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Showing Protein SUMO-conjugating enzyme UBC9 (HMDBP00635)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 metabolites
Identification
HMDB Protein ID HMDBP00635
Secondary Accession Numbers
  • 5907
Name SUMO-conjugating enzyme UBC9
Synonyms
  1. SUMO-protein ligase
  2. Ubiquitin carrier protein 9
  3. Ubiquitin carrier protein I
  4. Ubiquitin-conjugating enzyme E2 I
  5. Ubiquitin-protein ligase I
  6. p18
Gene Name UBE2I
Protein Type Enzyme
Biological Properties
General Function Involved in acid-amino acid ligase activity
Specific Function Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.
Pathways
  • NF-kappa B signaling pathway
  • Nucleocytoplasmic transport
  • protein sumoylation
  • Ubiquitin mediated proteolysis
Reactions
Adenosine triphosphate + SUMO + protein lysine → Adenosine monophosphate + Pyrophosphate + protein N-SUMOyllysine details
GO Classification
Biological Process
cell division
ubiquitin-dependent protein catabolic process
chromosome segregation
positive regulation of intracellular steroid hormone receptor signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
virus-host interaction
negative regulation of transcription from RNA polymerase II promoter
protein sumoylation
regulation of receptor activity
proteasomal ubiquitin-dependent protein catabolic process
mitosis
Cellular Component
cytoplasm
dendrite
fibrillar center
synaptonemal complex
PML body
synapse
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
SUMO ligase activity
Process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location 16
Locus 16p13.3
SNPs UBE2I
Gene Sequence 
>477 bp
ATGTCGGGGATCGCCCTCAGCAGACTCGCCCAGGAGAGGAAAGCATGGAGGAAAGACCAC
CCATTTGGTTTCGTGGCTGTCCCAACAAAAAATCCCGATGGCACGATGAACCTCATGAAC
TGGGAGTGCGCCATTCCAGGAAAGAAAGGGACTCCGTGGGAAGGAGGCTTGTTTAAACTA
CGGATGCTTTTCAAAGATGATTATCCATCTTCGCCACCAAAATGTAAATTCGAACCACCA
TTATTTCACCCGAATGTGTACCCTTCGGGGACAGTGTGCCTGTCCATCTTAGAGGAGGAC
AAGGACTGGAGGCCAGCCATCACAATCAAACAGATCCTATTAGGAATACAGGAACTTCTA
AATGAACCAAATATCCAAGACCCAGCTCAAGCAGAGGCCTACACGATTTACTGCCAAAAC
AGAGTGGAGTACGAGAAAAGGGTCCGAGCACAAGCCAAGAAGTTTGCGCCCTCATAA
Protein Properties
Number of Residues 158
Molecular Weight 18006.665
Theoretical pI 8.659
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>SUMO-conjugating enzyme UBC9
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKL
RMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELL
NEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
GenBank ID Protein 4507785
UniProtKB/Swiss-Prot ID P63279
UniProtKB/Swiss-Prot Entry Name UBC9_HUMAN
PDB IDs
GenBank Gene ID NM_003345.3
GeneCard ID UBE2I
GenAtlas ID UBE2I
HGNC ID HGNC:12485
References
General References
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