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Identification
HMDB Protein ID HMDBP00799
Secondary Accession Numbers
  • 6079
Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Synonyms
  1. 6-phosphofructo-2-kinase
  2. 6PF-2-K/Fru-2,6-P2ase 1
  3. 6PF-2-K/Fru-2,6-P2ase liver isozyme
  4. Fructose-2,6-bisphosphatase
  5. PFK/FBPase 1
Gene Name PFKFB1
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Synthesis and degradation of fructose 2,6-bisphosphate.
Pathways
  • Fructose and mannose metabolism
  • Fructose and mannose metabolism
  • Fructose intolerance, hereditary
  • Fructosuria
  • HIF-1 signaling pathway
Reactions
D-Fructose 2,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate details
Adenosine triphosphate + Fructose 6-phosphate → ADP + D-Fructose 2,6-bisphosphate details
D-Fructose 2,6-bisphosphate + Water → Beta-D-Fructose 6-phosphate + Phosphate details
GO Classification
Biological Process
small molecule metabolic process
fructose metabolic process
organ regeneration
response to glucagon stimulus
glycolysis
response to insulin stimulus
response to starvation
intracellular protein kinase cascade
gluconeogenesis
response to glucocorticoid stimulus
positive regulation of glucokinase activity
energy reserve metabolic process
fructose 2,6-bisphosphate metabolic process
response to cAMP
Cellular Component
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
phosphotransferase activity, alcohol group as acceptor
phosphofructokinase activity
6-phosphofructo-2-kinase activity
Molecular Function
ATP binding
fructose-2,6-bisphosphate 2-phosphatase activity
6-phosphofructo-2-kinase activity
fructose-6-phosphate binding
Process
metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
fructose metabolic process
fructose 2,6-bisphosphate metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location X
Locus Xp11.21
SNPs PFKFB1
Gene Sequence
>1416 bp
ATGTCTCCAGAGATGGGAGAGCTCACCCAAACCAGGTTGCAGAAGATCTGGATTCCACAC
AGCAGCGGCAGCAGCAGGCTGCAACGGAGAAGGGGCTCATCCATACCCCAGTTTACCAAT
TCCCCCACAATGGTGATCATGGTGGGTTTACCAGCTCGAGGCAAGACCTATATCTCCACA
AAGCTCACACGATATCTCAACTGGATAGGAACACCAACTAAAGTGTTTAATTTAGGCCAG
TATCGACGAGAGGCAGTGAGCTACAAGAACTATGAATTCTTTCTTCCAGACAACATGGAA
GCCCTGCAAATCAGGAAGCAGTGCGCCCTGGCAGCCCTGAAGGATGTTCACAACTATCTC
AGCCATGAGGAAGGTCATGTTGCGGTTTTTGATGCCACCAACACTACCAGAGAACGACGG
TCACTGATCCTGCAGTTTGCAAAAGAACATGGTTACAAGGTGTTTTTCATTGAGTCCATT
TGTAATGACCCTGGCATAATTGCAGAAAACATCAGGCAAGTGAAACTTGGCAGCCCTGAT
TATATAGACTGTGACCGGGAAAAGGTTCTGGAAGACTTTCTAAAGAGAATTGAGTGCTAT
GAGGTCAACTACCAACCCTTGGATGAGGAACTGGACAGCCACCTGTCCTACATCAAGATC
TTCGACGTGGGCACACGCTACATGGTGAACCGAGTGCAGGATCACATCCAGAGCCGCACA
GTCTACTACCTCATGAATATCCATGTCACACCTCGCTCCATCTACCTTTGCCGACATGGC
GAGAGTGAACTCAACATCAGAGGCCGCATCGGAGGTGACTCTGGCCTCTCAGTTCGCGGC
AAGCAGTATGCCTATGCCCTGGCCAACTTCATTCAGTCCCAGGGCATCAGCTCCCTGAAG
GTGTGGACCAGTCGCATGAAGAGGACCATCCAGACAGCTGAGGCCCTGGGTGTCCCCTAT
GAGCAGTGGAAGGCCCTGAATGAGATTGATGCGGGTGTCTGTGAGGAGATGACCTATGAA
GAAATCCAGGAACATTACCCTGAAGAATTTGCACTGCGAGACCAAGATAAATATCGCTAC
CGCTATCCCAAGGGAGAGTCCTATGAGGATCTGGTTCAGCGTCTGGAGCCAGTGATAATG
GAGCTAGAACGACAGGAGAATGTACTGGTGATCTGCCACCAGGCTGTCATGCGGTGCCTC
CTGGCCTATTTCCTGGATAAAAGTTCAGATGAGCTTCCATATCTCAAGTGCCCTCTGCAC
ACAGTGCTCAAACTCACTCCTGTGGCTTATGGCTGCAAAGTGGAATCCATCTACCTGAAT
GTGGAGGCCGTGAACACACACCGGGAGAAGCCTGAGAATGTGGACATCACCCGGGAACCT
GAGGAAGCCCTGGATACTGTCCCAGCCCACTACTGA
Protein Properties
Number of Residues 471
Molecular Weight 54680.86
Theoretical pI 6.586
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYIST
KLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYL
SHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPD
YIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRT
VYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLK
VWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRY
RYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLH
TVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
GenBank ID Protein 35503
UniProtKB/Swiss-Prot ID P16118
UniProtKB/Swiss-Prot Entry Name F261_HUMAN
PDB IDs
GenBank Gene ID X52638
GeneCard ID PFKFB1
GenAtlas ID PFKFB1
HGNC ID HGNC:8872
References
General References
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