| Identification |
|---|
| HMDB Protein ID
| HMDBP01014 |
| Secondary Accession Numbers
| |
| Name
| Leukotriene-B(4) omega-hydroxylase 2 |
| Synonyms
|
- CYPIVF3
- Cytochrome P450 4F3
- Cytochrome P450-LTB-omega
- Leukotriene-B(4) 20-monooxygenase 2
|
| Gene Name
| CYP4F3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes.
|
| Pathways
|
- Acetaminophen Action Pathway
- Acetylsalicylic Acid Action Pathway
- Antipyrine Action Pathway
- Antrafenine Action Pathway
- Arachidonic acid metabolism
- Arachidonic Acid Metabolism
- Bromfenac Action Pathway
- Carprofen Action Pathway
- Celecoxib Action Pathway
- Diclofenac Action Pathway
- Diflunisal Action Pathway
- Etodolac Action Pathway
- Etoricoxib Action Pathway
- Fenoprofen Action Pathway
- Flurbiprofen Action Pathway
- Ibuprofen Action Pathway
- Indomethacin Action Pathway
- Ketoprofen Action Pathway
- Ketorolac Action Pathway
- leukotriene B4 degradation
- Leukotriene C4 Synthesis Deficiency
- Lornoxicam Action Pathway
- Lumiracoxib Action Pathway
- Magnesium salicylate Action Pathway
- Mefenamic Acid Action Pathway
- Meloxicam Action Pathway
- Nabumetone Action Pathway
- Naproxen Action Pathway
- Nepafenac Action Pathway
- Oxaprozin Action Pathway
- Phenylbutazone Action Pathway
- Piroxicam Action Pathway
- Rofecoxib Action Pathway
- Salicylate-sodium Action Pathway
- Salicylic Acid Action Pathway
- Salsalate Action Pathway
- Sulindac Action Pathway
- Suprofen Action Pathway
- Tenoxicam Action Pathway
- Tiaprofenic Acid Action Pathway
- Tolmetin Action Pathway
- Trisalicylate-choline Action Pathway
- Valdecoxib Action Pathway
|
| Reactions
|
| Leukotriene B4 + NADPH + Oxygen → 20-Hydroxy-leukotriene B4 + NADP + Water |
details
|
| Leukotriene B4 + NADPH + Hydrogen Ion + Oxygen → 20-Hydroxy-leukotriene B4 + NADP + Water |
details
|
| Arachidonic acid + Oxygen + NADPH + Hydrogen Ion → 20-Hydroxyeicosatetraenoic acid + NADP + Water |
details
|
|
| GO Classification
|
| Biological Process |
| xenobiotic metabolic process |
| leukotriene B4 catabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| monooxygenase activity |
| heme binding |
| oxidoreductase activity |
| Molecular Function |
| electron carrier activity |
| monooxygenase activity |
| iron ion binding |
| heme binding |
| leukotriene-B4 20-monooxygenase activity |
| alpha-tocopherol omega-hydroxylase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Single-pass membrane protein
- Microsome membrane
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.2 |
| SNPs
| CYP4F3 |
| Gene Sequence
|
>1563 bp
ATGCCACAGCTGAGCCTGTCCTCGCTGGGCCTTTGGCCAATGGCAGCATCCCCGTGGCTG
CTCCTGCTGCTGGTTGGGGCCTCCTGGCTCCTGGCCCGCATCCTGGCCTGGACCTATACC
TTCTATGACAACTGCTGCCGCCTCCGGTGTTTCCCGCAACCCCCGAAACGGAATTGGTTC
TTGGGTCACCTGGGCCTGATTCACAGCTCGGAGGAAGGTCTCCTATACACACAAAGCCTG
GCATGCACCTTCGGTGATATGTGCTGCTGGTGGGTGGGGCCCTGGCACGCAATCGTCCGC
ATCTTCCACCCCACCTACATCAAGCCTGTGCTCTTTGCTCCAGCTGCCATTGTACCAAAG
GACAAGGTCTTCTACAGCTTCCTGAAGCCCTGGCTGGGGGATGGGCTCCTGCTGAGTGCT
GGTGAAAAGTGGAGCCGCCACCGTCGGATGCTGACGCCTGCCTTCCATTTCAACATCCTG
AAGCCCTATATGAAGATTTTCAATGAGAGTGTGAACATCATGCATGCCAAGTGGCAGCTC
CTGGCCTCAGAGGGTAGTGCCCGTCTGGACATGTTTGAGCACATCAGCCTCATGACCTTG
GACAGTCTGCAGAAATGTGTCTTCAGCTTTGACAGCCATTGCCAGGAGAAGCCCAGTGAA
TATATTGCCGCCATCTTGGAGCTCAGTGCCCTTGTGACAAAAAGACACCAGCAGATCCTC
CTGTACATAGACTTCCTGTATTATCTCACCCCTGATGGGCAGCGTTTCCGCAGGGCCTGC
CGCCTGGTGCACGACTTCACAGATGACGTCATCCAGGAGCGGCGCCGCACCCTCCCTAGC
CAGGGTGTTGATGACTTCCTCCAAGCCAAGGCCAAATCCAAGACTTTGGACTTCATTGAT
GTACTCCTGCTGAGCAAGGATGAAGATGGGAAGAAGTTGTCCGATGAGGACATAAGAGCA
GAAGCTGACACCTTTATGTTTGAGGGCCATGACACCACAGCCAGTGGTCTCTCCTGGGTC
CTGTACCACCTTGCAAAGCACCCGGAATACCAGGAGCGCTGTCGGCAGGAGGTACAAGAG
CTTCTGAAGGACCGTGAGCCTAAAGAGATTGAATGGGACGACCTGGCCCAGCTGCCCTTC
CTGACCATGTGCATTAAGGAGAGCCTGAGGCTGCATCCCCCAGTCCCTGCCGTCTCTCGC
TGCTGCACCCAAGACATTGTGCTCCCAGACGGCCGGGTCATCCCCAAAGGCATTATCTGC
CTCATCAGTGTTTTTGGAACCCATCACAACCCAGCCGTGTGGCCGGACCCTGAGGTCTAT
GACCCCTTTCGCTTTGACCCAAAGAACATCAAGGAGAGGTCACCTCTGGCTTTTATTCCC
TTCTCAGCAGGGCCCAGGAACTGCATCGGGCAGGCGTTCGCGATGGCGGAGATGAAGGTG
GTCCTGGGGCTCACGCTGCTGGCCTTCCGCGTCCTGCCTGACCACACCGAGCCCCGCAGG
AAGCCGGAGCTGGTCCTGCGCGCAGAGGGCGGACTTTGGCTGCGGGTGGAGCCCCTGAGC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 520 |
| Molecular Weight
| 59846.085 |
| Theoretical pI
| 7.633 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Leukotriene-B(4) omega-hydroxylase 2
MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF
LGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPK
DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL
LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC
LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV
VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
|
| External Links |
|---|
| GenBank ID Protein
| 3123723 |
| UniProtKB/Swiss-Prot ID
| Q08477 |
| UniProtKB/Swiss-Prot Entry Name
| CP4F3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB002454 |
| GeneCard ID
| CYP4F3 |
| GenAtlas ID
| CYP4F3 |
| HGNC ID
| HGNC:2646 |
| References |
|---|
| General References
| - Kikuta Y, Kusunose E, Endo K, Yamamoto S, Sogawa K, Fujii-Kuriyama Y, Kusunose M: A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase. J Biol Chem. 1993 May 5;268(13):9376-80. [PubMed:8486631 ]
- Kikuta Y, Kato M, Yamashita Y, Miyauchi Y, Tanaka K, Kamada N, Kusunose M: Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. DNA Cell Biol. 1998 Mar;17(3):221-30. [PubMed:9539102 ]
|
