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Identification
HMDB Protein ID HMDBP00844
Secondary Accession Numbers
  • 6125
Name Queuine tRNA-ribosyltransferase
Synonyms
  1. Guanine insertion enzyme
  2. tRNA-guanine transglycosylase
Gene Name QTRT1
Protein Type Unknown
Biological Properties
General Function Involved in queuine tRNA-ribosyltransferase activity
Specific Function Interacts with QTRTD1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).
Pathways
  • tRNA-queuosine biosynthesis
Reactions
Guanine(34) in tRNA + Queuine → queuosine(34) in tRNA + Guanine details
tRNA guanine + Queuine → tRNA queuine + Guanine details
tRNA guanine + 7-Aminomethyl-7-carbaguanine → tRNA 7-aminomethyl-7-carbaguanine + Guanine details
GO Classification
Biological Process
queuosine biosynthetic process
Cellular Component
mitochondrion
nucleus
ribosome
Function
catalytic activity
transferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
queuine trna-ribosyltransferase activity
Molecular Function
metal ion binding
queuine tRNA-ribosyltransferase activity
Process
rna metabolic process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
trna modification
queuosine biosynthetic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Mitochondrion
Gene Properties
Chromosome Location 19
Locus 19p13.3
SNPs QTRT1
Gene Sequence
>1212 bp
ATGGCGGGAGCAGCTACCCAGGCTTCCCTGGAGTCGGCCCCACGGATCATGCGGCTGGTG
GCCGAATGCAGCCGCTCCAGGGCCCGGGCAGGCGAGCTGTGGCTGCCGCATGGGACAGTG
GCCACTCCTGTGTTCATGCCAGTGGGCACGCAGGCCACCATGAAGGGCATCACGACCGAA
CAGCTGGACGCTCTGGGTTGCCGCATCTGCCTGGGCAATACCTACCATCTGGGTCTAAGG
CCGGGACCCGAGCTGATCCAGAAAGCCAACGGTCTCCACGGCTTCATGAATTGGCCTCAT
AATCTGCTAACGGACAGCGGCGGTTTCCAGATGGTGTCGCTGGTGTCTCTGTCCGAGGTG
ACGGAGGAGGGCGTCCGCTTCCGCTCCCCCTACGACGGCAATGAGACCCTGCTGAGCCCG
GAGAAATCCGTGCAGATCCAGAATGCGCTGGGCTCGGACATCATCATGCAGCTGGACGAC
GTGGTTAGCAGTACTGTGACTGGGCCACGTGTGGAGGAGGCCATGTACAGGTCAATCCGC
TGGCTGGACCGGTGCATTGCAGCCCATCAGCGGCCGGACAAGCAGAACCTCTTCGCCATT
ATCCAGGGTGGGCTGGACGCAGATCTCCGGGCCACCTGCCTTGAAGAGATGACCAAGCGA
GACGTGCCTGGCTTCGCCATCGGGGGCCTGAGCGGGGGTGAGAGCAAGTCGCAGTTCTGG
CGGATGGTGGCGCTGAGCACCTCTCGGCTGCCGAAGGACAAGCCCCGATATCTGATGGGG
GTTGGCTATGCCACTGATCTGGTAGTCTGCGTGGCTCTTGGATGTGACATGTTCGACTGC
GTCTTCCCCACACGGACAGCGCGCTTTGGCTCTGCCCTGGTGCCCACTGGGAACCTGCAG
TTGAGGAAGAAGGTGTTTGAGAAGGACTTCGGCCCCATAGACCCGGAGTGCACCTGCCCC
ACGTGCCAAAAGCACAGCCGCGCCTTCCTGCACGCACTGCTGCACAGTGACAACACGGCC
GCGCTGCACCACCTCACGGTCCACAACATCGCCTACCAGCTGCAGCTCATGAGCGCCGTC
CGCACCAGCATCGTGGAGAAGCGCTTCCCGGACTTCGTGCGGGACTTCATGGGCGCCATG
TACGGGGATCCCACCCTCTGTCCCACCTGGGCCACTGACGCTCTGGCCTCTGTGGGAATC
ACACTTGGCTGA
Protein Properties
Number of Residues 403
Molecular Weight 44047.3
Theoretical pI 7.229
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Queuine tRNA-ribosyltransferase
MAGAATQASLESAPRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTE
QLDALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVSLVSLSEV
TEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVSSTVTGPRVEEAMYRSIR
WLDRCIAAHQRPDKQNLFAIIQGGLDADLRATCLEEMTKRDVPGFAIGGLSGGESKSQFW
RMVALSTSRLPKDKPRYLMGVGYATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQ
LRKKVFEKDFGPIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAV
RTSIVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BXR0
UniProtKB/Swiss-Prot Entry Name TGT_HUMAN
PDB IDs Not Available
GenBank Gene ID AF302783
GeneCard ID QTRT1
GenAtlas ID QTRT1
HGNC ID HGNC:23797
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed:15057824 ]
  3. Deshpande KL, Katze JR: Characterization of cDNA encoding the human tRNA-guanine transglycosylase (TGT) catalytic subunit. Gene. 2001 Mar 7;265(1-2):205-12. [PubMed:11255023 ]