Hmdb loader
Identification
HMDB Protein ID HMDBP00537
Secondary Accession Numbers
  • 5788
Name Acyloxyacyl hydrolase
Synonyms
  1. Acyloxyacyl hydrolase large subunit
  2. Acyloxyacyl hydrolase small subunit
Gene Name AOAH
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides
Pathways Not Available
Reactions Not Available
GO Classification
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
Process
metabolic process
primary metabolic process
lipid metabolic process
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:7
Locus 7p14-p12
SNPs AOAH
Gene Sequence
>1728 bp
ATGCAGTCCCCCTGGAAAATCCTTACGGTGGCGCCTCTATTCTTGCTCCTGTCTCTTCAG
TCCTCAGCCTCTCCAGCCAACGATGACCAGTCCAGGCCCAGCCTCTCGAATGGGCACACC
TGTGTAGGGTGTGTGCTGGTGGTGTCTGTAATAGAACAGCTTGCTCAAGTTCACAACTCG
ACGGTCCAGGCCTCGATGGAGAGACTGTGCAGCTACCTGCCTGAAAAACTGTTCTTGAAA
ACCACCTGCTATTTAGTCATTGACAAGTTTGGATCAGACATCATAAAACTGCTTAGCGCA
GATATGAATGCTGATGTGGTATGTCACACTCTGGAGTTTTGTAAACAGAACACTGGCCAA
CCATTGTGTCATCTCTACCCTCTTCCCAAGGAGACATGGAAATTTACACTACAGAAGGCA
AGACAAATTGTCAAGAAGTCCCCGATTCTGAAATATTCTAGAAGTGGTTCTGACATTTGT
TCACTCCCGGTTTTGGCCAAGATCTGCCAGAAAATTAAATTAGCTATGGAACAGTCTGTG
CCATTCAAAGATGTGGATTCAGACAAATACAGCGTTTTCCCAACACTGCGGGGCTATCAC
TGGCGGGGGAGAGACTGTAATGACAGCGACGAGTCAGTGTACCCAGGTAGAAGGCCGAAC
AACTGTGATGTCCATCAGGATTCAAACTGTAATGGCATTTGGGGTGTCGATCCAAAAGAT
GGAGTTCCATATGAGAAGAAATTCTGTGAAGGTTCACAGCCCAGGGGAATCATTTTGCTG
GGAGACTCAGCTGGGGCTCATTTTCACATCTCTCCTGAATGGATCACAGCGTCGCAGATG
TCTTTGAACTCTTTCATCAATCTACCAACAGCCCTTACCAACGAGCTTGACTGGCCCCAA
CTCTCTGGTGCTACAGGATTTCTGGACTCCACTGTTGGAATTAAAGAAAAATCTATTTAC
CTTCGCTTATGGAAAAGAAACCACTGTAATCACAGGGACTACCAGAATATTTCAAGAAAT
GGTGCATCTTCCCGAAACCTGAAGAAATTTATAGAAAGCTTGTCTAGAAACAAGGTGTTG
GACTATCCCGCCATCGTTATATATGCCATGATTGGAAATGATGTCTGCAGTGGGAAGAGT
GACCCAGTCCCAGCCATGACCACTCCTGAGAAACTCTACTCCAACGTCATGCAGACTCTG
AAGCATCTAAATTCCCACCTGCCCAATGGCAGCCATGTTATTTTGTATGGCTTACCAGAT
GGAACCTTTCTCTGGGATAATTTGCACAACAGATATCATCCTCTCGGCCAGCTAAATAAA
GACATGACCTATGCGCAGTTGTACTCCTTCCTGAACTGCCTCCAGGTCAGCCCCTGCCAC
GGCTGGATGTCTTCCAACAAGACGTTGCGGACTCTCACTTCAGAGAGAGCAGAGCAACTC
TCCAACACACTGAAAAAAATTGCAGCCAGTGAGAAATTTACAAACTTCAATCTTTTCTAC
ATGGATTTTGCCTTCCATGAAATCATACAGGAGTGGCAGAAGAGAGGCGGACAGCCCTGG
CAGCTCATCGAGCCCGTGGATGGATTCCACCCCAACGAGGTGGCTTTGCTGTTGTTGGCG
GATCATTTCTGGAAAAAGGTGCAGCTCCAGTGGCCCCAAATCCTGGGAAAGGAGAATCCG
TTCAACCCCCAGATTAAACAGGTGTTTGGAGACCAAGGCGGGCACTGA
Protein Properties
Number of Residues 575
Molecular Weight 65104.0
Theoretical pI 8.24
Pfam Domain Function
Signals
  • 1-23
Transmembrane Regions
  • None
Protein Sequence
>Acyloxyacyl hydrolase
MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNS
TVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQ
PLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDICSLPVLAKICQKIKLAMEQSV
PFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKD
GVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQ
LSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVL
DYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPD
GTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQL
SNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLA
DHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH
GenBank ID Protein 62898684
UniProtKB/Swiss-Prot ID P28039
UniProtKB/Swiss-Prot Entry Name AOAH_HUMAN
PDB IDs Not Available
GenBank Gene ID AK223476
GeneCard ID AOAH
GenAtlas ID AOAH
HGNC ID HGNC:548
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205 ]
  3. Hagen FS, Grant FJ, Kuijper JL, Slaughter CA, Moomaw CR, Orth K, O'Hara PJ, Munford RS: Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides. Biochemistry. 1991 Aug 27;30(34):8415-23. [PubMed:1883828 ]