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Identification
HMDB Protein ID HMDBP00573
Secondary Accession Numbers
  • 5845
Name GTP:AMP phosphotransferase, mitochondrial
Synonyms
  1. AK 3
  2. Adenylate kinase 3
  3. Adenylate kinase 3 alpha-like 1
Gene Name AK3
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Not Available
Pathways
  • Beta Ureidopropionase Deficiency
  • Dihydropyrimidinase Deficiency
  • MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
  • Pyrimidine metabolism
  • Pyrimidine metabolism
  • UMP Synthase Deficiency (Orotic Aciduria)
Reactions
NTP + Adenosine monophosphate → NDP + ADP details
Uridine triphosphate + Adenosine monophosphate → Uridine 5'-diphosphate + ADP details
GO Classification
Biological Process
blood coagulation
AMP metabolic process
AMP phosphorylation
GTP metabolic process
ITP metabolic process
UTP metabolic process
Cellular Component
mitochondrial matrix
Function
binding
catalytic activity
nucleotide kinase activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
adenylate kinase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleobase, nucleoside, nucleotide kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Molecular Function
ATP binding
GTP binding
adenylate kinase activity
nucleoside triphosphate adenylate kinase activity
nucleotide kinase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Cellular Location
  1. Mitochondrion matrix
Gene Properties
Chromosome Location 9
Locus 9p24.1
SNPs AK3
Gene Sequence
>684 bp
ATGGGGGCGTCGGGGCGGCTGCTGCGAGCGGTGATCATGGGGGCCCCGGGCTCGGGCAAG
GGCACCGTGTCGTCCCGCATCACTACACACTTCGAGCTGAAGCACCTCTCCCGCGGGGAC
CTGCTCCGGGACAACATGCTGCGGGGCACAGAAATTGGCGTGTTAGCCCAGGCTTTCATT
GACCAAGGGAAACTCATCCCAGATTATGTCACGACTCGGCTGGCCCTTCATGAGCTGAAA
AACCTCACCCAGTATAGCTGGCTGTTGGATGGTTTTCCAAGGACACTTCCACAGGCAGAA
GCCCTAGATAGAGCTTATCAGATCGACACAGTGATTAACCTGAATGTGCCCTTTGAGGTC
ATTAAACAACGCCTTACTGCTCGCTGGATTCATCCCGCCAGTGGCCGAGTCTATAACATT
GAATTCAACCCTCCCAAAACTGTGGGCATTGATGACCTGACTGGGGAGCCTCTCATTCAG
CGTGAGGATGATAAACCAGAGACGGTTATCAAGAGACTAAAGGCTTATGAAGACCAAACA
AAGCCAGTCCTGGAATATTACCAGAAAAAAGGGGTGTTGGAAACATTCTCCGGAACAGAA
ACCAACAAGATTTGGCCCTATGTATATGCTTTCCTACAAACTAAAGTTCCACAAAGAAGC
CAGAAAGCTTCAGTTACTCCATGA
Protein Properties
Number of Residues 227
Molecular Weight 21013.93
Theoretical pI 9.522
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>GTP:AMP phosphotransferase, mitochondrial
MGASARLLRAVIMGAPGSGKGTVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFI
DQGKLIPDDVMTRLALHELKNLTQYSWLLDGFPRTLPQAEALDRAYQIDTVINLNVPFEV
IKQRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQREDDKPETVIKRLKAYEDQT
KPVLEYYQKKGVLETFSGTETNKIWPYVYAFLQTKVPQRSQKASVTP
GenBank ID Protein 6518533
UniProtKB/Swiss-Prot ID Q9UIJ7
UniProtKB/Swiss-Prot Entry Name KAD3_HUMAN
PDB IDs
GenBank Gene ID AB021870
GeneCard ID AK3
GenAtlas ID AK3
HGNC ID HGNC:17376
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
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