Hmdb loader
Identification
HMDB Protein ID HMDBP00417
Secondary Accession Numbers
  • 5654
Name Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
Synonyms
  1. 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
  2. DHHB methyltransferase
  3. DHHB-MT
  4. DHHB-MTase
  5. Dihydroxyhexaprenylbenzoate methyltransferase
  6. 2-polyprenyl-6-hydroxyphenyl methylase
  7. 3-demethylubiquinone-10 3-methyltransferase
Gene Name COQ3
Protein Type Unknown
Biological Properties
General Function Involved in methyltransferase activity
Specific Function Not Available
Pathways
  • Ubiquinone and other terpenoid-quinone biosynthesis
  • ubiquinone biosynthesis
  • Ubiquinone Biosynthesis
Reactions
S-Adenosylmethionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate → S-Adenosylhomocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate details
S-Adenosylmethionine + 3-demethylubiquinone-n → S-Adenosylhomocysteine + ubiquinone-n details
S-Adenosylmethionine + 3-(all-trans-polyprenyl)benzene-1,2-diol → S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol details
2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine → Ubiquinone 6 + S-Adenosylhomocysteine details
S-Adenosylmethionine + 3-Hexaprenyl-4,5-Dihydroxybenzoic acid → S-Adenosylhomocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid + Hydrogen Ion details
S-Adenosylmethionine + 3-Demethylubiquinone-9 → S-Adenosylhomocysteine + Coenzyme Q9 details
3-Polyprenyl-4,5-dihydroxybenzoate + S-Adenosylmethionine → 3-Polyprenyl-4-hydroxy-5-methoxybenzoate + S-Adenosylhomocysteine details
2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine → Ubiquinone-2 + S-Adenosylhomocysteine details
GO Classification
Biological Process
glycerol metabolic process
ubiquinone biosynthetic process
Cellular Component
mitochondrial matrix
Function
catalytic activity
transferase activity
c-methyltransferase activity
quinone cofactor methyltransferase activity
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
3-demethylubiquinone-9 3-O-methyltransferase activity
hexaprenyldihydroxybenzoate methyltransferase activity
O-methyltransferase activity
Process
metabolic process
cellular metabolic process
oxidoreduction coenzyme metabolic process
ubiquinone metabolic process
ubiquinone biosynthetic process
cofactor metabolic process
coenzyme metabolic process
Cellular Location
  1. Mitochondrion matrix (Probable)
Gene Properties
Chromosome Location 6
Locus 6q16.2
SNPs COQ3
Gene Sequence
>1110 bp
ATGTGGAGTGGCCGTAAGCTGGGCTCCTCCGGGGGTTGGTTTTTAAGAGTGCTGGGGCCT
GGAGGCTGTAATACAAAAGCTGCGCGTCCCTTAATTTCCTCGGCGGTTTATGTGAAGAAC
CAGCTCAGTGGGACTCTACAGATTAAACCAGGGGTTTTCAATGAATACAGAACCATATGG
TTCAAATCCTACAGGACGATCTTTTCCTGTTTGAACAGAATAAAGAGTTTCAGGTACCCT
TGGGCGAGACTGTACAGTACTTCCCAAACCACTGTCGACAGCGGTGAGGTAAAAACCTTC
TTGGCCCTGGCTCACAAATGGTGGGATGAACAAGGAGTATATGCACCTCTTCATTCCATG
AATGACCTGAGGGTGCCATTTATTAGGGACAATCTTCTGAAAACAATTCCTAATCACCAG
CCAGGAAAACCTTTGTTGGGGATGAAGATTCTTGACGTTGGCTGTGGTGGTGGGCTGTTA
ACTGAACCTCTAGGGCGGCTTGGGGCTTCAGTTATTGGAATCGACCCTGTGGATGAGAAC
ATTAAAACAGCACAATGCCATAAATCATTTGATCCAGTCCTGGATAAGAGAATAGAGTAC
AGAGTGTGTTCCCTGGAAGAGATTGTGGAAGAGACTGCAGAAACATTTGATGCTGTTGTA
GCTTCTGAAGTTGTAGAACATGTGATTGATCTAGAAACATTTTTACAGTGCTGCTGTCAA
GTGTTAAAACCCGGTGGTTCTTTATTCATTACTACAATCAACAAAACACAACTTTCCTAT
GCCTTGGGAATTGTTTTTTCAGAGCAAATTGCAAGTATTGTACCAAAAGGTACTCATACA
TGGGAGAAGTTTGTTTCACCTGAAACACTAGAGAGCATTCTGGAATCAAATGGTCTGTCA
GTTCAAACAGTGGTAGGAATGCTCTATAACCCCTTCTCAGGTTACTGGCATTGGAGTGAA
AATACCAGCCTTAACTATGCAGCTTATGCTGTGAAATCCAGGGTCCAGGAACACCCAGCC
TCTGCTGAGTTTGTTTTAAAGGGAGAAACAGAAGAGCTCCAAGCTAATGCCTGCACCAAT
CCAGCTGTGCATGAAAAGCTGAAGAAATGA
Protein Properties
Number of Residues 369
Molecular Weight 41053.76
Theoretical pI 7.422
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
MWSGRKLGSSGGWFLRVLGPGGCNTKAARPLISSAVYVKNQLSGTLQIKPGVFNEYRTIW
FKSYRTIFSCLNRIKSFRYPWARLYSTSQTTVDSGEVKTFLALAHKWWDEQGVYAPLHSM
NDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDEN
IKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQ
VLKPGGSLFITTINKTQLSYALGIVFSEQIAGIVPKGTHTWEKFVSPETLESILESNGLS
VQTVVGMLYNPFSGYWHWSENTSLNYAAHAVKSRVQEHPASAEFVLKGETEELQANACTN
PAVHEKLKK
GenBank ID Protein 118600965
UniProtKB/Swiss-Prot ID Q9NZJ6
UniProtKB/Swiss-Prot Entry Name COQ3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_017421.3
GeneCard ID COQ3
GenAtlas ID COQ3
HGNC ID HGNC:18175
References
General References
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