Showing Protein Glutathione peroxidase 1 (HMDBP00828)

• 6109
• HMDBP04838

1. Cellular glutathione peroxidase
2. GPx-1
3. GSHPx-1

• 5-oxoprolinase deficiency
• 5-Oxoprolinuria
• Acetaminophen Action Pathway
• Acetylsalicylic Acid Action Pathway
• Amyotrophic lateral sclerosis
• Antipyrine Action Pathway
• Antrafenine Action Pathway
• Arachidonic acid metabolism
• Arachidonic Acid Metabolism
• Bromfenac Action Pathway
• Carprofen Action Pathway
• Celecoxib Action Pathway
• Diclofenac Action Pathway
• Diflunisal Action Pathway
• Etodolac Action Pathway
• Etoricoxib Action Pathway
• Fenoprofen Action Pathway
• Flurbiprofen Action Pathway
• Gamma-glutamyl-transpeptidase deficiency
• Gamma-Glutamyltransferase Deficiency
• Glutathione metabolism
• Glutathione metabolism
• Glutathione Synthetase Deficiency
• Huntington disease
• Ibuprofen Action Pathway
• Indomethacin Action Pathway
• Ketoprofen Action Pathway
• Ketorolac Action Pathway
• Leukotriene C4 Synthesis Deficiency
• Lornoxicam Action Pathway
• Lumiracoxib Action Pathway
• Magnesium salicylate Action Pathway
• Mefenamic Acid Action Pathway
• Meloxicam Action Pathway
• Nabumetone Action Pathway
• Naproxen Action Pathway
• Nepafenac Action Pathway
• Oxaprozin Action Pathway
• Phenylbutazone Action Pathway
• Piroxicam Action Pathway
• Rofecoxib Action Pathway
• Salicylate-sodium Action Pathway
• Salicylic Acid Action Pathway
• Salsalate Action Pathway
• Sulindac Action Pathway
• Suprofen Action Pathway
• Tenoxicam Action Pathway
• Tiaprofenic Acid Action Pathway
• Tolmetin Action Pathway
• Trisalicylate-choline Action Pathway
• Valdecoxib Action Pathway

1. Cytoplasm

>606 bp
ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCGGCGCGC
CCGTTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTACTTATC
GAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAACGAGCTG
CAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAGTTTGGG
CATCAGGAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGGCCTGGT
GGTGGGTTCGAGCCCAACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCGGGGGCG
CACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCCACCGCG
CTTATGACCGACCCCAAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTTGCCTGG
AACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGCCGCCGC
TTCCAGACCATTGACATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCCAGCTGT
GCCTAG

• GSHPx (PF00255 )

>Glutathione peroxidase 1
MCAARLAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNEL
QRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGA
HPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRR
FQTIDIEPDIEALLSQGPSCA

• 2F8A

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3. Sukenaga Y, Ishida K, Takeda T, Takagi K: cDNA sequence coding for human glutathione peroxidase. Nucleic Acids Res. 1987 Sep 11;15(17):7178. [PubMed:3658677 ]
4. Ishida K, Morino T, Takagi K, Sukenaga Y: Nucleotide sequence of a human gene for glutathione peroxidase. Nucleic Acids Res. 1987 Dec 10;15(23):10051. [PubMed:3697069 ]
5. Mullenbach GT, Tabrizi A, Irvine BD, Bell GI, Hallewell RA: Sequence of a cDNA coding for human glutathione peroxidase confirms TGA encodes active site selenocysteine. Nucleic Acids Res. 1987 Jul 10;15(13):5484. [PubMed:2955287 ]
6. Chada S, Le Beau MM, Casey L, Newburger PE: Isolation and chromosomal localization of the human glutathione peroxidase gene. Genomics. 1990 Feb;6(2):268-71. [PubMed:2307470 ]
7. Moscow JA, Morrow CS, He R, Mullenbach GT, Cowan KH: Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1). J Biol Chem. 1992 Mar 25;267(9):5949-58. [PubMed:1556108 ]
8. Forsberg L, de Faire U, Morgenstern R: Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1. Hum Mutat. 1999;13(4):294-300. [PubMed:10220143 ]
9. Kote-Jarai Z, Durocher F, Edwards SM, Hamoudi R, Jackson RA, Ardern-Jones A, Murkin A, Dearnaley DP, Kirby R, Houlston R, Easton DF, Eeles R: Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer. Prostate Cancer Prostatic Dis. 2002;5(3):189-92. [PubMed:12496980 ]
10. Hamanishi T, Furuta H, Kato H, Doi A, Tamai M, Shimomura H, Sakagashira S, Nishi M, Sasaki H, Sanke T, Nanjo K: Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients. Diabetes. 2004 Sep;53(9):2455-60. [PubMed:15331559 ]
11. Ichimura Y, Habuchi T, Tsuchiya N, Wang L, Oyama C, Sato K, Nishiyama H, Ogawa O, Kato T: Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. J Urol. 2004 Aug;172(2):728-32. [PubMed:15247771 ]