Function	Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates
Pathways	Fabry disease Gaucher Disease Globoid Cell Leukodystrophy Krabbe disease Metachromatic Leukodystrophy (MLD) Starch and sucrose metabolism
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Peripheral membrane protein Membrane
Gene Properties
Chromosome Location	Chromosome:1
Locus	11q13.5
SNPs	NEU3
Gene Sequence	>1287 bp ATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGA GGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCC TTTGCAGAGAAGCGTTCCACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGA GGGTTGAGGATTGGGCAGTTGGTACAGTGGGGGCCCCTGAAGCCACTGATGGAAGCCACA CTACCGGGGCATCGGACCATGAACCCCTGTCCTGTATGGGAGCAGAAGAGTGGTTGTGTG TTCCTGTTCTTCATCTGTGTGCGGGGCCATGTCACAGAGCGTCAACAGATTGTGTCAGGC AGGAATGCTGCCCGCCTTTGCTTCATCTACAGTCAGGATGCTGGATGTTCATGGAGTGAG GTGAGGGACTTGACTGAGGAGGTCATTGGCTCAGAGCTGAAGCACTGGGCCACATTTGCT GTGGGCCCAGGTCATGGCATCCAGCTGCAGTCAGGGAGACTGGTCATCCCTGCGTATACC TACTACATCCCTTCCTGGTTCTTTTGCTTCCAGCTACCATGTAAAACCAGGCCTCATTCT CTGATGATCTACAGTGATGACCTAGGGGTCACATGGCACCATGGTAGACTCATTAGGCCC ATGGTTACAGTAGAATGTGAAGTGGCAGAGGTGACTGGGAGGGCTGGCCACCCTGTGCTA TATTGCAGTGCCCGGACACCAAACAGGTGCCGGGCAGAGGCGCTCAGCACTGACCATGGT GAAGGCTTTCAGAGACTGGCCCTGAGTCGACAGCTCTGTGAGCCCCCACATGGTTGCCAA GGGAGTGTGGTAAGTTTCCGGCCCCTGGAGATCCCACATAGGTGCCAGGACTCTAGCAGC AAAGATGCACCCACCATTCAGCAGAGCTCTCCAGGCAGTTCACTGAGGCTGGAGGAGGAA GCTGGAACACCGTCAGAATCATGGCTCTTGTACTCACACCCAACCAGTAGGAAACAGAGG GTTGACCTAGGTATCTATCTCAACCAGACCCCCTTGGAGGCTGCCTGCTGGTCCCGCCCC TGGATCTTGCACTGTGGGCCCTGTGGCTACTCTGATCTGGCTGCTCTGGAGGAGGAGGGC TTGTTTGGGTGTTTGTTTGAATGTGGGACCAAGCAAGAGTGTGAGCAGATTGCCTTCCGC CTGTTTACACACCGGGAGATCCTGAGTCACCTGCAGGGGGACTGCACCAGCCCTGGTAGG AACCCAAGCCAATTCAAAAGCAATTAA
Protein Properties
Number of Residues	428
Molecular Weight	48251.5
Theoretical pI	7.17
Pfam Domain Function	Not Available
Signals	None
Transmembrane Regions	None
Protein Sequence	>Sialidase-3 MEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRR GLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSG RNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYT YYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVL YCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSS KDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRP WILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGR NPSQFKSN
External Links
GenBank ID Protein	5631293
UniProtKB/Swiss-Prot ID	Q9UQ49
UniProtKB/Swiss-Prot Entry Name	NEUR3_HUMAN
PDB IDs	Not Available
GenBank Gene ID	AB008185
GeneCard ID	NEU3
GenAtlas ID	NEU3
HGNC ID	HGNC:7760
References
General References	Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ] Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T: Cloning, expression, and chromosomal mapping of a human ganglioside sialidase. Biochem Biophys Res Commun. 1999 Jul 22;261(1):21-7. [PubMed:10405317 ] Monti E, Bassi MT, Papini N, Riboni M, Manzoni M, Venerando B, Croci G, Preti A, Ballabio A, Tettamanti G, Borsani G: Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Biochem J. 2000 Jul 1;349(Pt 1):343-51. [PubMed:10861246 ]